Výsledky vyhledávání - "Pedro J, Beltran"

Akademický článek

OncoVEXmGM-CSFexpands tumor antigen-specific CD8+ T-cell response in preclinical models

Autor: Jinghui Zhan, Petia Mitchell, Juan Estrada, Jonathan Werner, Jason DeVoss, Pedro J Beltran, Jing Qing, Keegan S Cooke

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)

Background Checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) have demonstrated clinical efficacy in advanced melanoma, but only a sub

Externí odkaz: https://doaj.org/article/36defbad0cc24b22bfdec87dbe9052f1

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Akademický článek

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

Autor: Kai Mao, Gabriela Farias Quipildor, Tahmineh Tabrizian, Ardijana Novaj, Fangxia Guan, Ryan O. Walters, Fabien Delahaye, Gene B. Hubbard, Yuji Ikeno, Keisuke Ejima, Peng Li, David B. Allison, Hossein Salimi-Moosavi, Pedro J. Beltran, Pinchas Cohen, Nir Barzilai, Derek M. Huffman

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the benef

Externí odkaz: https://doaj.org/article/6c2da7569db9463080f4475bda1b2e80

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