Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Pedro Henrique Viana Saavedra"'
Autor:
Mate Kiss, Geert Raes, Maryse Schmoetten, Helena Van Damme, Andy Wullaert, Jiri Keirsse, Mohamed Lamkanfi, Yvon Elkrim, Pauline M. R. Bardet, Junbin Qian, Aleksandar Murgaski, Louis Boon, Diether Lambrechts, Samantha Pretto, Alain Beschin, Geert van Loo, Massimiliano Mazzone, Manuel Ehling, Jo A. Van Ginderachter, Damya Laoui, Sana M. Arnouk, Evangelia Bolli, Ayla Debraekeleer, Amelie Fossoul, Els Lebegge, Jan Brughmans, Lieselotte Vande Walle, Pedro Henrique Viana Saavedra
IL1β is a central mediator of inflammation. Secretion of IL1β typically requires proteolytic maturation by the inflammasome and formation of membrane pores by gasdermin D (GSDMD). Emerging evidence suggests an important role for IL1β in promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecbd8e2b94bd021c47f81139d016a57
https://doi.org/10.1158/2326-6066.cir-20-0431
https://doi.org/10.1158/2326-6066.cir-20-0431
Autor:
Alexandre Gallerand, Arnaud Jacquel, Pedro Henrique Viana Saavedra, Cedric Torre, Paul Chaintreuil, Sandrine Marchetti, Alissa Majoor, Mohamed Lamkanfi, Raymond Ruimy, Céline Loubatier, Amaury Rey, Anne Doye, Laurent Boyer, Benedicte F. Py, Grégory Michel, Johan Courjon, Rodolphe Guinamard, Patrick Munro, Dorota Czerucka, Orane Visvikis, Océane Dufies, Els Verhoeyen
Publikováno v:
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2021, 6 (3), pp.401-412. ⟨10.1038/s41564-020-00832-5⟩
Nature microbiology
Nature Microbiology, 2021, 6 (3), pp.401-412. ⟨10.1038/s41564-020-00832-5⟩
Nature Microbiology, Nature Publishing Group, 2021, 6 (3), pp.401-412. ⟨10.1038/s41564-020-00832-5⟩
Nature microbiology
Nature Microbiology, 2021, 6 (3), pp.401-412. ⟨10.1038/s41564-020-00832-5⟩
Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition receptors. The consequent inflammasome-triggered caspase-1 activation is critical for the host defence against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f03b7b7351ee08b0a26e57e7c5e8244
https://hal.archives-ouvertes.fr/hal-03473187
https://hal.archives-ouvertes.fr/hal-03473187
Cryptococcus neoformans Secretes Small Molecules That Inhibit IL-1β Inflammasome-Dependent Secretion
Autor:
Joshua D. Nosanchuk, Aldo Henrique Tavares, Patrícia Albuquerque, Paulo Henrique de Holanda Veloso Janior, Robin C. May, Carolina Coelho, Arturo Casadevall, Pedro Henrique Viana Saavedra, Raffael Júnio Araújo de Castro, Ernesto S. Nakayasu, Clara Luna Marina, Pedro Henrique Bürgel, Stephan Alberto Machado de Oliveira, Heino M. Heyman, Anamélia Lorenzetti Bocca, Radames J. B. Cordero
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2020 (2020)
Mediators of Inflammation, Vol 2020 (2020)
Cryptococcus neoformans is an encapsulated yeast that causes disease mainly in immunosuppressed hosts. It is considered a facultative intracellular pathogen because of its capacity to survive and replicate inside phagocytes, especially macrophages. T
Autor:
Hanne Van Gorp, Apurva Kanneganti, Hiroto Kambara, Heather Tillman, R. K. Subbarao Malireddi, Lieselotte Vande Walle, Hongbo R. Luo, Mohamed Lamkanfi, Pedro Henrique Viana Saavedra, Hongbo Chi, Peter Vogel, Ramnik J. Xavier
Publikováno v:
The Journal of Experimental Medicine
JOURNAL OF EXPERIMENTAL MEDICINE
JOURNAL OF EXPERIMENTAL MEDICINE
Inflammasomes promote interleukin (IL)-1β secretion and pyroptosis. Kanneganti et al. now show that the pyroptosis effector gasdermin D (GSDMD) is required for systemic IL-1β secretion and autoinflammatory pathology in a mouse model of Familial Med
Autor:
Lieselotte Vande Walle, Sayumi Yamazoe, Libor Kostka, Jan Konvalinka, Steven T. Staben, Victoria Pham, Dieter Demon, Craig Stivala, Irma B. Stowe, Amelie Fossoul, Mohamed Lamkanfi, Filip Van Hauwermeiren, Pedro Henrique Viana Saavedra, Vladimir Subrt, Pavel Šácha, Nobuhiko Kayagaki, Bettina L. Lee, Petr Šimon
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 9, p e3000354 (2019)
PLOS BIOLOGY
PLOS Biology
PLoS Biology, Vol 17, Iss 9, p e3000354 (2019)
PLOS BIOLOGY
PLOS Biology
The nucleotide-binding-domain (NBD)–and leucine-rich repeat (LRR)–containing (NLR) family, pyrin-domain–containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative dis
Autor:
Andre Correa Amaral, Anamélia Lorenzetti Bocca, Pedro Henrique Viana Saavedra, Paulo C. Morais, Maryanne Trafani de Melo, Antonio Claudio Tedesco, Ana Camila Oliveira Souza, Maria Sueli Soares Felipe
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Objectives In this study, polymeric nanoparticles based on chitosan incorporating the antifungal miconazole nitrate were fabricated and testedin vivo using murine vulvovaginal candidiasis. Methods Nanoparticles prepared by the ionotropic gelation met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549732afe77717a363f8b6d28cef5fcb
Publikováno v:
Nature. 546:606-608
Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667 Rot
Autor:
Farzaneh Ghazavi, Linyan Huang, Pedro Henrique Viana Saavedra, Tom Vanden Berghe, Peter Vandenabeele, Mohamed Lamkanfi, Stephanie Kourula, Nozomi Takahashi
Publikováno v:
NATURE COMMUNICATIONS
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature communications
Clostridium difficile is the leading cause of pseudomembranous colitis in hospitalized patients. C. difficile enterotoxins TcdA and TcdB promote this inflammatory condition via a cytotoxic response on intestinal epithelial cells (IECs), but the under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443e028d20e929aeaabf1a5f62fb8e6a
https://hdl.handle.net/1854/LU-8599172
https://hdl.handle.net/1854/LU-8599172
Publikováno v:
Seminars in Immunopathology. 37:313-322
Over recent years, inflammasomes have emerged as key regulators of immune and inflammatory responses. They induce programmed cell death and direct the release of danger signals and the inflammatory cytokines interleukin (IL)-1β and IL-18. The concer
Autor:
Melissa Dullaers, Filip Van Hauwermeiren, Mohamed Lamkanfi, Nathalia Moraes de Vasconcelos, Tino Hochepied, Dieter Demon, Jo Dehoorne, Lieselotte Vande Walle, Delfien Bogaert, Hanne Van Gorp, Fabrizio De Benedetti, Pedro Henrique Viana Saavedra, Elfride De Baere, Giusi Prencipe, Karim Vermaelen, Antonella Insalaco, Filomeen Haerynck, Magdalena Matusiak, Nina Van Opdenbosch
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(50)
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. It is caused by mutations in the inflammasome adaptor Pyrin, but how FMF mutations alter signaling in FMF patients is unknown. Herein, we establish Cl