Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: A case-control study.

Autor: Aldo A M Lima, Domingos B Oliveira, Josiane S Quetz, Alexandre Havt, Mara M G Prata, Ila F N Lima, Alberto M Soares, José Q Filho, Noélia L Lima, Pedro H Q S Medeiros, Ana K S Santos, Herlice N Veras, Rafhaella N D G Gondim, Rafaela C Pankov, Mariana D Bona, Francisco A P Rodrigues, Renato A Moreira, Ana C O M Moreira, Marcelo Bertolini, Luciana R Bertolini, Vicente J F Freitas, Eric R Houpt, Richard L Guerrant

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007154 (2019)

BACKGROUND:Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. METHODOLOG

Externí odkaz: https://doaj.org/article/c355d0d8aff6401f9a90b39c082ece33

Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil.

Autor: Richard L Guerrant, Alvaro M Leite, Relana Pinkerton, Pedro H Q S Medeiros, Paloma A Cavalcante, Mark DeBoer, Margaret Kosek, Christopher Duggan, Andrew Gewirtz, Jonathan C Kagan, Anna E Gauthier, Jonathan Swann, Jordi Mayneris-Perxachs, David T Bolick, Elizabeth A Maier, Marjorie M Guedes, Sean R Moore, William A Petri, Alexandre Havt, Ila F Lima, Mara de Moura Gondim Prata, Josyf C Michaleckyj, Rebecca J Scharf, Craig Sturgeon, Alessio Fasano, Aldo A M Lima

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0158772 (2016)

Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth an

Externí odkaz: https://doaj.org/article/ef20d7da711044f0ac7b01a43a096543

Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study

Autor: Erling Svensen, Gagandeep Kang, Dixner Rengifo Trigoso, M Munirul Islam, Benjamin J.J. McCormick, Ramya Ambikapathi, Sophy Raju, Rita Shrestha, Cláudia B. Abreu, Ram Krishna Chandyo, Maribel Paredes Olotegui, Gaurvika M. L. Nayyar, Archana Mohale, Margaret Kosek, Rebecca Blank, Álvaro M. Leite, Srujan Lam Sharma, Manjeswori Ulak, Richard L. Guerrant, Anup Ramachandran, Robin P. Lazarus, Josiane da Silva Quetz, AM Shamsir Ahmed, Estomih R. Mduma, Binob Shrestha, Anita K. M. Zaidi, Aubrey Bauck, Cesar Banda Chavez, Regisiana Mvungi, Silvia Rengifo Pinedo, Sanjaya K. Shrestha, Jean Gratz, Sudhir Babji, Priyadarshani Karunakaran, Pablo Peñataro Yori, José Q. Filho, Laura E. Murray-Kolb, Rosa Maria Salani Mota, Stephanie A. Richard, Ajila T. George, Sajid Bashir Soofi, Vivek Charu, Rosemary Nshama, Zeba A Rasmussen, M. Steffi Jennifer, Rahul J. Thomas, Ladislaus Blacy Yarrot, Alberto M. Soares, Noélia L. Lima, Laura L. Pendergast, Milena Lima de Moraes, Ila F. N. Lima, A. Catharine Ross, Eric R. Houpt, Ladaporn Bodhidatta, Laura E. Caulfield, Estomih Mduma, Tahmeed Ahmed, Jayaprakash Muliyil, Mery Siguas Salas, Rebecca Dillingham, Shahida Qureshi, Sushil John, Caroline Amour, Francisco Suetônio Bastos Mota, Pedro H. Q. S. Medeiros, Angel Mendez Acosta, Iqbal Hossain, Eliwaza Bayyo, Dinesh Mondal, Imran Ahmed, Buliga Mujaga Swema, H. Costa, Michael Gottlieb, Beena Koshy, Mark A. Miller, Vivian Ota Wang, Jhanelle Graham, Muneera A. Rasheed, Alexandre Havt, Bruna Leal Lima Maciel, Cloupas Mahopo, Anuradha Bose, Prakash S. Shrestha, Jessica C. Seidman, Monica McGrath, Alessandra Di Moura, Ali Turab, Viyada Doan, William Pan, Pascal O. Bessong, Didar Alam, Rakhi Ramadas, Tor A. Strand, Reinaldo B. Oriá, Stephanie Psaki, Karthikeyan Ramanujam, John M. Pascal, Rosa Burga, Amidou Samie, William A. Petri, Dinesh Hariraju, Dennis Lang, Christel Hoest, Robert E. Black, Karen H. Tountas, Mohan Venkata Raghava, Angel Orbe Vasquez, Zulfiqar A Bhutta, Emanuel Nyathi, Julian Torres Flores, Rashidul Haque, Leah J. Barrett, J. Daniel Carreon, Carl J. Mason, Zulfiqar A. Bhutta, Stacey Knobler, Rebecca J. Scharf, Suzanne Simons, Kerry Schulze, Crystal L. Patil, Aldo A. M. Lima, Reeba Roshan, Angelina Maphula, Maribel Paredes Olortegui, James A Platts-Mills, Fahmida Tofail, Shiny Kaki, Asad Ali, Gwenyth O. Lee, Sanjaya K. Shrestra, Mustafa Mahfuz, Shanmuga Sundaram, William Checkley, Barbara A. Schaefer

Publikováno v: The American Journal of Clinical Nutrition

Background Environmental enteric dysfunction (EED) is thought to increase the risk of micronutrient deficiencies, but few studies adjust for dietary intakes and systemic inflammation. Objective We tested whether EED is associated with micronutrient d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0938431c2ba058b258d7abe8b5c0e903
https://doi.org/10.1093/ajcn/nqz151

Enteropathogenic Escherichia coli Infection Induces Diarrhea, Intestinal Damage, Metabolic Alterations, and Increased Intestinal Permeability in a Murine Model

Autor: Pedro H. Q. S. Medeiros, Deiziane Viana da Silva Costa, Solanka E. Ledwaba, Natasha Potgieter, David T. Bolick, Jonathan R. Swann, Richard L. Guerrant, Natasa Giallourou, Afsatou Ndama Traore, James P. Nataro

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC

Enteropathogenic E. coli (EPEC) are recognized as one of the leading bacterial causes of infantile diarrhea worldwide. Weaned C57BL/6 mice pretreated with antibiotics were challenged orally with wild-type EPEC or escN mutant (lacking type 3 secretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5996bafbeff262f4c84839317b8c9b9f
http://europepmc.org/articles/PMC7773950

A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice

Autor: Pedro H. Q. S. Medeiros, David T. Bolick, Deiziane Viana da Silva Costa, Richard L. Guerrant, Reinaldo B. Oriá, Solanka E. Ledwaba, Glynis L. Kolling, Aldo Ângelo Moreira Lima, Eileen M. Barry

Publikováno v: NPJ Vaccines
npj Vaccines, Vol 5, Iss 1, Pp 1-5 (2020)

Vaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18b7c169512b896f3c891771b90d8df
https://doi.org/10.1038/s41541-020-0180-y