Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Pedro H H, Hermkens"'
Autor:
Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M. J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito
Externí odkaz:
https://doaj.org/article/5a569da9aa694e86aa5e04aa0c21ba75
Autor:
Patrick A. M. Jansen, Taco W. A. Kooij, Martijn W. Vos, Manuel Llinás, Floris P. J. T. Rutjes, Sergio Wittlin, Gabrielle A. Josling, Iñigo Angulo-Barturen, Stacy A. Reeves, Julie M. J. Verhoef, Karin M. J. Koolen, Erik L. Allman, Karen Miller, Helmi Pett, Suzanne Jackowski, Judith M. Bolscher, Robert W. Sauerwein, L. E. De Vries, María Belén Jiménez-Díaz, Richard H. Blaauw, Peter N. M. Botman, Graham P. Trevitt, Christien A. Beuckens-Schortinghuis, Brice Campo, Christian Scheurer, Sibylle Sax, Koen J. Dechering, Pedro H. H. Hermkens, Roger Bonnert, Christoph Fischli, Joost Schalkwijk
Publikováno v:
Science Translational Medicine. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6549a95b6758c0507a3f1f8b74eaf188
https://doi.org/10.1126/scitranslmed.abg8900
https://doi.org/10.1126/scitranslmed.abg8900
Autor:
Julie M. J. Verhoef, Rosemary Rochford, Philip J. Rosenthal, Graham P. Trevitt, Patrick K Tumwebaze, Barcelo C, Manuel Llinás, Jacquin C. Niles, Koen J. Dechering, Henderson R, Roger Bonnert, Dhelio Batista Pereira, Anna Caroline Campos Aguiar, Huijs T, Judith M. Bolscher, David A. Fidock, Tomas Yeo, Robert W. Sauerwein, Pasaje Cfa, Jake Baum, Patrick A. M. Jansen, Brice Campo, Roland A. Cooper, Taco W. A. Kooij, de Vries Le, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, Francisco J. Gamo, Josefine Striepen, Pedro H. H. Hermkens, Sergio Wittlin, Rafael Victorio Carvalho Guido, Kelly Rubiano, Justin Munro, Fernandez Bc, Laura M. Sanz, Karin M. J. Koolen, J. Schalkwijk, Alisje Churchyard
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (ACS) inhibitor to enter preclinical development. Our studies d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defffb247aaafa1d1e8ba557aa91a1d8
https://doi.org/10.1101/2021.05.12.443866
https://doi.org/10.1101/2021.05.12.443866
Autor:
Patrick A. M. Jansen, Taco W. A. Kooij, Helmi Pett, Judith M. Bolscher, Suzanne Jackowski, Laura E. de Vries, María Belén Jiménez-Díaz, Brice Campo, Martijn W. Vos, Karin M. J. Koolen, Roger Bonnert, Stacy A. Reeves, Christoph Fischli, Christien A. Beuckens-Schortinghuis, Peter N. M. Botman, Koen J. Dechering, Manuel Llinás, Gabrielle A. Josling, Robert W. Sauerwein, Joost Schalkwijk, Julie M. J. Verhoef, Sergio Wittlin, Karen Miller, Pedro H. H. Hermkens, Graham P. Trevitt, Iñigo Angulo-Barturen, Erik L. Allman, Floris P. J. T. Rutjes, Richard H. Blaauw, Christian Scheurer, Sibylle Sax
Publikováno v:
Science Translational Medicine, 11(510)
Science Translational Medicine, 11, 510, pp. 1-16
Science Translational Medicine, 11, 1-16
Science Translational Medicine 11 (2019) 510
Science Translational Medicine, 11, 510, pp. 1-16
Science Translational Medicine, 11, 1-16
Science Translational Medicine 11 (2019) 510
Malaria eradication is critically dependent on new therapeutics that target resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage Plasmodium falciparum p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef5f25c8bda84ba537ac40b18f93959
https://research.wur.nl/en/publications/antimalarial-pantothenamide-metabolites-target-acetyl-coenzyme-a-
https://research.wur.nl/en/publications/antimalarial-pantothenamide-metabolites-target-acetyl-coenzyme-a-
Autor:
Robert W. Sauerwein, Christoph Fischli, Suzanne Jackowski, Koen J. Dechering, Floris P. J. T. Rutjes, Martijn W. Vos, Christian Scheurer, Helmi Pett, Stacy A. Reeves, Sibylle Sax, Laura E. de Vries, Pedro H. H. Hermkens, Gabrielle A. Josling, Richard H. Blaauw, Sergio Wittlin, Erik L. Allman, Karin M. J. Koolen, Roger Bonnert, Christien A. Beuckens-Schortinghuis, Peter N. M. Botman, Joost Schalkwijk, Brice Campo, Karen Miller, Judith M. Bolscher, Patrick A. M. Jansen, Taco W. A. Kooij, Manuel Llinás, Graham P. Trevitt
Malaria eradication is critically dependent on novel drugs that target resistantPlasmodiumparasites and block transmission of the disease. Here we report the discovery of potent pantothenamide bioisosteres that are active against blood-stageP. falcip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a7559646b6be9035b4dd72ab909023
https://doi.org/10.1101/256669
https://doi.org/10.1101/256669
Autor:
Joost, Schalkwijk, Erik L, Allman, Patrick A M, Jansen, Laura E, de Vries, Julie M J, Verhoef, Suzanne, Jackowski, Peter N M, Botman, Christien A, Beuckens-Schortinghuis, Karin M J, Koolen, Judith M, Bolscher, Martijn W, Vos, Karen, Miller, Stacy A, Reeves, Helmi, Pett, Graham, Trevitt, Sergio, Wittlin, Christian, Scheurer, Sibylle, Sax, Christoph, Fischli, Iñigo, Angulo-Barturen, Mariá Belén, Jiménez-Diaz, Gabrielle, Josling, Taco W A, Kooij, Roger, Bonnert, Brice, Campo, Richard H, Blaauw, Floris P J T, Rutjes, Robert W, Sauerwein, Manuel, Llinás, Pedro H H, Hermkens, Koen J, Dechering
Publikováno v:
Science translational medicine. 11(510)
Malaria eradication is critically dependent on new therapeutics that target resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::841dc2b1d75efe5c50f2f7949ba194d8
https://pubmed.ncbi.nlm.nih.gov/33568524
https://pubmed.ncbi.nlm.nih.gov/33568524
Autor:
Thijs de Boer, Chris L.E. Broekkamp, Jan W. van Nispen, Jane M. L. van der Werf‐Pieters, Pedro H. H. Hermkens, Harry C. J. Ottenheijm
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:95-106
The design cycle of peptidomimetics having CCK-A agonistic activity is discussed. The phases of this strategic approach are discussed briefly and results obtained either in our laboratories or by other groups are elaborated in this framework. Most of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b165738c495cb3b0a8ae536671c8538
https://doi.org/10.1002/recl.19931120205
https://doi.org/10.1002/recl.19931120205
Autor:
Jan H. van Maarseveen, Martin Tulp, Hans W. Scheeren, Pedro H. H. Hermkens, Chris G. Kruse, Gerard D. H. Dijkstra
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:131-136
The synthesis and the affinities for serotonin and tryptamine receptors of a series of N-oxy derivatives of tryptamine (6–8, 13–14) are reported. It was found that N-hydroxytryptamine (6) is a relatively selective ligand for the 5-HT1C receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5e01109c274ccd964b866f217b58cf
https://doi.org/10.1002/recl.19931120210
https://doi.org/10.1002/recl.19931120210
Autor:
Hans Hamersma, Johannes Bernardus Maria Rewinkel, Paul Peter Marie Antonius Dols, Hans Lucas, Cor W. Kuil, Pedro H. H. Hermkens, Lourdes Ollero, Folmer Brigitte Johanna Bernita
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1461-1467
We have developed a new class of progesterone receptor agonists having a tetracyclic dibenzo-oxazepine structure 1. In this paper, the synthesis and structure-activity relationships of this new class are described. This work led to the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5973f6006832490d35f0f6a886cb529e
https://doi.org/10.1016/j.bmcl.2007.12.065
https://doi.org/10.1016/j.bmcl.2007.12.065
Autor:
Kimberly R. de Cuba, Sandrine Calvet-Vitale, Jan A. J. Geenevasen, Jasper Springer, Henk Hiemstra, Pedro H. H. Hermkens, Jan H. van Maarseveen
Publikováno v:
European Journal of Organic Chemistry, 2592-2600. Wiley-VCH Verlag
ISSUE=15;STARTPAGE=2592;ENDPAGE=2600;ISSN=1434-193X;TITLE=European Journal of Organic Chemistry
ISSUE=15;STARTPAGE=2592;ENDPAGE=2600;ISSN=1434-193X;TITLE=European Journal of Organic Chemistry
A backbone amide linker strategy was chosen for the solid-phase synthesis of triazole-containing Cyclic tetra- and pentapeptides. An alkyne-substituted linker derived from 4-hydroxy-2-methoxybenzaldehyde was elongated by using standard "Fmoc-based" s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1726c42044a6092236ce404429d55910
https://hdl.handle.net/11245/1.294294
https://hdl.handle.net/11245/1.294294