Výsledky vyhledávání - "Pedro González-Naranjo"

Akademický článek

Multitarget drugs as potential therapeutic agents for alzheimer’s disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors

Autor: Pedro González-Naranjo, Concepción Pérez, Marina González-Sánchez, Adrián Gironda-Martínez, Eugenia Ulzurrun, Fernando Bartolomé, Marcos Rubio-Fernández, Angeles Martin-Requero, Nuria E. Campillo, Juan A. Páez

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2348-2356 (2022)

Multitarget drugs are a promising therapeutic approach against Alzheimer’s disease. In this work, a new family of 5-substituted indazole derivatives with a multitarget profile including cholinesterase and BACE1 inhibition is described. Thus, the sy

Externí odkaz: https://doaj.org/article/4413ef31a44a48d79464776ae07d0209

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Running Title: multitarget cannabinoid agonists for AD treatment

Autor: Concepción Pérez, María L. de Ceballos, Pedro González-Naranjo, Fernando Bartolomé, Nuria E. Campillo, Emilio Nuñez-Borque, Alejandro Reinares-Sebastián, Juan A. Páez, Carolina Alquezar, Ángeles Martín-Requero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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43 p.-8 fig.-2 tab.
Alzheimer's disease (AD), the leading cause of dementia in the elderly, is a neurodegenerative disorder marked by progressive impairment of cognitive ability. Patients with AD display neuropathological lesions including senil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7d4a52d3959aa15bf4e238cab3d334
https://doi.org/10.1007/s12035-019-01813-4

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Multitarget Drugs As Potential Therapeutic Agents for Alzheimer's Disease. New Family of 5-Substituted Indazole Derivatives as Cholinergic and Bace1 Inhibitors

Autor: Juan Antonio Páez, Pedro González-Naranjo, Concepción Pérez, Marina González-Sánchez, Adrián Gironda-Martínez, Eugenia Ulzurrun, Fernando Bartolomé, Marcos Rubio-Fernández, Angeles Martin-Requero, Nuria E. Campillo

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e955c3ae28343c89ab25a6bbf64c86f
https://doi.org/10.2139/ssrn.4052313

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Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties

Autor: Javier Varela, Nuria E. Campillo, Alicia Merlino, Alicia Gómez-Barrio, José Antonio Escario, Jorge Paniagua-Solis, Mercedes González, María Laura Lavaggi, Gloria Yaluf, Hugo Cerecetto, Pedro González-Naranjo, Cristina Fonseca-Berzal, Angela Guerra, Juan A. Páez

Publikováno v: European Journal of Medicinal Chemistry. 136:223-234

A new family of imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxide with antiproliferative Trypanosoma cruzi properties was identified from a neural network model published by our group. The synthesis and evaluation of this new class of trypanocidal agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7ff9ea8547142a16a56088a7d8071f
https://doi.org/10.1016/j.ejmech.2017.04.075

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Indazolylketones as new multitarget cannabinoid drugs

Autor: Juan A. Páez, M. I. Martín-Fontelles, Concepción Pérez, Carlos Roca, María L. de Ceballos, Rocío Girón, Ángeles Martín-Requero, Gabriela Vaca, Nuria E. Campillo, Pedro González-Naranjo, Natalia Pérez-Macias, Eva Sánchez-Robles

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Multitarget cannabinoids could be a promising therapeutic strategic to fight against Alzheimer's disease. In this sense, our group has developed a new family of indazolylketones with multitarget profile including cannabinoids, cholinesterase and BACE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f318ea73a7994ba4ffec503aa6268317
http://hdl.handle.net/10261/177357

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Cannabinoid derivatives exert a potent anti-myeloma activity bothin vitroandin vivo

Autor: Iván V. Rosado, José Antonio Pérez-Simón, Teresa Caballero-Velázquez, Pedro González-Naranjo, M. Victoria Barbado, Luis Ignacio Sánchez-Abarca, Mayte Medrano, Jesús Martín-Sánchez, Estefania Garcia-Guerrero, Isabel Álvarez-Laderas, Juan A. Páez, Nuria E. Campillo, José I. Piruat

Publikováno v: International Journal of Cancer. 140:674-685

Although hematopoietic and immune system show high levels of the cannabinoid receptor CB2, the potential effect of cannabinoids on hematologic malignancies has been poorly determined. Here we have investigated their anti-tumor effect in multiple myel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a6ce96d264a8e795b83cc4bcc813eb3
https://doi.org/10.1002/ijc.30483

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Targeting CB2 receptor for AD treatment

Autor: Carolina Alquézar, Patricia Del Cerro, Eva Carro, Concepción Pérez, Pedro González-Naranjo, Nuria E. Campillo, Juan A. Páez, Fernando Bartolome, Ángeles Martín-Requero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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43 p.-6 fig.-3 tab. BACKGROUND:Alzheimer's disease is a multifactorial disorder for which there is no disease-modifying treatment yet. CB2 receptors have emerged as a promising therapeutic target for Alzheimer's disease because they are expressed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9073b9a1a0056cef2a6aadbf935e7883
https://pubmed.ncbi.nlm.nih.gov/29736745

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Artificial neural networks based on CODES descriptors in pharmacology: Identification of novel trypanocidal drugs against chagas disease

Autor: Hugo Cerecetto, Nuria E. Campillo, Juan A. Páez, Pedro González-Naranjo, Angela Guerra, Mercedes González

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Scopus-Elsevier

A supervised artificial neural network model has been developed for the accurate prediction of the anti-T. cruzi activity of heterogeneous series of compounds. A representative set of 72 compounds of wide structural diversity was chosen in this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c964b023b8ee502d59453387582490f2
http://hdl.handle.net/10261/95347

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