Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Pedro Geraldo Pascutti"'
Autor:
Lilian Hernández-Alvarez, Antonio B Oliveira Jr, Jorge Enrique Hernández-González, Jorge Chahine, Pedro Geraldo Pascutti, Alexandre Suman de Araujo, Fátima Pereira de Souza
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2027-2044 (2021)
During their life cycle, Leishmania parasites display a fine-tuned regulation of the mRNA translation through the differential expression of isoforms of eukaryotic translation initiation factor 4E (LeishIF4Es). The interaction between allosteric modu
Externí odkaz:
https://doaj.org/article/6ead92ed6d4f49e786c537950ff4a455
Autor:
Lilian Hernández Alvarez, Diego Enry Barreto Gomes, Jorge Enrique Hernández González, Pedro Geraldo Pascutti
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211227 (2019)
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of them are highly toxic and gen
Externí odkaz:
https://doaj.org/article/b249e55470ec4b2bb6860120a89b8e61
Autor:
Priscila Da Silva Figueiredo Celestino Gomes, Isaure Chauvot De Beauchêne, Nicolas Panel, Sophie Lopez, Paulo De Sepulveda, Pedro Geraldo Pascutti, Eric Solary, Luba Tchertanov
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0160165 (2016)
The receptors tyrosine kinases (RTKs) for the colony stimulating factor-1, CSF-1R, and for the stem cell factor, SCFR or KIT, are important mediators of signal transduction. The abnormal function of these receptors, promoted by gain-of-function mutat
Externí odkaz:
https://doaj.org/article/517111bac7be4166aa6cb344e767cf7c
Autor:
Lilian Hernández Alvarez, Dany Naranjo Feliciano, Jorge Enrique Hernández González, R O Soares, Diego Enry Barreto Gomes, Pedro Geraldo Pascutti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003759 (2015)
BACKGROUND:Fasciola hepatica is the causative agent of fascioliasis, a disease affecting grazing animals, causing economic losses in global agriculture and currently being an important human zoonosis. Overuse of chemotherapeutics against fascioliasis
Externí odkaz:
https://doaj.org/article/a3fafc32fcbc40b29fbdb1dc4795c627
Autor:
Priscila Da Silva Figueiredo Celestino Gomes, Nicolas Panel, Elodie Laine, Pedro Geraldo Pascutti, Eric Solary, Luba Tchertanov
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97519 (2014)
The colony stimulating factor-1 receptor (CSF-1R) and the stem cell factor receptor KIT, type III receptor tyrosine kinases (RTKs), are important mediators of signal transduction. The normal functions of these receptors can be compromised by gain-of-
Externí odkaz:
https://doaj.org/article/01991d64ae18428db688a5a42c8f11bd
Autor:
Ana Carolina Rennó Sodero, Bárbara Abrahim-Vieira, Pedro Henrique Monteiro Torres, Pedro Geraldo Pascutti, Célia RS Garcia, Vitor Francisco Ferreira, David Rodrigues da Rocha, Sabrina Baptista Ferreira, Floriano Paes Silva Jr
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 112, Iss 4, Pp 299-308
BACKGROUND Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding.
Externí odkaz:
https://doaj.org/article/e7159ab99f5d409784e6a5ae50342bf3
Autor:
Pedro Geraldo Pascutti
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Um programa computacional foi desenvolvido para otimização de geometria e simulação de dinâmica molecular baseado em um campo de forças clássicas parametrizado. O solvente foi considerado como um contínuo eletrostático e a interface entre o
Autor:
Pedro Geraldo Pascutti
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
Foi realizado um estudo por espectroscopia de ressonancia paramagnetica eletronica de solucoes de complexos formados por melanina sintetica, obtida por auto-oxidacao de l-dopa (dihidroxi-l-fenilalanina), e albumina de soro bovino (bsa). Investigaram-
Autor:
Viviane Corrêa Santos, Paulo Gaio Leite, Lucianna Helene Santos, Pedro Geraldo Pascutti, Peter Kolb, Fabiana Simão Machado, Rafaela Salgado Ferreira
Publikováno v:
European Journal of Medicinal Chemistry. :115498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::163032d1f246bfc9979d7ba9088a466b
https://doi.org/10.1016/j.ejmech.2023.115498
https://doi.org/10.1016/j.ejmech.2023.115498
Neste trabalho, simulações de dinâmica molecular foram realizadas com as proteínas mutantes L81N, I88N, L81NI88N e L50S, a fim de entender o efeito dessas mutações na estrutura e estabilidade dessas proteínas. Os dímeros formados por proteín
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5d05fb14eef106932c200648898769
https://doi.org/10.53268/bkf22050102
https://doi.org/10.53268/bkf22050102
