Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Pedro Geraldo, Pascutti"'
Autor:
Lilian Hernández-Alvarez, Antonio B Oliveira Jr, Jorge Enrique Hernández-González, Jorge Chahine, Pedro Geraldo Pascutti, Alexandre Suman de Araujo, Fátima Pereira de Souza
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2027-2044 (2021)
During their life cycle, Leishmania parasites display a fine-tuned regulation of the mRNA translation through the differential expression of isoforms of eukaryotic translation initiation factor 4E (LeishIF4Es). The interaction between allosteric modu
Externí odkaz:
https://doaj.org/article/6ead92ed6d4f49e786c537950ff4a455
Autor:
Lilian Hernández Alvarez, Diego Enry Barreto Gomes, Jorge Enrique Hernández González, Pedro Geraldo Pascutti
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211227 (2019)
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of them are highly toxic and gen
Externí odkaz:
https://doaj.org/article/b249e55470ec4b2bb6860120a89b8e61
Autor:
Viviane Corrêa Santos, Paulo Gaio Leite, Lucianna Helene Santos, Pedro Geraldo Pascutti, Peter Kolb, Fabiana Simão Machado, Rafaela Salgado Ferreira
Publikováno v:
European Journal of Medicinal Chemistry. :115498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::163032d1f246bfc9979d7ba9088a466b
https://doi.org/10.1016/j.ejmech.2023.115498
https://doi.org/10.1016/j.ejmech.2023.115498
Neste trabalho, simulações de dinâmica molecular foram realizadas com as proteínas mutantes L81N, I88N, L81NI88N e L50S, a fim de entender o efeito dessas mutações na estrutura e estabilidade dessas proteínas. Os dímeros formados por proteín
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5d05fb14eef106932c200648898769
https://doi.org/10.53268/bkf22050102
https://doi.org/10.53268/bkf22050102
Autor:
Carolina Gismene, Jorge Enrique Hernández González, Angela Rocio Niño Santisteban, Andrey Fabricio Ziem Nascimento, Lucas dos Santos Cunha, Fábio Rogério de Moraes, Cristiano Luis Pinto de Oliveira, Caio C. Oliveira, Paola Jocelan Scarin Provazzi, Pedro Geraldo Pascutti, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9857
Universidade de São Paulo (USP)
instacron:USP
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9857
Staphylococcal exfoliative toxins (ETs) are glutamyl endopeptidases that specifically cleave the Glu381-Gly382 bond in the ectodomains of desmoglein 1 (Dsg1) via complex action mechanisms. To date, four ETs have been identified in different Staphyloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a4966ca62e409830dbe79267fe14e1
Autor:
Priscila Da Silva Figueiredo Celestino Gomes, Isaure Chauvot De Beauchêne, Nicolas Panel, Sophie Lopez, Paulo De Sepulveda, Pedro Geraldo Pascutti, Eric Solary, Luba Tchertanov
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0160165 (2016)
The receptors tyrosine kinases (RTKs) for the colony stimulating factor-1, CSF-1R, and for the stem cell factor, SCFR or KIT, are important mediators of signal transduction. The abnormal function of these receptors, promoted by gain-of-function mutat
Externí odkaz:
https://doaj.org/article/517111bac7be4166aa6cb344e767cf7c
Autor:
Lilian Hernández Alvarez, Dany Naranjo Feliciano, Jorge Enrique Hernández González, R O Soares, Diego Enry Barreto Gomes, Pedro Geraldo Pascutti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003759 (2015)
BACKGROUND:Fasciola hepatica is the causative agent of fascioliasis, a disease affecting grazing animals, causing economic losses in global agriculture and currently being an important human zoonosis. Overuse of chemotherapeutics against fascioliasis
Externí odkaz:
https://doaj.org/article/a3fafc32fcbc40b29fbdb1dc4795c627
Autor:
Vitor B. P. Leite, Pedro Geraldo Pascutti, Lilian Hernández Alvarez, Jorge Enrique Hernández González
Publikováno v:
The Journal of Physical Chemistry B. 123:7327-7342
Falcipain-2 (FP-2) is a Plasmodium falciparum cysteine protease that has been extensively targeted to identify novel antimalarials. Remarkably, previous reports have shown that FP-2 can be allosterically modulated and, for a particular noncompetitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f9946df0a67d64a3e6fb2ea00b8705
https://doi.org/10.1021/acs.jpcb.9b05021
https://doi.org/10.1021/acs.jpcb.9b05021
Autor:
Jorge Enrique, Hernández González, Emir, Salas-Sarduy, Lilian, Hernández Alvarez, Diego Enry, Barreto Gomes, Pedro Geraldo, Pascutti, Chris, Oostenbrink, Vitor B P, Leite
Publikováno v:
Journal of computer-aided molecular design. 35(10)
Falcipain-2 (FP-2) is a Plasmodium falciparum hemoglobinase widely targeted in the search for antimalarials. FP-2 can be allosterically modulated by various noncompetitive inhibitors that have been serendipitously identified. Moreover, the crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37126fde44d581c4dc16eb31a9924402
https://pubmed.ncbi.nlm.nih.gov/34617191
https://pubmed.ncbi.nlm.nih.gov/34617191
Autor:
Priscila Da Silva Figueiredo Celestino Gomes, Nicolas Panel, Elodie Laine, Pedro Geraldo Pascutti, Eric Solary, Luba Tchertanov
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97519 (2014)
The colony stimulating factor-1 receptor (CSF-1R) and the stem cell factor receptor KIT, type III receptor tyrosine kinases (RTKs), are important mediators of signal transduction. The normal functions of these receptors can be compromised by gain-of-
Externí odkaz:
https://doaj.org/article/01991d64ae18428db688a5a42c8f11bd