Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Pedro Garção"'
Autor:
Clement Soleilhavoup, Marco Travaglio, Kieran Patrick, Pedro Garção, Elangovan Boobalan, Youri Adolfs, Ruth V. Spriggs, Emma Moles-Garcia, Dalbir Dhiraj, Tony Oosterveen, Sarah L. Ferri, Ted Abel, Edward S. Brodkin, R. Jeroen Pasterkamp, Brian P. Brooks, Lia Panman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The mechanisms regulating midbrain dopaminergic innervation during development are unclear. Here, the authors showed that Nolz1 is required for axonal guidance of dopaminergic neurons during embryonic development of the mouse brain.
Externí odkaz:
https://doaj.org/article/a1e6f0aa3aeb4df3a70d891a709de121
Autor:
Daniel Rial, Adalberto A Castro, Nuno Machado, Pedro Garção, Francisco Q Gonçalves, Henrique B Silva, Angelo R Tomé, Attila Köfalvi, Olga Corti, Rita Raisman-Vozari, Rodrigo A Cunha, Rui D Prediger
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114216 (2014)
There is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits
Externí odkaz:
https://doaj.org/article/10c793ab9b5c4cbf87c977c86e3d079a
Autor:
Clement Soleilhavoup, Kieran Patrick, Ulrika Marklund, Emma Moles-Garcia, Lucie Combes-Soia, Peter Hohenstein, Rosa Peltrini, Marco Travaglio, Shahida Sheraz, Lia Panman, Pedro Garção, Tony Oosterveen, Valérie Labas
Publikováno v:
Stem Cell Reports
Stem Cell Reports, 16(11), 2718-2735. CELL PRESS
Stem Cell Reports, 16(11), 2718-2735. CELL PRESS
Summary In Parkinson’s disease (PD), substantia nigra (SN) dopaminergic (DA) neurons degenerate, while related ventral tegmental area (VTA) DA neurons remain relatively unaffected. Here, we present a methodology that directs the differentiation of
Autor:
Ruth V. Spriggs, R. Jeroen Pasterkamp, Lia Panman, Clement Soleilhavoup, Brian P. Brooks, Kieran Patrick, Emma Moles-Garcia, Marco Travaglio, Tony Oosterveen, Pedro Garção, Youri Adolfs, Sarah L. Ferri, Edward S. Brodkin, Ted Abel, Elangovan Boobalan, Dalbir Dhiraj
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Funder: Vetenskapsrådet (Swedish Research Council); doi: https://doi.org/10.13039/501100004359
Midbrain dopaminergic (DA) axons make long longitudinal projections towards the striatum. Despite the importance of DA striatal innervation, processe
Midbrain dopaminergic (DA) axons make long longitudinal projections towards the striatum. Despite the importance of DA striatal innervation, processe
Autor:
Sara Cimini, Tiziana Borsello, Daniel C. Maddison, Mariaelena Repici, Pedro Garção, Kathryn S. Lilley, Kornelis Straatman, Lia Panman, Flaviano Giorgini, Éva M. Szegö, Tiago F. Outeiro, Bhavini Patel, Mahdieh Hassanjani
Publikováno v:
Molecular Neurobiology
Mutations in the gene encoding DJ-1 are associated with autosomal recessive forms of Parkinson’s disease (PD). DJ-1 plays a role in protection from oxidative stress, but how it functions as an “upstream” oxidative stress sensor and whether this
Autor:
Jean-Marie Vaugeois, Nuno J. Machado, Malika El Yacoubi, Inês M. Araújo, Ângelo R. Tomé, Pedro Garção, Ana Isabel Santos, Henrique B. Silva, Ana Paula Ardais, Manuella P. Kaster, Lisiane O. Porciúncula, Rodrigo A. Cunha, Daniela Pochmann, Attila Köfalvi, Ana Patrícia Simões, Paula Agostinho, Catarina Gomes, Diana I Rodrigues
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Caffeine prophylactically prevents mood and memory impairments through adenosine A(2A) receptor (A(2A)R) antagonism. A(2A)R antagonists also therapeutically revert mood and memory impairments, but it is not known if caffeine is also therapeutically o
Autor:
Attila Köfalvi, Zoltán S. Zádori, Bárbara S. Pinheiro, Catherine Ledent, Pedro Garção, Samira G. Ferreira, Carla S. da Silva-Santos, László Köles
Publikováno v:
Brain Research Bulletin. 97:126-135
Neocortical and striatal TRPV1 (vanilloid or capsaicin) receptors (TRPV1Rs) are excitatory ligand-gated ion channels, and are implicated in psychiatric disorders. However, the purported presynaptic neuromodulator role of TRPV1Rs in glutamatergic, ser
Autor:
Pedro Garção, Rui Daniel Prediger, Rodrigo A. Cunha, Adalberto A. Castro, Eszter Szabó, Paula Agostinho, Attila Köfalvi, Ângelo R. Tomé, S Wopereis
Publikováno v:
British Journal of Pharmacology. 169:1600-1611
Background and Purpose Pre-synaptic nicotinic ACh receptors (nAChRs) and adenosine A2A receptors (A2ARs) are involved in the control of dopamine release and are putative therapeutic targets in Parkinson's disease and addiction. Since A2ARs have been
Autor:
Attila Köfalvi, Ken Mackie, Catherine Ledent, Paula Agostinho, Pedro Garção, Luísa Cortes, Filipe F.M. Teixeira, Samira G. Ferreira
Publikováno v:
Neurochemistry International. 61:219-226
Both the serotonergic and endocannabinoid systems modulate frontocortical glutamate release; thus they are well positioned to participate in the pathogenesis of psychiatric disorders. With the help of fluorescent and confocal microscopy, we localized
Autor:
Nuno J, Machado, Ana Patrícia, Simões, Henrique B, Silva, Ana Paula, Ardais, Manuella P, Kaster, Pedro, Garção, Diana I, Rodrigues, Daniela, Pochmann, Ana Isabel, Santos, Inês M, Araújo, Lisiane O, Porciúncula, Ângelo R, Tomé, Attila, Köfalvi, Jean-Marie, Vaugeois, Paula, Agostinho, Malika, El Yacoubi, Rodrigo A, Cunha, Catarina A, Gomes
Publikováno v:
Molecular neurobiology. 54(2)
Caffeine prophylactically prevents mood and memory impairments through adenosine A