Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Pedro Cisternas"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 566 (2024)
Background: Aging and obesity are associated with insulin resistance (IR) and low-grade inflammation. Molecularly, IR is characterized by a reduction in glucose uptake and insulin signaling (IRS-1/Akt/AS160 pathway), while inflammation may result fro
Externí odkaz:
https://doaj.org/article/982a464d2c5e4e74a1d93dbaa85b5301
Autor:
Pedro Cisternas, Camila Gherardelli, Joel Gutierrez, Paulina Salazar, Carolina Mendez-Orellana, G. William Wong, Nibaldo C. Inestrosa
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Metabolic syndrome (MetS), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk of several aging-related brain diseases, including Alzheimer’s disease (AD). However, the underlying mecha
Externí odkaz:
https://doaj.org/article/6a6e6e8a260442fa857ce0bab68eb2d1
Autor:
Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M. Zolezzi, Nibaldo C. Inestrosa
Publikováno v:
Biological Research, Vol 55, Iss 1, Pp 1-18 (2022)
Abstract Alzheimer’s disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates. Importantly, Aβ and tau species are able to activate astrocytes and micro
Externí odkaz:
https://doaj.org/article/424aeb59d19f4d7bbaa09b827fd93235
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Late onset Alzheimer´s disease (AD) is a neurodegenerative disease with gender differences in its onset and progression, being the prevalence predominant in women and at an earlier age than in men. The pathophysiology of the menopausal condition has
Externí odkaz:
https://doaj.org/article/7f02fc26f5774601adec27ac080e7768
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 15 (2021)
Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia. Although transgenic Alzheimer's disease (AD) animal models have greatly contributed to our understanding of the disease, therapies tested in these
Externí odkaz:
https://doaj.org/article/0b5027f6961a4a398a213bb0c954335f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8733 (2022)
Impaired cerebral glucose metabolism is an early event that contributes to the pathogenesis of Alzheimer’s disease (AD). Importantly, restoring glucose availability by pharmacological agents or genetic manipulation has been shown to protect against
Externí odkaz:
https://doaj.org/article/afcc40fc140749e48f5a8537bc4e3f6d
Autor:
Pedro Cisternas, Carolina A. Oliva, Viviana I. Torres, Daniela P. Barrera, Nibaldo C. Inestrosa
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) is the most common type of dementia. The onset and progression of this pathology are correlated with several changes in the brain, including the formation of extracellular aggregates of amyloid-beta (Aβ) peptide and the in
Externí odkaz:
https://doaj.org/article/3c367bbbf3014386bc890bceafa23ae0
Autor:
Macarena S Arrázola, Eva Ramos-Fernández, Pedro Cisternas, Daniela Ordenes, Nibaldo C Inestrosa
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168840 (2017)
Alzheimer's disease (AD) is a neurodegenerative disorder mainly known for synaptic impairment and neuronal cell loss, affecting memory processes. Beside these damages, mitochondria have been implicated in the pathogenesis of AD through the induction
Externí odkaz:
https://doaj.org/article/ec1023f3b24c41cbb52ffcecd4512b65
Autor:
Pedro Cisternas, Paulina Salazar, Carmen Silva-Álvarez, L. Felipe Barros, Nibaldo C. Inestrosa
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
In the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting a role for this pathway in the control of metabolic flux. Wnt signaling is critical for several neuronal functions, but little is kno
Externí odkaz:
https://doaj.org/article/af228b2a0a764eae85991f14f45bc368
Autor:
Francisco Nualart, Katterine Salazar, Karina Oyarce, Pedro Cisternas, Nery Jara, Carmen Silva-Álvarez, Patricia Pastor, Fernando Martínez, Andrea García, María de los Ángeles García-Robles, Juan Carlos Tapia
Publikováno v:
Biological Research, Vol 45, Iss 3, Pp 243-256 (2012)
Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and differentiate into numerous cell types, including neurons, oligodendrocytes and astrocy
Externí odkaz:
https://doaj.org/article/b2c463651dbb4d69a7e4003aea4bc50f