Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Pedro Brugarolas"'
Publikováno v:
iRADIOLOGY, Vol 2, Iss 3, Pp 339-361 (2024)
Abstract Positron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes. As such, PET can provide important pathophysiological information associ
Externí odkaz:
https://doaj.org/article/4077a0d7880b48b9bcc12d03c97bd2a3
Autor:
Yang Sun, Sofia Rodríguez-Rangel, Lauren L. Zhang, Jorge E. Sánchez-Rodríguez, Pedro Brugarolas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract 4-aminopyridine (4AP) is a potassium (K+) channel blocker used clinically to improve walking in people with multiple sclerosis (MS). 4AP binds to exposed K+ channels in demyelinated axons, reducing the leakage of intracellular K+ and enhanci
Externí odkaz:
https://doaj.org/article/8a987955fe3a4e0c9171560042454acd
Autor:
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [11C]3MeO4AP has shown promise due to
Externí odkaz:
https://doaj.org/article/3d734de69661416e837557c698a2e2cb
Autor:
Felicitas J. Detmer, Nathaniel M. Alpert, Sung-Hyun Moon, Maeva Dhaynaut, J. Luis Guerrero, Nicolas J. Guehl, Fangxu Xing, Pedro Brugarolas, Timothy M. Shoup, Marc D. Normandin, Matthieu Pelletier-Galarneau, Georges El Fakhri, Yoann Petibon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this proof-of-principle study, we investigated whether PET mapping of cardiac membrane potential, an indicator of mitochondrial function, could detect
Externí odkaz:
https://doaj.org/article/45f72c7eae84477dbaf9f917eb1916ed
Autor:
Benayahu Elbaz, Joshua D. Aaker, Sara Isaac, Anna Kolarzyk, Pedro Brugarolas, Amir Eden, Brian Popko
Publikováno v:
Cell Reports, Vol 23, Iss 8, Pp 2254-2263 (2018)
Summary: Zinc finger protein ZFP24, formerly known as ZFP191, is essential for oligodendrocyte maturation and CNS myelination. Nevertheless, the mechanism by which ZFP24 controls these processes is unknown. We demonstrate that ZFP24 binds to a consen
Externí odkaz:
https://doaj.org/article/f80bd64717ff496cb96fa24d1a1a5131
Publikováno v:
Molecular Imaging, Vol 17 (2018)
Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a qua
Externí odkaz:
https://doaj.org/article/fd1cd080e2b2404099938efc8beef81b
Autor:
Yang Sun, Nicolas J. Guehl, Yu-Peng Zhou, Kazue Takahashi, Vasily Belov, Maeva Dhaynaut, Sung-Hyun Moon, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
ACS Chemical Neuroscience. 13:3342-3351
Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In demyelinat
Autor:
Pedro Brugarolas, Moses Q. Wilks, Jacqueline Noel, Julia-Ann Kaiser, Danielle R. Vesper, Karla M. Ramos-Torres, Nicolas J. Guehl, Marina T. Macdonald-Soccorso, Yang Sun, Peter A. Rice, Daniel L. Yokell, Ruth Lim, Marc D. Normandin, Georges El Fakhri
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 50:344-351
Purpose [18F]3F4AP is a novel PET radiotracer that targets voltage-gated potassium (K+) channels and has shown promise for imaging demyelinated lesions in animal models of neurological diseases. This study aimed to evaluate the biodistribution, safet
Autor:
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Sung-Hyun Moon, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
bioRxiv
Purpose4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [11C]3MeO4AP has shown promise due to its high brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867454f1f3179ff092083ff081c1b839
https://europepmc.org/articles/PMC10081174/
https://europepmc.org/articles/PMC10081174/
Autor:
Sanjay Telu, Susovan Jana, Mohammad B. Haskali, Bo Yeun Yang, Jimmy E. Jakobsson, Qunchao Zhao, Karla M. Ramos‐Torres, Pedro Brugarolas, Victor W. Pike
Publikováno v:
Chemistry – A European Journal. 29