Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Pedro Blecua"'
Autor:
Marcelo Lima Ribeiro, Núria Profitós-Pelejà, Juliana Carvalho Santos, Pedro Blecua, Diana Reyes-Garau, Marc Armengol, Miranda Fernández-Serrano, Hari P. Miskin, Francesc Bosch, Manel Esteller, Emmanuel Normant, Gael Roué
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmunotherapy-based regimens have considerably improved the survival rate of B-cell non-Hodgkin lymphoma (B-NHL) patients in the last decades; however, most disease subtypes remain almost incurable. TG-1801, a bispecific antibody that targe
Externí odkaz:
https://doaj.org/article/3517b4cd1e5e41d09c3aadb61e3651bd
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1616-1639 (2020)
The rapid advances in high‐throughput sequencing technologies have made it more evident that epigenetic modifications orchestrate a plethora of complex biological processes. During the last decade, we have gained significant knowledge about a wide
Externí odkaz:
https://doaj.org/article/cc27b87b6b6f47f3acaa165a2c566d5d
Autor:
Fresia Pareja, Alissa H. Brandes, Thais Basili, Pier Selenica, Felipe C. Geyer, Dan Fan, Arnaud Da Cruz Paula, Rahul Kumar, David N. Brown, Rodrigo Gularte-Mérida, Barbara Alemar, Rui Bi, Raymond S. Lim, Ino de Bruijn, Sho Fujisawa, Rui Gardner, Elvin Feng, Anqi Li, Edaise M. da Silva, John R. Lozada, Pedro Blecua, Leona Cohen-Gould, Achim A. Jungbluth, Emad A. Rakha, Ian O. Ellis, Maria I. A. Edelweiss, Juan Palazzo, Larry Norton, Travis Hollmann, Marcia Edelweiss, Brian P. Rubin, Britta Weigelt, Jorge S. Reis-Filho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Granular cell tumors (GCTs) are rare tumors that arise in multiple anatomical locations. Here, the authors investigate the genomics of GCTs, finding inactivating somatic mutations in ATP6AP1 or ATP6AP2 in 72% of the 82 GCTs analyzed. In vitro manipul
Externí odkaz:
https://doaj.org/article/009968388daa46a8b838d3017e34238c
Autor:
Felipe C. Geyer, Anqi Li, Anastasios D. Papanastasiou, Alison Smith, Pier Selenica, Kathleen A. Burke, Marcia Edelweiss, Huei-Chi Wen, Salvatore Piscuoglio, Anne M. Schultheis, Luciano G. Martelotto, Fresia Pareja, Rahul Kumar, Alissa Brandes, Dan Fan, Thais Basili, Arnaud Da Cruz Paula, John R. Lozada, Pedro Blecua, Simone Muenst, Achim A. Jungbluth, Maria P. Foschini, Hannah Y. Wen, Edi Brogi, Juan Palazzo, Brian P. Rubin, Charlotte K. Y. Ng, Larry Norton, Zsuzsanna Varga, Ian O. Ellis, Emad A. Rakha, Sarat Chandarlapaty, Britta Weigelt, Jorge S. Reis-Filho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Adenomyoepithelioma is a rare tumor of the breast with an unknown genetic basis. Here the authors perform a genomic analysis of adenomyoepitheliomas revealing that their repertoire of somatic mutations vary according to the estrogen receptor (ER) sta
Externí odkaz:
https://doaj.org/article/542cf17a65664524a59e8d4c4c40fa5e
Autor:
Nadeem Riaz, Pedro Blecua, Raymond S. Lim, Ronglai Shen, Daniel S. Higginson, Nils Weinhold, Larry Norton, Britta Weigelt, Simon N. Powell, Jorge S. Reis-Filho
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer. Here, the authors show that mutually exclusive bi-allelic inactivation of HR genes are present in other cancer types and associated with gen
Externí odkaz:
https://doaj.org/article/e31117fa0ba445099c2675a88b60cb9a
Autor:
Selina Chen-Kiang, John P. Leonard, Christopher E. Mason, Olivier Elemento, Scott Ely, Betty Chang, Amy Johnson, Siraj Ali, Ken Eng, Priyanka Vijay, Susan Mathew, Pedro Blecua, Jeff Sharman, Xiangao Huang, Peter Martin, Maurizio Di Liberto, David Chiron
Significant non-synonymous damaging SNVs detected in CDS by targeted exome sequencing in Pt 2 relapse sample.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050ea228bec608ef0334889577ff68c1
https://doi.org/10.1158/2159-8290.22532134.v1
https://doi.org/10.1158/2159-8290.22532134.v1
Autor:
Selina Chen-Kiang, John P. Leonard, Christopher E. Mason, Olivier Elemento, Scott Ely, Betty Chang, Amy Johnson, Siraj Ali, Ken Eng, Priyanka Vijay, Susan Mathew, Pedro Blecua, Jeff Sharman, Xiangao Huang, Peter Martin, Maurizio Di Liberto, David Chiron
Figure S1. MCL cell lines are differentially sensitive to killing and cell cycle control by ibrutinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3238466bb9477978c0a21c4b9b98fa3e
https://doi.org/10.1158/2159-8290.22532152.v1
https://doi.org/10.1158/2159-8290.22532152.v1
Autor:
Pedro Blecua, Veronica Davalos, Izar de Villasante, Angelika Merkel, Eva Musulen, Laia Coll-SanMartin, Manel Esteller
Publikováno v:
Briefings in Bioinformatics
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
High-throughput genomic technologies are increasingly used in personalized cancer medicine. However, computational tools to maximize the use of scarce tissues combining distinct molecular layers are needed. Here we present a refined strategy, based o
Autor:
Juan J. Alburquerque-Bejar, Pablo Navajas-Chocarro, Maria Saigi, Ana Ferrero-Andres, Juan M. Morillas, Andrea Vilarrubi, Antonio Gomez, José L. Mate, Ana M. Munoz-Marmol, Octavio A. Romero, Pedro Blecua, Veronica Davalos, Manel Esteller, Eva Pros, Paula Llabata, Manuel Torres-Diz, Anna Esteve-Codina, Montse Sanchez-Cespedes
Publikováno v:
Cell Reports Medicine. 4:101006
Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-γ (IFNγ), a cytok
Autor:
Pedro Blecua Carrillo Albornoz, Timothy A. Chan, Rajarsi Mandal, Qing Chang, Vladimir Makarov, Raghvendra M. Srivastava, Tanaya A. Purohit, Besnik Qeriqi, Simon N. Powell, Britta Weigelt, Elisa de Stanchina, Jeremy Setton, Jonathan H. Chung, Luc G. T. Morris, Robert M. Samstein, Ken-Wing Lee, Xin Pei, Rachna Shah, Lior Z. Braunstein, Xiaoxiao Ma, Sviatoslav M. Kendall, Douglas R. Hoen, Jorge S. Reis-Filho, Nadeem Riaz, Wei Wu, Diana Mandelker, Chirag Krishna, Fengshen Kuo
Publikováno v:
Nature Cancer. 1:1188-1203
Immune checkpoint blockade (ICB) has improved outcomes for patients with advanced cancer, but the determinants of response remain poorly understood. Here we report differential effects of mutations in the homologous recombination genes BRCA1 and BRCA