Zobrazeno 1 - 10
of 657
pro vyhledávání: '"Pedro A. Ruiz"'
Autor:
Cheryl de Vallière, Katharina Bäbler, Philipp Busenhart, Marlene Schwarzfischer, Chiaki Maeyashiki, Cordelia Schuler, Kirstin Atrott, Silvia Lang, Marianne R. Spalinger, Michael Scharl, Pedro A. Ruiz-Castro, Martin Hausmann, Gerhard Rogler
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-14 (2021)
Background and Aims: Local extracellular acidification is associated with several conditions, such as ischemia, cancer, metabolic disease, respiratory diseases, and inflammatory bowel disease (IBD). Several recent studies reported a link between IBD
Externí odkaz:
https://doaj.org/article/9b79683e8b92491caaad15387242bfbd
Autor:
Pedro A. Ruiz Castro, Hasmik Yepiskoposyan, Sylvain Gubian, Florian Calvino-Martin, Ulrike Kogel, Kasper Renggli, Manuel C. Peitsch, Julia Hoeng, Marja Talikka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The molecular mechanisms of IBD have been the subject of intensive exploration. We, therefore, assembled the available information into a suite of causal biological network models, which offer comprehensive visualization of the processes und
Externí odkaz:
https://doaj.org/article/5020808525844ce6a5169f204e832fcc
Autor:
Simona Simmen, Max Maane, Sarah Rogler, Katherina Baebler, Silvia Lang, Jesus Cosin-Roger, Kirstin Atrott, Isabelle Frey-Wagner, Partick Spielmann, Roland H. Wenger, Bruce Weder, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Cheryl de Vallière, Martin Hausmann, Pedro A. Ruiz
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-14 (2021)
Introduction: Intestinal fibrosis, characterized by excessive deposition of extracellular matrix proteins, is a common and severe clinical complication of inflammatory bowel disease (IBD). However, the mechanisms underlying fibrosis remain elusive, a
Externí odkaz:
https://doaj.org/article/d64d1537f9a94c2ab49ba22fe8d8e8b2
Autor:
Pedro A. Ruiz Castro, Ulrike Kogel, Giuseppe Lo Sasso, Blaine W. Phillips, Alain Sewer, Bjorn Titz, Llenalia Garcia, Athanasios Kondylis, Emmanuel Guedj, Dariusz Peric, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng
Publikováno v:
Journal of Inflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and including two main disease
Externí odkaz:
https://doaj.org/article/2e427f6c610a4c23ad233756dbe31804
Autor:
Simona Simmen, Jesus Cosin-Roger, Hassan Melhem, Nikolaos Maliachovas, Max Maane, Katharina Baebler, Bruce Weder, Chiaki Maeyashiki, Katharina Spanaus, Michael Scharl, Cheryl de Vallière, Jonas Zeitz, Stephan R. Vavricka, Martin Hausmann, Gerhard Rogler, Pedro A. Ruiz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 339-355 (2019)
Background & Aims: Hypoxia-associated pathways influence the development of inflammatory bowel disease. Adaptive responses to hypoxia are mediated through hypoxia-inducible factors, which are regulated by iron-dependent hydroxylases. Signals reflecti
Externí odkaz:
https://doaj.org/article/e18615abd3a84736a51a82565582a10a
Autor:
Irina V. Tcymbarevich, Jyrki J. Eloranta, Jean-Benoît Rossel, Nicole Obialo, Marianne Spalinger, Jesus Cosin-Roger, Silvia Lang, Gerd A. Kullak-Ublick, Carsten A. Wagner, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Gerhard Rogler, Cheryl de Vallière, Benjamin Misselwitz, on behalf of the Swiss IBD Cohort Study Group
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In respons
Externí odkaz:
https://doaj.org/article/6941ccbb826442539db66cc0037811fa
Autor:
Diego Marescotti, Giuseppe Lo Sasso, Diego Guerrera, Kasper Renggli, Pedro A. Ruiz Castro, Romain Piault, Vincent Jaquet, Fabian Moine, Karsta Luettich, Stefan Frentzel, Manuel C. Peitsch, Julia Hoeng
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Intestinal inflammation is the collective term for immune system-mediated diseases of unknown, multifactorial etiology, with often complex interactions between genetic and environmental factors. To mechanistically investigate the effect of treatment
Externí odkaz:
https://doaj.org/article/cb879808892a44e488d64d56652c847c
Autor:
Jesus Cosin-Roger, Simona Simmen, Hassan Melhem, Kirstin Atrott, Isabelle Frey-Wagner, Martin Hausmann, Cheryl de Vallière, Marianne R. Spalinger, Patrick Spielmann, Roland H. Wenger, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Pedro A. Ruiz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting
Externí odkaz:
https://doaj.org/article/ec822dd8ef504b80b17abfefcd2b752a
Autor:
Cheryl de Vallière, Jesus Cosin-Roger, Simona Simmen, Kirstin Atrott, Hassan Melhem, Jonas Zeitz, Mehdi Madanchi, Irina Tcymbarevich, Michael Fried, Gerd A. Kullak-Ublick, Stephan R. Vavricka, Benjamin Misselwitz, Klaus Seuwen, Carsten A. Wagner, Jyrki J. Eloranta, Gerhard Rogler, Pedro A. Ruiz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 6, Pp 796-810 (2016)
Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a re
Externí odkaz:
https://doaj.org/article/7a3bd9560e9e42fda27043e39740354d
Autor:
Eugenia Becker, Susan Bengs, Sirisha Aluri, Lennart Opitz, Kirstin Atrott, Felix Rost, Irina Leonardi, Claudia Stanzel, Tina Raselli, Stephanie Kasper, Pedro A. Ruiz, Gerhard Rogler
Publikováno v:
Epigenomes, Vol 1, Iss 3, p 24 (2017)
Environmental factors are playing a central role in triggering inflammatory responses in the intestine. There is increasing evidence that the development of inflammatory bowel disease (IBD) is deriving from an aberrant immune response to the commensa
Externí odkaz:
https://doaj.org/article/01a89844782647a1bf916d78f76abbff