Výsledky vyhledávání - "Pedro A. Pérez-Mancera"

Akademický článek

A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma—Toward a Better Mimicry of the in vivo Tumor Microenvironment

Autor: Priyanka Gupta, Pedro A. Pérez-Mancera, Hemant Kocher, Andrew Nisbet, Giuseppe Schettino, Eirini G. Velliou

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)

With a very low survival rate, pancreatic ductal adenocarcinoma (PDAC) is a deadly disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance to current treatment methods. The latter specifically requires the d

Externí odkaz: https://doaj.org/article/81e8a19adb4d4d8ea870c3e98e1dbf14

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What We Have Learned About Pancreatic Cancer From Mouse Models

Autor: David A. Tuveson, Carmen Guerra, Pedro A. Pérez–Mancera, Mariano Barbacid

Publikováno v: Gastroenterology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1c272e63ed40ff27ff84b417504b75
https://doi.org/10.1053/j.gastro.2012.03.002

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SLUG (SNAI2) overexpression in embryonic development

Autor: Cristina Robledo, M.-Y. Yip, Kenneth N. Maclean, Pedro A. Pérez-Mancera, Juan Luis García, Alfonso Gutiérrez-Adán, Inés González-Herrero, Isidro Sánchez-García, Anne M. Turner, T. Flores, Manuel Sánchez-Martín, Belén Pintado

Publikováno v: Cytogenetic and Genome Research. 114:24-29

The Snail-related zinc-finger transcription factor, SLUG (SNAI2), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to cause piebaldism and Waardenburg syndrome type 2 in a dose-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e62a85d8873a84a5c806d35929e3576
https://doi.org/10.1159/000091924

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Liposarcoma initiated by FUS/TLS-CHOP: the FUS/TLS domain plays a critical role in the pathogenesis of liposarcoma

Autor: Pedro A. Pérez-Mancera, Teresa Flores, Isidro Sánchez-García, E Battaner, Jesús Pérez-Losada, Belén Pintado, Manuel Sánchez-Martín, M A Rodríguez-García

Publikováno v: Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
Digital.CSIC. Repositorio Institucional del CSIC
instname
INIA: Repositorio de Resultados de Investigación del INIA

The most common chromosomal translocation in liposarcomas, t(12;16)(q13;p11), creates the FUS/TLS-CHOP fusion gene. We previously developed a mouse model of liposarcoma by expressing FUS-CHOP in murine mesenchymal stem cells. In order to understand h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa5977efdfab8991e84a60eb039b5e6
https://doi.org/10.1038/sj.onc.1204018

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FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E

Autor: Isidro Sánchez-García, Camino Bermejo-Rodríguez, Fernando Abollo-Jiménez, Belén Pintado, Manuel Sánchez-Martín, Pedro A. Pérez-Mancera

Publikováno v: PLoS ONE, Vol 3, Iss 7, p e2569 (2008)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname

FUS-DDIT3 is a chimeric protein generated by the most common chromosomal translocation t(12;16)(q13;p11) linked to liposarcomas, which are characterized by the accumulation of early adipocytic precursors. Current studies indicate that FUS-DDIT3- lipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158f6926bff2a881251190135d23c80a
http://europepmc.org/articles/PMC2434200?pdf=render

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Physiological analysis of oncogenic K-ras

Autor: Pedro Antonio, Pérez-Mancera, David A, Tuveson

Publikováno v: Methods in enzymology. 407

Although activating mutations in KRAS are identified in most pancreatic cancers and a large number of other neoplasms, our understanding of the precise molecular and cellular mechanisms that constitute the oncogenic effects of mutant KRAS has been in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a308fd06d419dd599970eefd30264372
https://pubmed.ncbi.nlm.nih.gov/16757361

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Cancer development induced by graded expression of Snail in mice

Autor: Alberto Orfao, Pedro A. Pérez-Mancera, Manuel Sánchez-Martín, Isidro Sánchez-García, Alfonso Gutiérrez-Adán, Ana Sagrera, Inés González-Herrero, Teresa Flores, A. Garcia de Herreros, Belén Pintado, Maria Perez-Caro

The zinc-finger transcription factor Snail is believed to trigger epithelial-mesenchymal transitions (EMTs) during cancer progression. This idea is supported by analysis of Snail knockout mice, which uncovered crucial role of Snail in gastrulation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1429e2d3f2eb5031a0f5bfb3c869d697
https://pubmed.ncbi.nlm.nih.gov/16207734

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Of man in mouse: modelling human cancer genotype-phenotype correlations in mice

Autor: Maria Perez-Caro, Isidro Sánchez-García, Pedro A. Pérez-Mancera, Felipe Voces

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

To date, many genetic changes have been described and reported in the cancer process. Since the first mutations were described, several attempts to establish genotype-phenotype correlations for these genetic alterations have been reported. Moreover,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ca677f93e3abf61a3b9bc3c9eeec69
http://hdl.handle.net/10261/6269

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SLUG in cancer development

Autor: Isidro Sánchez-García, Manuel Sánchez-Martín, Pedro A. Pérez-Mancera, Teresa Flores, Inés González-Herrero, Belén Pintado, Alfonso Gutiérrez-Adán, N. Gutierrez-Cianca, Maria Perez-Caro

The SNAIL-related zinc-finger transcription factor, SLUG (SNAI2), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to contribute to piebaldism and Waardenburg syndrome type 2 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4eb8843e0c41d8ac0e663d708aa3c9
http://hdl.handle.net/10261/6267

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