Zobrazeno 1 - 10 of 67 pro vyhledávání: '"Pedro A Sánchez-Murcia"'
1
Akademický článek
Vibrio cholerae’s ToxRS bile sensing system
Autor: Nina Gubensäk, Theo Sagmeister, Christoph Buhlheller, Bruno Di Geronimo, Gabriel E Wagner, Lukas Petrowitsch, Melissa A Gräwert, Markus Rotzinger, Tamara M Ismael Berger, Jan Schäfer, Isabel Usón, Joachim Reidl, Pedro A Sánchez-Murcia, Klaus Zangger, Tea Pavkov-Keller
Publikováno v: eLife, Vol 12 (2023)
The seventh pandemic of the diarrheal cholera disease, which began in 1960, is caused by the Gram-negative bacterium Vibrio cholerae. Its environmental persistence provoking recurring sudden outbreaks is enabled by V. cholerae’s rapid adaption to c
Externí odkaz: https://doaj.org/article/14240b0ac4a54de397f1b6609f309fb1
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2
Akademický článek
Insights into the Biological Activity and Bio‐Interaction Properties of Nanoscale Imine‐Based 2D and 3D Covalent Organic Frameworks
Autor: Hao Ye, Carlos Franco, Mostafa A. Aboouf, Markus Thiersch, Semih Sevim, Joaquin Llacer‐Wintle, Andrea Veciana, Gemma Llauradó‐Capdevila, Kaiyuan Wang, Xiang‐Zhong Chen, Qiao Tang, Roc Matheu, Pedro D. Wendel‐Garcia, Pedro A. Sánchez‐Murcia, Bradley J. Nelson, Cong Luo, Josep Puigmartí‐Luis, Salvador Pané
Publikováno v: Advanced Science, Vol 11, Iss 44, Pp n/a-n/a (2024)
Abstract Covalent Organic Frameworks (COFs) emerged as versatile materials with promising potential in biomedicine. Their customizable functionalities and tunable pore structures make them valuable for various biomedical applications such as biosensi
Externí odkaz: https://doaj.org/article/973da5b2b1164c5fae8f320e4c91d055
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3
Akademický článek
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
Autor: Emil Spreitzer, T. Reid Alderson, Benjamin Bourgeois, Loretta Eggenreich, Hermann Habacher, Greta Bramerdorfer, Iva Pritišanac, Pedro A. Sánchez-Murcia, Tobias Madl
Publikováno v: Current Research in Structural Biology, Vol 4, Iss , Pp 118-133 (2022)
Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families. Among them, the
Externí odkaz: https://doaj.org/article/7f409bd87d6e4290a919dff475fc1900
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4
Akademický článek
Molecular Basis of NDT-Mediated Activation of Nucleoside-Based Prodrugs and Application in Suicide Gene Therapy
Autor: Javier Acosta, Elena Pérez, Pedro A. Sánchez-Murcia, Cristina Fillat, Jesús Fernández-Lucas
Publikováno v: Biomolecules, Vol 11, Iss 1, p 120 (2021)
Herein we report the first proof for the application of type II 2′-deoxyribosyltransferase from Lactobacillus delbrueckii (LdNDT) in suicide gene therapy for cancer treatment. To this end, we first confirm the hydrolytic ability of LdNDT over the n
Externí odkaz: https://doaj.org/article/1c63233fbb5d40ebad3071c5ac28aeb3
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6
Prediction of enzyme catalysis by computing reaction energy barriers via steered QM/MM Molecular Dynamics Simulations and Machine Learning
Autor: Daniel Platero-Rochart, Tatyana Krivobokova, Michael Gastegger, Gilbert Reibnegger, Pedro Alejandro Sánchez-Murcia
The prediction of enzyme activity in a general extend is maybe one of the main challenges nowadays in catalysis. Computer-assisted methods have been proven to be able to simulate the reaction mechanism at the atomic level of detail. However, these me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdd4f533d758ffb255e3da143e872337
https://doi.org/10.26434/chemrxiv-2023-v0rj6
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8
Akademický článek
Functional Characterization and Structural Analysis of NADH Oxidase Mutants from Thermus thermophilus HB27: Role of Residues 166, 174, and 194 in the Catalytic Properties and Thermostability
Autor: Javier Rocha-Martin, Pedro A. Sánchez-Murcia, Fernando López-Gallego, Aurelio Hidalgo, José Berenguer, José M. Guisan
Publikováno v: Microorganisms, Vol 7, Iss 11, p 515 (2019)
The Thermus thermophilus strain HB27 NADH-oxidase (Tt27-NOX) catalyzes the oxidation of nicotinamide adenine dinucleotide (NAD(P)H) by reducing molecular oxygen to hydrogen peroxide in a two-electron transfer mechanism. Surprisingly, Tt27-NOX showed
Externí odkaz: https://doaj.org/article/4acb424d355d4dfa82c3da5d470f3b16
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9
Deciphering the Chemical Basis of Fluorescence of a Selenium-Labeled Uracil Probe when Bound at the Bacterial Ribosomal A-Site
Autor: Nicolás Ramos-Berdullas, Pedro A. Sánchez-Murcia, Gustavo Cárdenas, Maximilian F. S. J. Menger
Publikováno v: Chemistry-A European Journal, 27(15), 4927-4931. Wiley-VCH Verlag GmbH & Co. KGaA
We unveil in this work the main factors that govern the turn-on/off fluorescence of a Se-modified uracil probe at the ribosomal RNA A-site. Whereas the constraint into an “in-plane” conformation of the two rings of the fluorophore is the main dri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba10ac0c361abe7bd35ba3c03d96bcc0
https://research.rug.nl/en/publications/bc0d9b40-7e67-4b46-9c15-9addfa400491
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