Výsledky vyhledávání - "Pedro A Pérez-Mancera"

Akademický článek

Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.

Autor: Kristina Kirschner, Shamith A Samarajiwa, Jonathan M Cairns, Suraj Menon, Pedro A Pérez-Mancera, Kosuke Tomimatsu, Camino Bermejo-Rodriguez, Yoko Ito, Tamir Chandra, Masako Narita, Scott K Lyons, Andy G Lynch, Hiroshi Kimura, Tetsuya Ohbayashi, Simon Tavaré, Masashi Narita

Publikováno v: PLoS Genetics, Vol 11, Iss 3, p e1005053 (2015)

The downstream functions of the DNA binding tumor suppressor p53 vary depending on the cellular context, and persistent p53 activation has recently been implicated in tumor suppression and senescence. However, genome-wide information about p53-target

Externí odkaz: https://doaj.org/article/95bf5319b4d1437988034a2c649835a8

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Akademický článek

FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E.

Autor: Pedro A Pérez-Mancera, Camino Bermejo-Rodríguez, Manuel Sánchez-Martín, Fernando Abollo-Jiménez, Belén Pintado, Isidro Sánchez-García

Publikováno v: PLoS ONE, Vol 3, Iss 7, p e2569 (2008)

BACKGROUND: FUS-DDIT3 is a chimeric protein generated by the most common chromosomal translocation t(12;16)(q13;p11) linked to liposarcomas, which are characterized by the accumulation of early adipocytic precursors. Current studies indicate that FUS

Externí odkaz: https://doaj.org/article/8a43dcb74a1d42a896026f6a5842b877

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A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma-Toward a Better Mimicry of the

Autor: Priyanka, Gupta, Pedro A, Pérez-Mancera, Hemant, Kocher, Andrew, Nisbet, Giuseppe, Schettino, Eirini G, Velliou

Publikováno v: Frontiers in Bioengineering and Biotechnology

With a very low survival rate, pancreatic ductal adenocarcinoma (PDAC) is a deadly disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance to current treatment methods. The latter specifically requires the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ef629e58b3ad1e7efac33c2282e6751
https://pubmed.ncbi.nlm.nih.gov/32391339

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What We Have Learned About Pancreatic Cancer From Mouse Models

Autor: David A. Tuveson, Carmen Guerra, Pedro A. Pérez–Mancera, Mariano Barbacid

Publikováno v: Gastroenterology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1c272e63ed40ff27ff84b417504b75
https://doi.org/10.1053/j.gastro.2012.03.002

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SLUG (SNAI2) overexpression in embryonic development

Autor: Cristina Robledo, M.-Y. Yip, Kenneth N. Maclean, Pedro A. Pérez-Mancera, Juan Luis García, Alfonso Gutiérrez-Adán, Inés González-Herrero, Isidro Sánchez-García, Anne M. Turner, T. Flores, Manuel Sánchez-Martín, Belén Pintado

Publikováno v: Cytogenetic and Genome Research. 114:24-29

The Snail-related zinc-finger transcription factor, SLUG (SNAI2), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to cause piebaldism and Waardenburg syndrome type 2 in a dose-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e62a85d8873a84a5c806d35929e3576
https://doi.org/10.1159/000091924

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Liposarcoma initiated by FUS/TLS-CHOP: the FUS/TLS domain plays a critical role in the pathogenesis of liposarcoma

Autor: Pedro A. Pérez-Mancera, Teresa Flores, Isidro Sánchez-García, E Battaner, Jesús Pérez-Losada, Belén Pintado, Manuel Sánchez-Martín, M A Rodríguez-García

Publikováno v: Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
Digital.CSIC. Repositorio Institucional del CSIC
instname
INIA: Repositorio de Resultados de Investigación del INIA

The most common chromosomal translocation in liposarcomas, t(12;16)(q13;p11), creates the FUS/TLS-CHOP fusion gene. We previously developed a mouse model of liposarcoma by expressing FUS-CHOP in murine mesenchymal stem cells. In order to understand h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa5977efdfab8991e84a60eb039b5e6
https://doi.org/10.1038/sj.onc.1204018

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FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E

Autor: Isidro Sánchez-García, Camino Bermejo-Rodríguez, Fernando Abollo-Jiménez, Belén Pintado, Manuel Sánchez-Martín, Pedro A. Pérez-Mancera

Publikováno v: PLoS ONE, Vol 3, Iss 7, p e2569 (2008)
PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname

FUS-DDIT3 is a chimeric protein generated by the most common chromosomal translocation t(12;16)(q13;p11) linked to liposarcomas, which are characterized by the accumulation of early adipocytic precursors. Current studies indicate that FUS-DDIT3- lipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158f6926bff2a881251190135d23c80a
http://europepmc.org/articles/PMC2434200?pdf=render

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Physiological analysis of oncogenic K-ras

Autor: Pedro Antonio, Pérez-Mancera, David A, Tuveson

Publikováno v: Methods in enzymology. 407

Although activating mutations in KRAS are identified in most pancreatic cancers and a large number of other neoplasms, our understanding of the precise molecular and cellular mechanisms that constitute the oncogenic effects of mutant KRAS has been in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a308fd06d419dd599970eefd30264372
https://pubmed.ncbi.nlm.nih.gov/16757361

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Cancer development induced by graded expression of Snail in mice

Autor: Alberto Orfao, Pedro A. Pérez-Mancera, Manuel Sánchez-Martín, Isidro Sánchez-García, Alfonso Gutiérrez-Adán, Ana Sagrera, Inés González-Herrero, Teresa Flores, A. Garcia de Herreros, Belén Pintado, Maria Perez-Caro

The zinc-finger transcription factor Snail is believed to trigger epithelial-mesenchymal transitions (EMTs) during cancer progression. This idea is supported by analysis of Snail knockout mice, which uncovered crucial role of Snail in gastrulation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1429e2d3f2eb5031a0f5bfb3c869d697
https://pubmed.ncbi.nlm.nih.gov/16207734

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Of man in mouse: modelling human cancer genotype-phenotype correlations in mice

Autor: Maria Perez-Caro, Isidro Sánchez-García, Pedro A. Pérez-Mancera, Felipe Voces

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

To date, many genetic changes have been described and reported in the cancer process. Since the first mutations were described, several attempts to establish genotype-phenotype correlations for these genetic alterations have been reported. Moreover,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ca677f93e3abf61a3b9bc3c9eeec69
http://hdl.handle.net/10261/6269

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