Zobrazeno 1 - 10
of 467
pro vyhledávání: '"Pedro A, Lazo"'
Autor:
Pedro A. Lazo
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
In the nucleus, the VRK1 Ser-Thr kinase is distributed in nucleoplasm and chromatin, where it has different roles. VRK1 expression increases in response to mitogenic signals. VRK1 regulates cyclin D1 expression at G0 exit and facilitates chromosome c
Externí odkaz:
https://doaj.org/article/203b8bd58c1644268ff8c22d62892359
Autor:
Eva Monte-Serrano, Patricia Morejón-García, Ignacio Campillo-Marcos, Aurora Campos-Díaz, Elena Navarro-Carrasco, Pedro A. Lazo
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-20 (2023)
Abstract Background Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions.
Externí odkaz:
https://doaj.org/article/676b1382522c4af5bf97929acd574fdf
Autor:
Pedro A. Lazo, Patricia Morejón-García
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106172- (2023)
Distal hereditary neuropathies and neuro motor diseases are complex neurological phenotypes associated with pathogenic variants in a large number of genes, but in some the origin is unknown. Recently, rare pathogenic variants of the human VRK1 gene h
Externí odkaz:
https://doaj.org/article/961a88f980c643f2af17040a7e67e78f
Autor:
Juan L. García-Hernández, Luis A. Corchete, Íñigo Marcos-Alcalde, Paulino Gómez-Puertas, Carmen Fons, Pedro A. Lazo
Publikováno v:
Human Genomics, Vol 15, Iss 1, Pp 1-11 (2021)
Abstract Background Complex developmental encephalopathy syndromes might be the consequence of unknown genetic alterations that are likely to contribute to the full neurological phenotype as a consequence of pathogenic gene combinations. Methods To i
Externí odkaz:
https://doaj.org/article/1e7d521c22ca40d9b075d128f52b3343
Autor:
Ana T. Marcos, Elena Martín‐Doncel, Patricia Morejón‐García, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, María Segura‐Puimedon, Lluis Armengol, José M. Navarro‐Pando, Pedro A. Lazo
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 808-818 (2020)
Abstract Background Distal motor neuropathies with a genetic origin have a heterogeneous clinical presentation with overlapping features affecting distal nerves and including spinal muscular atrophies and amyotrophic lateral sclerosis. This indicates
Externí odkaz:
https://doaj.org/article/7cf516f40dbd4c2b8556d818786af3d0
Autor:
Ignacio Campillo-Marcos, Eva Monte-Serrano, Elena Navarro-Carrasco, Raúl García-González, Pedro A. Lazo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundChromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). This adaptation requires DNA and histone epigenetic modifications, which are mediated by several types of enzymes; among them ar
Externí odkaz:
https://doaj.org/article/b6ecc03d978141a6964175a15dcf37b4
Autor:
Ignacio Campillo-Marcos, Pedro A. Lazo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)
Abstract Background The VRK1 chromatin kinase regulates the organization of locally altered chromatin induced by DNA damage. The combination of ionizing radiation with inhibitors of DNA damage responses increases the accumulation of DNA damage in can
Externí odkaz:
https://doaj.org/article/049e476af3b74c6ebd059eaf2d0fbf53
Autor:
Elena Navarro-Carrasco, Pedro A. Lazo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundGlioblastomas treated with temozolomide frequently develop resistance to pharmacological treatments. Therefore, there is a need to find alternative drug targets to reduce treatment resistance based on tumor dependencies. A possibility is to
Externí odkaz:
https://doaj.org/article/414e13ba78dd401e9049bd391913ec1c
Autor:
Raúl García-González, Pedro A. Lazo, Elena Navarro-Carrasco, PATRICIA MOREJON, Eva Monte Serrano
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1865(8)
The regulation of histone epigenetic modifications mediates the adaptation of chromatin to different biological processes. DNA damage causes a local relaxation of chromatin associated to histone H4 acetylation in K16, mediated by Tip60/KAT5. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c313a917c73a819b36331cbbd83ab05
https://pubmed.ncbi.nlm.nih.gov/36280132
https://pubmed.ncbi.nlm.nih.gov/36280132
Autor:
Pedro A. Lazo
Synthetic lethality strategies are likely to be integrated in effective and specific cancer treatments. These strategies combine different specific targets, either in similar or cooperating pathways. Chromatin remodeling underlies, directly or indire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed06ad81e4250c87930ffd85f91445a
http://hdl.handle.net/10261/283391
http://hdl.handle.net/10261/283391
