Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Pedro, Miura"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Nervous system development is associated with extensive regulation of alternative splicing (AS) and alternative polyadenylation (APA). AS and APA have been extensively studied in isolation, but little is known about how these processes are c
Externí odkaz:
https://doaj.org/article/cd8d36d90cdc4e2dbf27a28028e3bdf0
Autor:
Bongmin Bae, Pedro Miura
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Alternative cleavage and polyadenylation (APA) is pervasive, occurring for more than 70% of human and mouse genes. Distal poly(A) site selection to generate longer 3′ UTR mRNA isoforms is prevalent in the nervous system, affecting thousands of gene
Externí odkaz:
https://doaj.org/article/5e3b85b6b1ba47aaa713fa67f3fe8ff6
Autor:
Mariela Cortés-López, Matthew R. Gruner, Daphne A. Cooper, Hannah N. Gruner, Alexandru-Ioan Voda, Alexander M. van der Linden, Pedro Miura
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Circular RNAs (CircRNAs) are a newly appreciated class of RNAs that lack free 5′ and 3′ ends, are expressed by the thousands in diverse forms of life, and are mostly of enigmatic function. Ostensibly due to their resistance to
Externí odkaz:
https://doaj.org/article/adf20fbaebe24b21b49384f887d665ee
Autor:
Hana Hall, Patrick Medina, Daphne A. Cooper, Spencer E. Escobedo, Jeremiah Rounds, Kaelan J. Brennan, Christopher Vincent, Pedro Miura, Rebecca Doerge, Vikki M. Weake
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background Aging is associated with functional decline of neurons and increased incidence of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila melanogaster provide a powerful model for studying the molecular chan
Externí odkaz:
https://doaj.org/article/4ce92f48e9694b1e8b4132fe5fa8726d
Autor:
Zhiping Zhang, Kevin So, Ryan Peterson, Matthew Bauer, Henry Ng, Yong Zhang, Jung Hwan Kim, Thomas Kidd, Pedro Miura
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3808-3817.e7 (2019)
Summary: Many metazoan genes express alternative long 3′ UTR isoforms in the nervous system, but their functions remain largely unclear. In Drosophila melanogaster, the Dscam1 gene generates short and long (Dscam1-L) 3′ UTR isoforms because of al
Externí odkaz:
https://doaj.org/article/a12d0f3ed21644729ac989a5619d844b
Autor:
Alec A. Brennan, Anthony Harrington, Mingzhe Guo, Clay P. Renshaw, Richard L. Tillett, Pedro Miura, Yftah Tal-Gan
Publikováno v:
Microbiology (Reading)
Streptococcus sinensis is a recently identified member of the Mitis group of streptococci. This species has been associated with infective endocarditis; however its mechanisms of pathogenesis and virulence are not fully understood. This study aimed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0c5f038d24fe20297649549b5d30f3
https://doi.org/10.1099/mic.0.001256
https://doi.org/10.1099/mic.0.001256
Autor:
Wenxuan Liu, Alanna Klose, Sophie Forman, Nicole D Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, Morgan Flaherty, Pedro Miura, Robert T Dirksen, Joe V Chakkalakal
Publikováno v:
eLife, Vol 6 (2017)
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in respon
Externí odkaz:
https://doaj.org/article/378451325042469199ba48d1d765b206
Autor:
Jakub O. Westholm, Pedro Miura, Sara Olson, Sol Shenker, Brian Joseph, Piero Sanfilippo, Susan E. Celniker, Brenton R. Graveley, Eric C. Lai
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1966-1980 (2014)
Summary: Circularization was recently recognized to broadly expand transcriptome complexity. Here, we exploit massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >100 libraries covering diverse developmental stages, tissues
Externí odkaz:
https://doaj.org/article/fe79549a28ff41f09b8c144dc74c610f
Autor:
Bongmin Bae, Ting Feng, Hannah N. Gruner, Grant S. Mastick, Wei Yan, Kevin So, Simon Pieraut, Daniel Oliver, Pedro Miura, Maebh Lynch
Publikováno v:
RNA. 26:1414-1430
The majority of mouse and human genes are subject to alternative cleavage and polyadenylation (APA), which most often leads to the expression of two or more alternative length 3′ untranslated region (3′-UTR) mRNA isoforms. In neural tissues, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77720836976ff84f6ed373fb47a776e6
https://doi.org/10.1261/rna.076430.120
https://doi.org/10.1261/rna.076430.120
Autor:
David Knupp, Brian G. Jorgensen, Hussam Z. Alshareef, Jaffar M. Bhat, Jeremy J. Grubbs, Pedro Miura, Alexander M. van der Linden
Publikováno v:
Aging Cell. 21
Accumulation of circular RNAs (circRNAs) during aging occurs on a genome-wide level for multiple organisms, but its significance is unknown. Generating circRNA loss-of-function mutants is difficult because the vast majority of these RNAs are comprise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a2526c1e3f8c78a76336a9798c11d4
https://doi.org/10.1111/acel.13560
https://doi.org/10.1111/acel.13560