Výsledky vyhledávání - "Pedro, Lobos"

Akademický článek

Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels

Autor: Ismael Valdés-Undurraga, Pedro Lobos, Virginia Sánchez-Robledo, Alejandra Arias-Cavieres, Carol D. SanMartín, Genaro Barrientos, Jamileth More, Pablo Muñoz, Andrea Cristina Paula-Lima, Cecilia Hidalgo, Tatiana Adasme

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Introduction: Neuronal Ca2+ signals generated through the activation of Ca2+-induced Ca2+ release in response to activity-generated Ca2+ influx play a significant role in hippocampal synaptic plasticity, spatial learning, and memory. We and others ha

Externí odkaz: https://doaj.org/article/2225fa91f74c48159a26b4005ba3f2ba

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Akademický článek

Amyloid β-Oligomers Inhibit the Nuclear Ca2+ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons

Autor: Pedro Lobos, Ignacio Vega-Vásquez, Barbara Bruna, Silvia Gleitze, Jorge Toledo, Steffen Härtel, Cecilia Hidalgo, Andrea Paula-Lima

Publikováno v: Antioxidants, Vol 12, Iss 11, p 1972 (2023)

Hippocampal neuronal activity generates dendritic and somatic Ca2+ signals, which, depending on stimulus intensity, rapidly propagate to the nucleus and induce the expression of transcription factors and genes with crucial roles in cognitive function

Externí odkaz: https://doaj.org/article/88a0ccc9eab9414d995c1efde9f9eb0d

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Akademický článek

Reflectance confocal microscopy of spiradenoma

Autor: Pedro Lobos, MD, Constanza Lobos, MD, Karol Baksai, MD

Publikováno v: JAAD Case Reports, Vol 24, Iss , Pp 105-107 (2022)

Externí odkaz: https://doaj.org/article/f666ad4be3214b50bb792a8fa3ce46d6

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Akademický článek

Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition

Autor: Silvia Gleitze, Omar A. Ramírez, Ignacio Vega-Vásquez, Jing Yan, Pedro Lobos, Hilmar Bading, Marco T. Núñez, Andrea Paula-Lima, Cecilia Hidalgo

Publikováno v: Antioxidants, Vol 12, Iss 3, p 705 (2023)

Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione perox

Externí odkaz: https://doaj.org/article/7e44a1aca8de4abd84363887a9a07e2c

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Akademický článek

Immune thrombocytopenic purpura associated with coronavirus disease 2019 infection in an asymptomatic young healthy patient.

Autor: Pedro Lobos, MD, Constanza Lobos, MD, Paola Aravena, MD

Publikováno v: JAAD Case Reports, Vol 6, Iss 11, Pp 1129-1131 (2020)

Externí odkaz: https://doaj.org/article/53bcaa44aff54a89b944d2e6249f2f90

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Akademický článek

Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation

Autor: Francisca García, Pedro Lobos, Alejandra Ponce, Karla Cataldo, Daniela Meza, Patricio Farías, Carolina Estay, Felipe Oyarzun-Ampuero, Rodrigo Herrera-Molina, Andrea Paula-Lima, Álvaro O. Ardiles, Cecilia Hidalgo, Tatiana Adasme, Pablo Muñoz

Publikováno v: Marine Drugs, Vol 18, Iss 6, p 335 (2020)

Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen specie

Externí odkaz: https://doaj.org/article/c5063f1f59fd4d28ae07eeb71284f2cf

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Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform

Autor: Ignacio Vega-Vásquez, Pedro Lobos, Jorge Toledo, Tatiana Adasme, Andrea Paula-Lima, Cecilia Hidalgo

Publikováno v: Biochemical and biophysical research communications. 633

The hippocampus is a brain region implicated in synaptic plasticity and memory formation; both processes require neuronal Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231c18230a5b8a15932165b6afbdda38
https://pubmed.ncbi.nlm.nih.gov/36344175

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Akademický článek

RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

Autor: Cecilia Hidalgo, Andrea C. Paula-Lima, Carol D. SanMartín, Pablo Veloso, Tatiana Adasme, Pedro Lobos, Barbara Bruna, Jose Galaz, Alejandra García, Steffen Hartel

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low magnitude Ca2+ signals in neurons. We reported previously that these Ca2+ signals, which arise from Ca2+ entry and subseque

Externí odkaz: https://doaj.org/article/59437070bb3f4eae9f44742532a49741

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Akademický článek

Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers

Autor: Pedro Lobos, Barbara Bruna, Alex Cordova, Pablo Barattini, Jose Luis Galáz, Tatiana Adasme, Cecilia Hidalgo, Pablo Muñoz, Andrea Paula-Lima

Publikováno v: Neural Plasticity, Vol 2016 (2016)

Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer’s disease pathology. We reported previously that amyloid-β peptide oligomers (AβOs) produce aberrant Ca2+ signals at sublethal concentrati

Externí odkaz: https://doaj.org/article/afac18c5045a4f49b04c3054e031acb0

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