Zobrazeno 1 - 10
of 390
pro vyhledávání: '"Pedro, Cabrales"'
Autor:
Cynthia R. Muller, Alexander T. Williams, Allyn M. Eaker, Cynthia Walser, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116789- (2024)
The widespread adoption of high-calorie, high-fat, high-sucrose diets (HFHSD) has become a global health concern, particularly due to their association with cardiovascular diseases and metabolic disorders. These comorbidities increase susceptibility
Externí odkaz:
https://doaj.org/article/b20cb5ee5fce46bfbb87368a929784a2
Autor:
Carlos J. Munoz, Daniela Lucas, Jacinda Martinez, Mia Ricario, Quintin T. O'Boyle, Ivan S. Pires, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116569- (2024)
Alpha-alpha diaspirin-crosslinked human hemoglobin (DCLHb or ααHb) was a promising early generation red blood cell (RBC) substitute. The DCLHb was developed through a collaborative effort between the United States Army and Baxter Healthcare. The co
Externí odkaz:
https://doaj.org/article/56fb0c0c15a04929bbd507e481d79631
Autor:
Bryan Oronsky, Erica Burbano, Meaghan Stirn, Joanne Brechlin, Nacer Abrouk, Scott Caroen, Angelique Coyle, Jeannie Williams, Pedro Cabrales, Tony R. Reid
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1497-1509 (2023)
Abstract In drug development a frequently used phrase is “data‐driven”. Just as high‐test gas fuels a car, so drug development “runs on” high‐quality data; hence, good data management practices, which involve case report form design, da
Externí odkaz:
https://doaj.org/article/70093a437cb04467ae0f11efeab45dfb
Autor:
Cynthia R. Muller, Alexander T. Williams, Cynthia Walser, Allyn M. Eaker, Jose Luis Sandoval, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract For the past thirty years, hemoglobin-based oxygen carriers (HBOCs) have been under development as a red blood cell substitute. Side-effects such as vasoconstriction, oxidative injury, and cardiac toxicity have prevented clinical approval of
Externí odkaz:
https://doaj.org/article/7392dcbf710e404e92a253d0ccde2b43
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
RRx-001 is a shape shifting small molecule with Fast Track designation for the prevention/amelioration of chemoradiation-induced severe oral mucositis (SOM) in newly diagnosed Head and Neck cancer. It has been intentionally developed or “engineered
Externí odkaz:
https://doaj.org/article/948b4d29e3ef402ea3d3c221b0d0131e
Autor:
Tony Reid, Bryan Oronsky, Scott Caroen, Mary Quinn, Jeannie Williams, Pedro Cabrales, Nacer Abrouk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundBromonitrozidine (RRx-001) is a minimally toxic, NLRP3 inhibitor that has been observed, in experimental systems, to also downregulate CD47, repolarize tumor associated macrophages (TAMs) and normalize aberrant tumor perfusion. This phase 1
Externí odkaz:
https://doaj.org/article/6bc48b56408349eb8cecef4adf30d433
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113911- (2022)
β-thalassemia is a genetic hemoglobin (Hb) disorder that affects millions of people world-wide. It is characterized by ineffective erythropoiesis and anemia. The resultant chronic anemia can require life-long blood transfusion regimens, leading to s
Externí odkaz:
https://doaj.org/article/de54c08cc9264bf6be40b1ef68b4eed6
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10382 (2023)
Their widespread presence throughout the vasculature, coupled with their reactivity, and thereby to their potential to release reactive oxidative species, or to utilize their anti-oxidative capacities, has promoted much discussion of the role(s) of r
Externí odkaz:
https://doaj.org/article/88e7fecb9f8e418a8daf5f95167b812e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Fluid resuscitation following severe inflammation-induced hypoperfusion is critical for the restoration of hemodynamics and the prevention of multiorgan dysfunction syndrome during septic shock. Fluid resuscitation with commercially availabl
Externí odkaz:
https://doaj.org/article/c975693a2e82403babdaba58ccc0bc55
Autor:
Cynthia R. Muller, Vasiliki Courelli, Alfredo Lucas, Alexander T. Williams, Joyce B. Li, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Moses, Andre F. Palmer, Erik B. Kistler, Pedro Cabrales
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock (HS) after TBI is particularly challenging because the two therapeutic treatment strategies for TBI and HS often conflict. Ischemia/reperfusi
Externí odkaz:
https://doaj.org/article/498e933377124b19800d64b418baa677