A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma.

Autor: Pozniak J; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium. Electronic address: joanna.pozniak@kuleuven.be., Pedri D; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Laboratory for Membrane Trafficking, Center for Brain and Disease Research, VIB, Leuven, Belgium., Landeloos E; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven, Belgium., Van Herck Y; Department of General Medical Oncology, UZ Leuven, Leuven, Belgium., Antoranz A; Laboratory of Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven and UZ Leuven, Leuven, Belgium., Vanwynsberghe L; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Nowosad A; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Roda N; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Makhzami S; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Bervoets G; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Maciel LF; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Pulido-Vicuña CA; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Pollaris L; Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Seurinck R; Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Zhao F; Laboratory of Molecular Tumor Immunology, Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site Essen, Essen, Germany., Flem-Karlsen K; Department of Dermatology, Yale University, 15 York Street, New Haven, CT 05610, USA., Damsky W; Departments of Dermatology and Pathology, Yale University, 15 York Street, New Haven, CT 05610, USA., Chen L; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Karagianni D; Immune Regulation and Tumor Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, UCL Cancer Institute, London WC1E 6DD, UK., Cinque S; Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Kint S; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Vandereyken K; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Rombaut B; Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Voet T; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Vernaillen F; Bioinformatics Core, VIB, Ghent, Belgium., Annaert W; Laboratory for Membrane Trafficking, Center for Brain and Disease Research, VIB, Leuven, Belgium., Lambrechts D; Laboratory of Translational Genetics, Center for Cancer Biology, VIB, Leuven, Belgium; Center for Human Genetics, KU Leuven, Leuven, Belgium., Boecxstaens V; Department of Surgical Oncology, UZ Leuven, Leuven, Belgium., Saeys Y; Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., van den Oord J; Laboratory of Translational Cell and Tissue Research, Department of Pathology, UZ Leuven, Leuven, Belgium., Bosisio F; Laboratory of Translational Cell and Tissue Research, Department of Pathology, UZ Leuven, Leuven, Belgium., Karras P; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium., Shain AH; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Bosenberg M; Departments of Dermatology, Pathology and Immunobiology, Yale University, New Haven, CT 05610, USA., Leucci E; Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Paschen A; Laboratory of Molecular Tumor Immunology, Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), Partner Site Essen, Essen, Germany., Rambow F; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, Germany; University Duisburg-Essen, Essen, Germany. Electronic address: florian.rambow@uk-essen.de., Bechter O; Department of General Medical Oncology, UZ Leuven, Leuven, Belgium. Electronic address: oliver.bechter@uzleuven.be., Marine JC; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium. Electronic address: jeanchristophe.marine@kuleuven.be.

Publikováno v: Cell [Cell] 2024 Jan 04; Vol. 187 (1), pp. 166-183.e25.

A cellular hierarchy in melanoma uncouples growth and metastasis.

Autor: Karras P; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Bordeu I; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.; The Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.; Departamento de Física, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile., Pozniak J; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Nowosad A; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Pazzi C; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Van Raemdonck N; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Landeloos E; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Van Herck Y; Department of General Medical Oncology, UZ Leuven, Leuven, Belgium., Pedri D; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Bervoets G; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Makhzami S; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Khoo JH; BGI-Shenzhen, Shenzhen, China., Pavie B; VIB BioImaging Core, VIB Center for Brain and Disease Research, Leuven, Belgium.; VIB Bioimaging Core, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Lamote J; FACS Expertise Center, Center for Cancer Biology, VIB, Leuven, Belgium., Marin-Bejar O; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Dewaele M; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Liang H; BGI-Shenzhen, Shenzhen, China., Zhang X; BGI-Shenzhen, Shenzhen, China., Hua Y; Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory of Tumor Microenvironment and Therapeutic Resistance, Center for Cancer Biology, VIB, Leuven, Belgium., Wouters J; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Browaeys R; Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Bergers G; Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory of Tumor Microenvironment and Therapeutic Resistance, Center for Cancer Biology, VIB, Leuven, Belgium., Saeys Y; Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Bosisio F; Laboratory for Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., van den Oord J; Laboratory for Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Lambrechts D; Laboratory of Translational Genetics, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Translational Genetics, Center for Human Genetics, KU Leuven, Leuven, Belgium., Rustgi AK; Herbert Irving Comprehensive Center, Columbia University Irving Medical Center, New York, USA., Bechter O; Department of General Medical Oncology, UZ Leuven, Leuven, Belgium., Blanpain C; Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium., Simons BD; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.; The Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Cambridge, UK., Rambow F; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium. florian.rambow@kuleuven.vib.be.; Department of Oncology, KU Leuven, Leuven, Belgium. florian.rambow@kuleuven.vib.be.; Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, Germany. florian.rambow@kuleuven.vib.be.; University Duisburg-Essen, Essen, Germany. florian.rambow@kuleuven.vib.be.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany. florian.rambow@kuleuven.vib.be., Marine JC; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium. jeanchristophe.marine@kuleuven.vib.be.; Department of Oncology, KU Leuven, Leuven, Belgium. jeanchristophe.marine@kuleuven.vib.be.

Publikováno v: Nature [Nature] 2022 Oct; Vol. 610 (7930), pp. 190-198. Date of Electronic Publication: 2022 Sep 21.

248 A developmental cellular hierarchy in melanoma uncouples growth and metastatic phenotypes

Autor: Karras, P., Bordeu, I., Pozniak, J., Pazzi, C., Pedri, D., Landeloos, E., Van Raemdonck, N., van Herck, Y., Bosisio, F., Bechter, O., Blanpain, C., Simons, B., Rambow, F., Marine, J.

Publikováno v: In Journal of Investigative Dermatology October 2021 141(10) Supplement:S191-S191

Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies.

Autor: Zhu, Chang^1,2 (AUTHOR), Liao, Jing-Yu^1,2 (AUTHOR), Liu, Yi-Yang^1,2 (AUTHOR), Chen, Ze-Yu^1,2 (AUTHOR), Chang, Rui-Zhi^1,2 (AUTHOR), Chen, Xiao-Ping^1,2 (AUTHOR), Zhang, Bi-Xiang^1,2 (AUTHOR) bixiangzhang@hust.edu.cn, Liang, Jun-Nan^1,2 (AUTHOR) liangjunnan@tjh.tjmu.edu.cn

Publikováno v: Molecular Cancer. 11/14/2024, Vol. 23 Issue 1, p1-25. 25p.

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma.

Autor: Wouters J; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Kalender-Atak Z; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Minnoye L; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Spanier KI; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., De Waegeneer M; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Bravo González-Blas C; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Mauduit D; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Davie K; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Hulselmans G; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Najem A; Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Dewaele M; Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Pedri D; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Neurosciences, KU Leuven, Leuven, Belgium., Rambow F; Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Makhzami S; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Christiaens V; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Ceyssens F; ESAT-MICAS, KU Leuven, Leuven, Belgium., Ghanem G; Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Marine JC; Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Poovathingal S; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium., Aerts S; Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium. stein.aerts@kuleuven.vib.be.; Department of Human Genetics, KU Leuven, Leuven, Belgium. stein.aerts@kuleuven.vib.be.

Publikováno v: Nature cell biology [Nat Cell Biol] 2020 Aug; Vol. 22 (8), pp. 986-998. Date of Electronic Publication: 2020 Aug 03.