Emerging and Future Targeted Therapies for Pediatric Acute Myeloid Leukemia: Targeting the Leukemia Stem Cells

Autor: Lindsey A. Murphy, Amanda C. Winters

Publikováno v: Biomedicines, Vol 11, Iss 12, p 3248 (2023)

Acute myeloid leukemia (AML) is a rare subtype of acute leukemia in the pediatric and adolescent population but causes disproportionate morbidity and mortality in this age group. Standard chemotherapeutic regimens for AML have changed very little in

Externí odkaz: https://doaj.org/article/8ea1843eaf054dd08613de185b4b329e

Molecular-Targeted Therapy of Pediatric Acute Myeloid Leukemia

Autor: Piotr Obszański, Anna Kozłowska, Jakub Wańcowiat, Julia Twardowska, Monika Lejman, Joanna Zawitkowska

Publikováno v: Molecules, Vol 27, Iss 12, p 3911 (2022)

Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood leukemia cases. The overall survival of children with acute myeloid leukemia does not exceed 82%, and the 5-year event-free survival rates range from 46% to 69%. Such s

Externí odkaz: https://doaj.org/article/422f4be5ea1443609dae7c185f2fb584

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Corrigendum: Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention

Autor: Thomas Mercher, Juerg Schwaller

Publikováno v: Frontiers in Pediatrics, Vol 7 (2019)

Externí odkaz: https://doaj.org/article/0b9dc6742a4d4c1dbdb85527b5ad424c

Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells

Autor: Inge van der Werf, Phoebe K. Mondala, S. Kathleen Steel, Larisa Balaian, Luisa Ladel, Cayla N. Mason, Raymond H. Diep, Jessica Pham, Jacqueline Cloos, Gertjan J.L. Kaspers, Warren C. Chan, Adam Mark, James J. La Clair, Peggy Wentworth, Kathleen M. Fisch, Leslie A. Crews, Thomas C. Whisenant, Michael D. Burkart, Mary E. Donohoe, Catriona H.M. Jamieson

Publikováno v: Cell reports. Medicine, vol 4, iss 3
Cell reports. Medicine, 4(3):100962. Cell Press
Cell Reports Medicine, 4(3):100962. Cell Press
van der Werf, I, Mondala, P K, Steel, S K, Balaian, L, Ladel, L, Mason, C N, Diep, R H, Pham, J, Cloos, J, Kaspers, G J L, Chan, W C, Mark, A, la Clair, J J, Wentworth, P, Fisch, K M, Crews, L A, Whisenant, T C, Burkart, M D, Donohoe, M E & Jamieson, C H M 2023, ' Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells ', Cell reports. Medicine, vol. 4, no. 3, 100962, pp. 100962 . https://doi.org/10.1016/j.xcrm.2023.100962, https://doi.org/10.1016/j.xcrm.2023.100962

Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635fc2f87ba6c7bb45c6b2245e0c70ae
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