Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Peder J. Lund"'
Autor:
Siddhant U. Jain, Truman J. Do, Peder J. Lund, Andrew Q. Rashoff, Katharine L. Diehl, Marcin Cieslik, Andrea Bajic, Nikoleta Juretic, Shriya Deshmukh, Sriram Venneti, Tom W. Muir, Benjamin A. Garcia, Nada Jabado, Peter W. Lewis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
PFA tumours express high levels of EZHIP (also known as CXORF67). Here the authors find that EZHIP directly interacts with the active site of EZH2 and is a competitive inhibitor of PRC2 and that EZHIP gives rise to H3K27me3 genomic profile similar to
Externí odkaz:
https://doaj.org/article/7a64b34bead04eeeabaa7ea08c232938
Autor:
Nora Yucel, Yu Xin Wang, Thach Mai, Ermelinda Porpiglia, Peder J. Lund, Glenn Markov, Benjamin A. Garcia, Sean C. Bendall, Michael Angelo, Helen M. Blau
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3939-3955.e6 (2019)
Summary: The impact of glucose metabolism on muscle regeneration remains unresolved. We identify glucose metabolism as a crucial driver of histone acetylation and myogenic cell fate. We use single-cell mass cytometry (CyTOF) and flow cytometry to cha
Externí odkaz:
https://doaj.org/article/a6a7fe8b0fb044af811f41a7b1931889
Autor:
Leah A. Gates, Bernardo Sgarbi Reis, Peder J. Lund, Matthew R. Paul, Marylene Leboeuf, Zara Nadeem, Tom S. Carroll, Benjamin A. Garcia, Daniel Mucida, C. David Allis
SUMMARYPosttranslational modifications (PTMs) on histone proteins are a key source of regulation on chromatin through impacting genome organization and important cellular processes, including gene expression. These PTMs often arise from small metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f771098e749840d4690b8e3ee171a8b1
https://doi.org/10.1101/2022.09.29.510184
https://doi.org/10.1101/2022.09.29.510184
Autor:
Matteo Trovato, Simone Sidoli, Benjamin A. Garcia, Yekaterina Kori, Zuo-Fei Yuan, Kyung-Min Noh, Peder J. Lund
Publikováno v:
Mol Omics
Histone variants, such as histone H3.3, replace canonical histones within the nucleosome to alter chromatin accessibility and gene expression. Although the biological roles of selected histone post-translational modifications (PTMs) have been extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a291dc33cf7c2725f1217faf3df483
https://europepmc.org/articles/PMC9098674/
https://europepmc.org/articles/PMC9098674/
Autor:
Sima Khazaei, Carol C.L. Chen, Augusto Faria Andrade, Nisha Kabir, Pariya Azarafshar, Shahir M. Morcos, Josiane Alves França, Mariana Lopes, Peder J. Lund, Geoffroy Danieau, Samantha Worme, Lata Adnani, Nadine Nzirorera, Xiao Chen, Gayathri Yogarajah, Caterina Russo, Michele Zeinieh, Cassandra J. Wong, Laura Bryant, Steven Hébert, Bethany Tong, Tianna S. Sihota, Damien Faury, Evan Puligandla, Wajih Jawhar, Veronica Sandy, Mitra Cowan, Emily M. Nakada, Loydie A. Jerome-Majewska, Benjamin Ellezam, Carolina Cavalieri Gomes, Jonas Denecke, Davor Lessel, Marie T. McDonald, Carolyn E. Pizoli, Kathryn Taylor, Benjamin T. Cocanougher, Elizabeth J. Bhoj, Anne-Claude Gingras, Benjamin A. Garcia, Chao Lu, Eric I. Campos, Claudia L. Kleinman, Livia Garzia, Nada Jabado
Publikováno v:
Cell. 186:1162-1178.e20
Autor:
Shelly C. Lu, Vidya Venkatraman, George Rosenberger, Gautam Saxena, Aleksandra Binek, Brian C. Searle, Nathan Basisty, Birgit Schilling, Ronald J. Holewinski, Jennifer E. Van Eyk, Benjamin A. Garcia, Peder J. Lund, Aaron E. Robinson, Xueshu Xie, Sarah J. Parker, José M. Mato
Publikováno v:
Journal of Proteome Research. 19:4163-4178
Proteoforms containing post-translational modifications (PTMs) represent a degree of functional diversity only harnessed through analytically precise simultaneous quantification of multiple PTMs. Here we present a method to accurately differentiate a
Autor:
Elliot S. Friedman, Patricia A. DeRusso, Yuan Tian, Anumita Saha-Shah, Michal A. Elovitz, Josephine Ni, Andrea Kelly, Jingwei Cai, Debolina Sarkar, Lisa M. Mattei, Gary D. Wu, Mark Goulian, Casey E. Hofstaedter, Benjamin A. Garcia, Chunyu Zhao, Frederic D. Bushman, Eileen G Ford, Kyle Bittinger, Qing Liu, Chiraag Kulkarni, Peder J. Lund, Costas D. Maranas, Jeffrey S. Gerber, Dorothy Kim, Hongzhe Li, Siu Hung Joshua Chan, Andrew D. Patterson, Yun Li, Babette S. Zemel
Publikováno v:
Nature microbiology
Initial microbial colonization and later succession in the gut of human infants are linked to health and disease later in life. The timing of the appearance of the first gut microbiome, and the consequences for the early life metabolome, are just sta
Autor:
Simone Sidoli, Mariel Coradin, Congcong Lu, Charles W. M. Robert, Zhexin Zhu, Elizabeth G. Porter, Peder J. Lund, Benjamin A. Garcia, Joseph Cesare, Yekaterina Kori, Yemin Lan
Histone proteolysis is a poorly understood phenomenon in which the N-terminal tails of histones are irreversibly cleaved by intracellular proteases. During development, histone post-translational modifications are known to orchestrate gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9956f872c44aac72cb0cf8d1fb510d
https://doi.org/10.1101/2021.08.10.455684
https://doi.org/10.1101/2021.08.10.455684
Autor:
Lillian Chau, Emma E. Furth, Ting-Chin David Shen, Shivali Patel, Gary D. Wu, Sunhee Jung, Peder J. Lund, Elliot S. Friedman, Cholsoon Jang, Benjamin A. Garcia, Victoria M. Gershuni, Yedidya Saiman
Publikováno v:
Hepatology
Hepatology (Baltimore, Md.), vol 74, iss 6
Hepatology (Baltimore, Md.), vol 74, iss 6
Background and aims Although germ-free mice are an indispensable tool in studying the gut microbiome and its effects on host physiology, they are phenotypically different than their conventional counterparts. While antibiotic-mediated microbiota depl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d51529b3e6c0e152b3e99469c983a3a
https://europepmc.org/articles/PMC9867598/
https://europepmc.org/articles/PMC9867598/
Autor:
Peder J. Lund, Leah A. Gates, Marylene Leboeuf, Sarah A. Smith, Lillian Chau, Mariana Lopes, Elliot S. Friedman, Yedidya Saiman, Min Soo Kim, Clarissa A. Shoffler, Christopher Petucci, C. David Allis, Gary D. Wu, Benjamin A. Garcia
Publikováno v:
Cell Rep
The gut microbiota influences acetylation on host histones by fermenting dietary fiber into butyrate. Although butyrate could promote histone acetylation by inhibiting histone deacetylases, it may also undergo oxidation to acetyl-coenzyme A (CoA), a