Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Autor: Temprano‐Sagrera, Gerard, Sitlani, Colleen M., Bone, William P., Martin‐Bornez, Miguel, Voight, Benjamin F., Morrison, Alanna C., Damrauer, Scott M., de Vries, Paul S., Smith, Nicholas L., Sabater‐Lleal, Maria ^*, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank W.G., Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L, Peyser, Patricia A, Elliot, Paul, de Vries, Paul S, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean‐François, O’Donnell, Chris J, Kim, Jihye, Kraft, Peter, Hansen, John‐Bjarne, Heit, John A, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre‐Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David‐Alexandre, Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten‐Jacobs, Loes, Giese, Anne‐Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chen, Wei‐Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Holliday, Elizabeth G, Howard, George, Hsu, Fang‐Chi, Hyacinth, Hyacinth I, Arfan Ikram, M, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez‐Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin‐Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei‐Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Pulit, Sara L, Rannikmäe, Kristiina, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Rost, Natalia S, Rothwell, Peter M, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil‐Smoller, Sylvia, Wilson, James G, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu‐Ching, Hoan Choi, Seung, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean‐François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Mei Liu, Yong, Lopez, Oscar L, Makoto, Hirata, Martinez‐Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller‐Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Reddy Peddareddygari, Leema, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba‐Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti‐Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano‐Tárraga, Carolina, Stanne, Tara, Colin Stine, O, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres‐Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez‐Cadenas, Israel, Longstreth, W T, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, Dichgans, Martin

Publikováno v: In Journal of Thrombosis and Haemostasis June 2022 20(6):1331-1349

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

Autor: Pulit, Sara L, McArdle, Patrick F, Wong, Quenna, Malik, Rainer, Gwinn, Katrina, Achterberg, Sefanja, Algra, Ale, Amouyel, Philippe, Anderson, Christopher D, Arnett, Donna K, Arsava, Ethem Murat, Attia, John, Ay, Hakan, Bartz, Traci M, Battey, Thomas, Benavente, Oscar R, Bevan, Steve, Biffi, Alessandro, Bis, Joshua C, Blanton, Susan H, Boncoraglio, Giorgio B, Brown, Robert D, Jr, Burgess, Annette I, Carrera, Caty, Chapman Smith, Sherita N, Chasman, Daniel I, Chauhan, Ganesh, Chen, Wei-Min, Cheng, Yu-Ching, Chong, Michael, Cloonan, Lisa K, Cole, John W, Cotlarciuc, Ioana, Cruchaga, Carlos, Cuadrado-Godia, Elisa, Dave, Tushar, Dawson, Jesse, Debette, Stéphanie, Delavaran, Hossein, Dell, Cameron A, Dichgans, Martin, Doheny, Kimberly F, Dong, Chuanhui, Duggan, David J, Engström, Gunnar, Evans, Michele K, Pallejà, Xavier Estivill, Faul, Jessica D, Fernández-Cadenas, Israel, Fornage, Myriam, Frossard, Philippe M, Furie, Karen, Gamble, Dale M, Gieger, Christian, Giese, Anne-Katrin, Giralt-Steinhauer, Eva, González, Hector M, Goris, An, Gretarsdottir, Solveig, Grewal, Raji P, Grittner, Ulrike, Gustafsson, Stefan, Han, Buhm, Hankey, Graeme J, Heitsch, Laura, Higgins, Peter, Hochberg, Marc C, Holliday, Elizabeth, Hopewell, Jemma C, Horenstein, Richard B, Howard, George, Ikram, M Arfan, Ilinca, Andreea, Ingelsson, Erik, Irvin, Marguerite R, Jackson, Rebecca D, Jern, Christina, Conde, Jordi Jiménez, Johnson, Julie A, Jood, Katarina, Kahn, Muhammad S, Kaplan, Robert, Kappelle, L Jaap, Kardia, Sharon L R, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Koblar, Simon, Labovitz, Daniel, Launer, Lenore J, Laurie, Cathy C, Laurie, Cecelia A, Lee, Cue Hyunkyu, Lee, Jin-Moo, Lehm, Manuel, Lemmens, Robin, Levi, Christopher, Leys, Didier, Lindgren, Arne, Longstreth, W T, Jr, Maguire, Jane, Manichaikul, Ani, Markus, Hugh S, McClure, Leslie A, McDonough, Caitrin W, Meisinger, Christa, Melander, Olle, Meschia, James F, Mola-Caminal, Marina, Montaner, Joan, Mosley, Thomas H, Müller-Nurasyid, Martina, Nalls, Mike A, O'Connell, Jeffrey R, O'Donnell, Martin, Ois, ángel, Papanicolaou, George J, Paré, Guillaume, Peddareddygari, Leema Reddy, Pedersén, Annie, Pera, Joanna, Peters, Annette, Poole, Deborah, Psaty, Bruce M, Rabionet, Raquel, Raffeld, Miriam R, Rannikmäe, Kristiina, Rasheed, Asif, Redfors, Petra, Reiner, Alex P, Rexrode, Kathryn, Ribasés, Marta, Rich, Stephen S, Robberecht, Wim, Rodriguez-Campello, Ana, Rolfs, Arndt, Roquer, Jaume, Rose, Lynda M, Rosenbaum, Daniel, Rost, Natalia S, Rothwell, Peter M, Rundek, Tatjana, Ryan, Kathleen A, Sacco, Ralph L, Sale, Michèle M, Saleheen, Danish, Salomaa, Veikko, Sánchez-Mora, Cristina, Schmidt, Carsten Oliver, Schmidt, Helena, Schmidt, Reinhold, Schürks, Markus, Scott, Rodney, Segal, Helen C, Seiler, Stephan, Seshadri, Sudha, Sharma, Pankaj, Shuldiner, Alan R, Silver, Brian, Slowik, Agnieszka, Smith, Jennifer A, Söderholm, Martin, Soriano, Carolina, Sparks, Mary J, Stanne, Tara, Stefansson, Kari, Stine, O Colin, Strauch, Konstantin, Sturm, Jonathan, Sudlow, Cathie LM, Tajuddin, Salman M, Talbert, Robert L, Tatlisumak, Turgut, Thijs, Vincent, Thorleifsson, Gudmar, Thorsteindottir, Unnur, Tiedt, Steffen, Traylor, Matthew, Trompet, Stella, Valant, Valerie, Waldenberger, Melanie, Walters, Matthew, Wang, Liyong, Wassertheil-Smoller, Sylvia, Weir, David R, Wiggins, Kerri L, Williams, Stephen R, Wloch-Kopec, Dorota, Woo, Daniel, Woodfield, Rebecca, Wu, Ona, Xu, Huichun, Zonderman, Alan B, Worrall, Bradford B, de Bakker, Paul IW, Kittner, Steven J, Mitchell, Braxton D, Rosand, Jonathan, Sudlow, Cathie L M, Worrall, Bradford B Worrall, Arnett, Donna K Arnett, Benavente, Oscar, Wasssertheil-Smoller, Sylvia

Publikováno v: In The Lancet Neurology February 2016 15(2):174-184

Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke

Autor: Jaworek, Thomas, Xu, Huichun, Attia, John, Veldink, Jan H, Walters, Robin G, Weir, David R, Woo, Daniel, Worrall, Bradford B, Hong, Charles C, Ross, Owen, Zand, Ramin, Leeuw, Frank-Erik de, Lindgren, Arne G, Bell, Steven, Pare, Guillaume, Anderson, Christopher D, Markus, Hugh S, Jern, Christina, Malik, Rainer, Dichgans, Martin, Mitchell, Braxton D, Kittner, Steven J, Consortium, Early Onset Stroke Genetics Consortium of the International Stroke Genetics, Benavente, Oscar R, Boncoraglio, Giorgio B, Butterworth, Adam, Dissections, Cervical Artery, Patients, Ischemic Stroke, Carcel-Marquez, Jara, Chen, Zhengming, Chong, Michael, Gaynor, Brady J, Cruchaga, Carlos, Cushman, Mary, Danesh, John, Debette, Stephanie, Duggan, David J, Durda, Jon Peter, Engstrom, Gunnar, Enzinger, Chris, Faul, Jessica D, Fecteau, Natalie S, Cole, John W, Fernandez-Cadenas, Israel, Gieger, Christian, Giese, Anne-Katrin, Grewal, Raji P, Grittner, Ulrike, Havulinna, Aki S, Heitsch, Laura, Hochberg, Marc C, Holliday, Elizabeth, Hu, Jie, Rannikmae, Kristiina, Ilinca, Andreea, Consortium, INVENT, Irvin, Marguerite R, Jackson, Rebecca D, Jacob, Mina A, Janssen, Raquel Rabionet, Jimenez-Conde, Jordi, Johnson, Julie A, Kamatani, Yoichiro, Kardia, Sharon L, Stanne, Tara M, Koido, Masaru, Kubo, Michiaki, Lange, Leslie, Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher R, Li, Jiang, Li, Liming, Lin, Kuang, Lopez, Haley, Tomppo, Liisa, Luke, Sothear, Maguire, Jane, McArdle, Patrick F, McDonough, Caitrin W, Meschia, James F, Metso, Tiina, Muller-Nurasyid, Martina, O'Connor, Timothy D, O'Donnell, Martin, Peddareddygari, Leema R, Abedi, Vida, Pera, Joanna, Perry, James A, Peters, Annette, Putaala, Jukka, Ray, Debashree, Rexrode, Kathryn, Ribases, Marta, Rosand, Jonathan, Rothwell, Peter M, Rundek, Tatjana, Amouyel, Philippe, Ryan, Kathleen A, Sacco, Ralph L, Salomaa, Veikko, Sanchez-Mora, Cristina, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Smith, Jennifer A, Smith, Nicholas L, Wassertheil-Smoller, Sylvia, Armstrong, Nicole D, Soederholm, Martin, Stine, O. C., Strbian, Daniel, Sudlow, Cathie L, Tatlisumak, Turgut, Terao, Chikashi, Thijs, Vincent, Torres-Aguila, Nuria P, Tregouet, David-Alexandre, Tuladhar, Anil M

Publikováno v: Neurology 99(16), e1738-e1754 (2022). doi:10.1212/WNL.0000000000201006
Jaworek, T, Xu, H, Gaynor, B, Cole, J, Rannikmae, K, Stanne, T M, Tomppo, L, Abedi, V, Amouyel, P, Armstrong, N, Attia, J, Bell, S, Benavente, O R, Boncoraglio, G B, Butterworth, A S, Carcel-Marquez, J, Chen, Z, Chong, M, Cruchaga, C, Cushman, M, Danesh, J, Debette, S, Duggan, D, Durda, J P, Engstrom, G, Enzinger, C, Faul, J D, Fecteau, N, Fernandez-Cadenas, I, Gieger, C, Giese, A-K, Grewal, R P, Grittner, U, Havulinna, A S, Heitsch, L, Hochberg, M, Holliday, E G, Zhu, J, Llinca, A, Irvin, M R, Jackson, R D, Jacob, M, Rabionet-Janssen, R, Jimenez-Conde, J, Johnson, J A, Kamatani, Y, Kardia, S L R, Koido, M, Kubo, M, Lange, L A, Lee, J-M, Lemmens, R, Levi, C, Li, J, Lin, K, Lopez, H, Maguire, J M, Luke, S, McArdle, P F, McDonough, C W, Meschia, J, Metso, T M, Müller-Nurasyid, M, O'Connor, T, Peddareddygari, L R, O'Donnell, M, Pera, J, Perry, J, Peters, A, Putaala, J, Ray, D, Rexrode, K M, Ribases, M, Rosand, J, Rothwell, P M, Rundek, T, Ryan, K, Sacco, R L, Salomaa, V, Sánchez-Mora, C, Schmidt, R, Sharma, P, Slowik, A, Smith, J, Smith, N L, Wassertheil-Smoller, S, Söderholm, M, Stine, C, Strbian, D, Sudlow, C L M, Tatlisumak, T, Terao, C, Thijs, V, Torres-Aguila, N, Tregouet, D-A, Tuladhar, A M, Veldink, J H, Walters, R G, Weir, D R, Woo, D, Worrall, B B, Hong, C, Ross, O A, Zand, R, de Leeuw, F-E, Lindgren, A, Pare, G, Anderson, C D, Markus, H S, Jern, C, Malik, R, Dichgans, M, Mitchell, B D & Kittner, S J 2022, ' Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke ', Neurology, vol. 99, no. 16, pp. e1738-e1754 . https://doi.org/10.1212/WNL.0000000000201006

Background and Objectives:Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early ons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f90257f92b8480b7d7d014740c0376c
https://lirias.kuleuven.be/handle/20.500.12942/716243

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A Novel Duplication Mutation in the Myelin Protein Zero Gene Causing Mild, Nonprogressive Demyelinating Neuropathy

Autor: Oberoi, Kinsi, Grewal, Alam S., Peddareddygari, Leema Reddy

Publikováno v: Case Reports in Neurology

Mutations in the myelin protein zero (MPZ) gene can cause a variety of clinical and electrophysiological forms of genetic neuropathies including Charcot-Marie-Tooth (CMT) type 1B disease which is characterized by demyelinating features. We present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbc00018b505ffe7b4aaaae39b8c21b7
http://europepmc.org/articles/PMC7443678