mRNA-encoded Cas13 can be used to treat dengue infections in mice.

Autor: Basu M; Department of Biology, Georgia State University, Atlanta, GA, USA., Zurla C; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Auroni TT; Department of Biology, Georgia State University, Atlanta, GA, USA., Vanover D; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Chaves LCS; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Sadhwani H; Department of Biology, Georgia State University, Atlanta, GA, USA., Pathak H; Department of Biology, Georgia State University, Atlanta, GA, USA., Basu R; Department of Biology, Georgia State University, Atlanta, GA, USA., Beyersdorf JP; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Amuda OO; Department of Biology, Georgia State University, Atlanta, GA, USA., Elsharkawy A; Department of Biology, Georgia State University, Atlanta, GA, USA., Mosur V; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Arthur RA; Emory Integrated Computational Core, Emory University, Atlanta, GA, USA., Claussen H; Emory Integrated Computational Core, Emory University, Atlanta, GA, USA., Sasser LE; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Wroe JA; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Peck HE; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA., Kumar M; Department of Biology, Georgia State University, Atlanta, GA, USA. mkumar8@gsu.edu., Brinton MA; Department of Biology, Georgia State University, Atlanta, GA, USA. mbrinton@gsu.edu., Santangelo PJ; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA. philip.j.santangelo@emory.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Aug; Vol. 9 (8), pp. 2160-2172. Date of Electronic Publication: 2024 Jun 05.

Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.

Autor: Radmand A; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332.; Department of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA 30332., Kim H; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Beyersdorf J; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Dobrowolski CN; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Zenhausern R; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Paunovska K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Huayamares SG; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Hua X; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Han K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Loughrey D; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Hatit MZC; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Del Cid A; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Ni H; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Shajii A; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Li A; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Muralidharan A; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332.; Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332., Peck HE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Tiegreen KE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Jia S; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Santangelo PJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332., Dahlman JE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 12; Vol. 121 (11), pp. e2307801120. Date of Electronic Publication: 2024 Mar 04.

Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung.

Autor: Rotolo L; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Vanover D; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Bruno NC; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA., Peck HE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Zurla C; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Murray J; Department of Infectious Diseases, College of Veterinary Medicine University of Georgia, Athens, GA, USA., Noel RK; Physiological Research Laboratory, Georgia Institute of Technology, Atlanta, GA, USA., O'Farrell L; Physiological Research Laboratory, Georgia Institute of Technology, Atlanta, GA, USA., Araínga M; New Iberia Research Center, University of Louisiana Lafayette, Lafayette, LA, USA., Orr-Burks N; Department of Infectious Diseases, College of Veterinary Medicine University of Georgia, Athens, GA, USA., Joo JY; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Chaves LCS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Jung Y; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Beyersdorf J; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Gumber S; Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA., Guerrero-Ferreira R; Robert P. Apkarian Integrated Electron Microscopy Core, Emory University, Atlanta, GA, USA., Cornejo S; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA., Thoresen M; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA., Olivier AK; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA., Kuo KM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA., Gumbart JC; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.; School of Physics, Georgia Institute of Technology, Atlanta, GA, USA., Woolums AR; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA., Villinger F; New Iberia Research Center, University of Louisiana Lafayette, Lafayette, LA, USA., Lafontaine ER; Department of Infectious Diseases, College of Veterinary Medicine University of Georgia, Athens, GA, USA., Hogan RJ; Department of Infectious Diseases, College of Veterinary Medicine University of Georgia, Athens, GA, USA.; Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine University of Georgia, Athens, GA, USA., Finn MG; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Santangelo PJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. philip.j.santangelo@emory.edu.

Publikováno v: Nature materials [Nat Mater] 2023 Mar; Vol. 22 (3), pp. 369-379. Date of Electronic Publication: 2022 Nov 28.

Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.

Autor: Ni H; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Hatit MZC; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Zhao K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.; School of Pharmaceutical Sciences, Shandong University, Jinan, China., Loughrey D; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Lokugamage MP; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Peck HE; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA., Cid AD; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Muralidharan A; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.; Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA, USA., Kim Y; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.; Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA, USA., Santangelo PJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Dahlman JE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. james.dahlman@bme.gatech.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Aug 15; Vol. 13 (1), pp. 4766. Date of Electronic Publication: 2022 Aug 15.

Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators.

Autor: Beyersdorf JP; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Krone Engineering Biosystems Building, 950 Atlantic Drive NW, Atlanta, Georgia 30332, United States., Bawage S; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Krone Engineering Biosystems Building, 950 Atlantic Drive NW, Atlanta, Georgia 30332, United States., Iglesias N; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States., Peck HE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Krone Engineering Biosystems Building, 950 Atlantic Drive NW, Atlanta, Georgia 30332, United States., Hobbs RA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Krone Engineering Biosystems Building, 950 Atlantic Drive NW, Atlanta, Georgia 30332, United States., Wroe JA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Krone Engineering Biosystems Building, 950 Atlantic Drive NW, Atlanta, Georgia 30332, United States., Zurla C; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Krone Engineering Biosystems Building, 950 Atlantic Drive NW, Atlanta, Georgia 30332, United States., Gersbach CA; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.; Center for Advanced Genomic Technologies, Duke University, Durham, North Carolina 27708, United States.; Department of Surgery, Duke University Medical Center, Durham, North Carolina 27708, United States., Santangelo PJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Krone Engineering Biosystems Building, 950 Atlantic Drive NW, Atlanta, Georgia 30332, United States.

Publikováno v: ACS nano [ACS Nano] 2022 Apr 26; Vol. 16 (4), pp. 5660-5671. Date of Electronic Publication: 2022 Mar 31.