Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

Autor: Terry D. Butters, Łukasz F. Sobala, Nicole Zitzmann, Andrew J. Thompson, Gideon J. Davies, Dominic S. Alonzi, Michelle L. Hill, Z. Hakki, Spencer J. Williams, Pearl Z. Fernandes, Zania Stamataki, Scott P Davies, J.D. Howe

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance The glycosylation of proteins is a major protein modification that occurs extensively in eukaryotes. Glycosidases in the secretory pathway that trim N-linked glycans play key roles in protein quality control and in the specific modificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b481226427dfdd41b6ee04c5f49d552
https://doi.org/10.1073/pnas.2013620117

Author Correction: A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation

Autor: Paul Dupree, Tiaan Heunis, Nicolas Terrapon, Alan Cartmell, Li Yu, Joe W. Gray, Bernard Henrissat, Elisabeth C. Lowe, Katherine Stott, Pearl Z. Fernandes, Jose Munoz-Munoz, Aurore Labourel, Harry J. Gilbert, Jonathon A. Briggs, Didier Ndeh, Arnaud Baslé, Matthias Trost, Sayali Shah, Spencer J. Williams

Publikováno v: Nature Microbiology. 4:2021-2023

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::783d2a33066f93f0a00386b47f28a459
https://doi.org/10.1038/s41564-019-0584-5

Contribution of shape and charge to the inhibition of a family GH99 endo-α-1,2-mannanase

Autor: Jesús Jiménez-Barbero, Sha Zhu, Lluís Raich, Lukasz F. Sobala, Matthieu Sollogoub, Carme Rovira, Ganeko Bernardo-Seisdedos, Andrew J. Thompson, Pearl Z. Fernandes, Gideon J. Davies, M. Petricevic, Spencer J. Williams, Oscar Millet

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2017, 139 (3), pp.1089--1097. ⟨10.1021/jacs.6b10075⟩
Journal of the American Chemical Society, 2017, 139 (3), pp.1089--1097. ⟨10.1021/jacs.6b10075⟩

Inhibitor design incorporating features of the reaction coordinate and transition-state structure has emerged as a powerful approach for the development of enzyme inhibitors. Such inhibitors find use as mechanistic probes, chemical biology tools, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008ab87065b439a46c4f8ab6c73f297d
https://eprints.whiterose.ac.uk/112128/1/accepted_pdf.pdf