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Akademický článek

Complement inhibition by Sarcoptes scabiei protects Streptococcus pyogenes - An in vitro study to unravel the molecular mechanisms behind the poorly understood predilection of S. pyogenes to infect mite-induced skin lesions.

Autor: Pearl M Swe, Lindsay D Christian, Hieng C Lu, Kadaba S Sriprakash, Katja Fischer

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005437 (2017)

BACKGROUND:On a global scale scabies is one of the most common dermatological conditions, imposing a considerable economic burden on individuals, communities and health systems. There is substantial epidemiological evidence that in tropical regions s

Externí odkaz: https://doaj.org/article/eb6c7047c68447a3a86a35daff8ff805

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Akademický článek

A scabies mite serpin interferes with complement-mediated neutrophil functions and promotes staphylococcal growth.

Autor: Pearl M Swe, Katja Fischer

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2928 (2014)

BACKGROUND: Scabies is a contagious skin disease caused by the parasitic mite Sarcoptes scabiei. The disease is highly prevalent worldwide and known to predispose to secondary bacterial infections, in particular by Streptococcus pyogenes and Staphylo

Externí odkaz: https://doaj.org/article/39a948409fab45dabd5e27dca382aaf1

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Akademický článek

Scabies mites alter the skin microbiome and promote growth of opportunistic pathogens in a porcine model.

Autor: Pearl M Swe, Martha Zakrzewski, Andrew Kelly, Lutz Krause, Katja Fischer

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2897 (2014)

BACKGROUND: The resident skin microbiota plays an important role in restricting pathogenic bacteria, thereby protecting the host. Scabies mites (Sarcoptes scabiei) are thought to promote bacterial infections by breaching the skin barrier and excretin

Externí odkaz: https://doaj.org/article/d5d8078b3afd4e7e9899c530621df142

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Akademický článek

Novel scabies mite serpins inhibit the three pathways of the human complement system.

Autor: Angela Mika, Simone L Reynolds, Frida C Mohlin, Charlene Willis, Pearl M Swe, Darren A Pickering, Vanja Halilovic, Lakshmi C Wijeyewickrema, Robert N Pike, Anna M Blom, David J Kemp, Katja Fischer

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40489 (2012)

Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade h

Externí odkaz: https://doaj.org/article/febdc3f5832d46f69ef210d1b47c34a3

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Akademický článek

First Description of the Composition and the Functional Capabilities of the Skin Microbial Community Accompanying Severe Scabies Infestation in Humans

Autor: Charlotte Bernigaud, Martha Zakrzewski, Sara Taylor, Pearl M. Swe, Anthony T. Papenfuss, Kadaba S. Sriprakash, Deborah Holt, Olivier Chosidow, Bart J. Currie, Katja Fischer

Publikováno v: Microorganisms, Vol 9, Iss 5, p 907 (2021)

Epidemiological studies link Sarcoptes scabiei infection and impetigo. Scabies mites can promote Streptococcus pyogenes (Group A Streptococcus) and Staphylococcus aureus infections by breaching the skin barrier and excreting molecules that inhibit ho

Externí odkaz: https://doaj.org/article/0ebe5073381b45378e36789dfd6981ed

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First Description of the Composition and the Functional Capabilities of the Skin Microbial Community Accompanying Severe Scabies Infestation in Humans

Autor: Pearl M. Swe, Martha Zakrzewski, Deborah C. Holt, Katja Fischer, Olivier Chosidow, Anthony T. Papenfuss, Sara Taylor, Charlotte Bernigaud, Kadaba S. Sriprakash, Bart J. Currie

Publikováno v: Microorganisms
Microorganisms, Vol 9, Iss 907, p 907 (2021)
Volume 9
Issue 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73d46a679748870d1f83117672be4e6
https://pubmed.ncbi.nlm.nih.gov/33922793

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High-throughput metagenome analysis of the Sarcoptes scabiei internal microbiota and in-situ identification of intestinal Streptomyces sp

Autor: Rebecca Waddell, Pearl M. Swe, Martha Zakrzewski, Katja Fischer, Kadaba S. Sriprakash

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58163abcc110ed88f205fdc94f70742
https://doi.org/10.1038/s41598-019-47892-0

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Autor: Lindsay D Christian, Pearl M. Swe, Kadaba S. Sriprakash, Katja Fischer, H. Lu

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005437 (2017)

Background On a global scale scabies is one of the most common dermatological conditions, imposing a considerable economic burden on individuals, communities and health systems. There is substantial epidemiological evidence that in tropical regions s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6391274359b539d31d41b3dfec43539
http://europepmc.org/articles/PMC5360341

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Parasitic scabies mites and associated bacteria joining forces against host complement defence

Autor: Pearl M. Swe, Simone L. Reynolds, Katja Fischer

Publikováno v: Parasite Immunology. 36:585-593

Scabies is a ubiquitous and contagious skin disease caused by the parasitic mite Sarcoptes scabiei Epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by Staphylococcus aureus and Streptococcus py

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e99903c621c1a4e5aced12b54e8f8ef
https://doi.org/10.1111/pim.12133

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Mode of action of dysgalacticin: a large heat-labile bacteriocin

Autor: Pearl M. Swe, Ralph W. Jack, Gregory M. Cook, John R. Tagg

Publikováno v: Journal of Antimicrobial Chemotherapy. 63:679-686

Objectives: The mode of action of dysgalacticin, a large (21.5 kDa), heat-labile bacteriocin that is active against the human pathogen Streptococcus pyogenes, was investigated. Methods: We used recombinant dysgalacticin to determine its mode of actio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2b99f81b447e23cad820a95911e4cd
https://doi.org/10.1093/jac/dkn552

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