Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Pearl Bakhru"'
Autor:
Arshad Khan, Vipul K. Singh, Abhishek Mishra, Emily Soudani, Pearl Bakhru, Christopher R. Singh, Dekai Zhang, David H. Canaday, Anjaneyulu Sheri, Seetharamaiyer Padmanabhan, Sreerupa Challa, Radhakrishnan P. Iyer, Chinnaswamy Jagannath
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) kills about 1.5 million people each year and the widely used Bacille Calmette-Guérin (BCG) vaccine provides a partial protection against TB in children and adults. Because BCG vaccine evad
Externí odkaz:
https://doaj.org/article/9b24ca6f73184c76b1c13fc31dc71761
Autor:
Meng-Lei Zhu, Pearl Bakhru, Bridget Conley, Jennifer S. Nelson, Meghan Free, Aaron Martin, Joshua Starmer, Elizabeth M. Wilson, Maureen A. Su
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for andr
Externí odkaz:
https://doaj.org/article/1221cac6180d456f84a5102f730cd069
Autor:
Jin Wang, Subramanian Dhandayuthapani, Dekai Zhang, Chandrashekhar Pasare, Kishore Das, Chinnaswamy Jagannath, Jianjun Sun, Arshad Khan, Robert L. Hunter, Jaymie L. Estrella, Emily Soudani, Sankaralingam Saikolappan, Pearl Bakhru, Christopher R. Singh, N. Tony Eissa, Yue Ma
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-19 (2019)
NPJ Vaccines
NPJ Vaccines
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M. tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children, but not adults against tuberculosis. BCG evades phagosome maturation, aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5fd43a56e2e43f9e3c366b2d4ef373
http://link.springer.com/article/10.1038/s41541-019-0122-8
http://link.springer.com/article/10.1038/s41541-019-0122-8
Autor:
Sreerupa Challa, Chinnaswamy Jagannath, Christopher R. Singh, Dekai Zhang, Vipul K. Singh, David H. Canaday, Radhakrishnan P. Iyer, Pearl Bakhru, Seetharamaiyer Padmanabhan, Emily Soudani, Abhishek Mishra, Anjaneyulu Sheri, Arshad Khan
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) kills about 1.5 million people each year and the widely used Bacille Calmette-Guérin (BCG) vaccine provides a partial protection against TB in children and adults. Because BCG vaccine evad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fee1a59b58ac5c20928eed786f7b4b
http://europepmc.org/articles/PMC7751440
http://europepmc.org/articles/PMC7751440
Autor:
Samantha Ottinger, Pearl Bakhru, Hsin-Jung Wu, Wilson Guzman, Michael Ophir, Michael March Schmidt, Leung Cheuk Lun, Nora Zizlsperger, Chao Wang, Ana C. Anderson, Robert Tighe, Sunny Q. He, Piotr Bobrowicz, Dana C. Gilmore, Conner Lambden, Benjamin Wolf, Lucy Liu, Jason Lajoie, Christine Cummings, William K. McConaughy, Thomas Joseph Schuetz, Ugur Eskiocak, William F. Carson, Lauren Milling
Publikováno v:
JCI Insight. 5
CD137 (4-1BB) is a member of the TNFR superfamily that represents a promising target for cancer immunotherapy. Recent insights into the function of TNFR agonist antibodies implicate epitope, affinity, and IgG subclass as critical features, and these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528666204f4a950748d3cb0a61422930
https://doi.org/10.1172/jci.insight.133647
https://doi.org/10.1172/jci.insight.133647
Autor:
Jennifer S. Nelson, Joshua Starmer, Aaron D. Martin, Maureen A. Su, Meng-Lei Zhu, Bridget Conley, Elizabeth M. Wilson, Pearl Bakhru, Meghan E. Free
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications
Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen levels in males. Androgen binds to the androgen receptor (AR) to regulate gene expression, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54395763e2de1befccb8af131c0ceca8
https://doaj.org/article/1221cac6180d456f84a5102f730cd069
https://doaj.org/article/1221cac6180d456f84a5102f730cd069
Autor:
Subramanian Dhandayuthapani, N. Tony Eissa, Jeffrey D. Cirillo, Emily Soudani, Sankaralingam Saikolappan, Pearl Bakhru, Christopher R. Singh, Chinnaswamy Jagannath, Arshad Khan
Publikováno v:
Autophagy, Infection, and the Immune Response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94cfeeeca3ddfa070ce7dea7caeeebd5
https://doi.org/10.1002/9781118677551.ch15
https://doi.org/10.1002/9781118677551.ch15
Autor:
Pearl Bakhru, Maureen A. Su
Publikováno v:
Journal of Clinical Investigation. 126:1239-1241
Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible to these diseases than males. Here, we analyzed human thymic transcriptome and revealed sex-associated differences in the expression of tissue-specific antigens t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f98be26a825a3089f06f7ba2602b3a
https://doi.org/10.1172/jci86800
https://doi.org/10.1172/jci86800
Autor:
Lee Kyung Hong, David Sailer, Ajay S. Gulati, Imran S. Khan, Joshua Starmer, Pearl Bakhru, Lawrence Fong, Fengmin Zhao, Sandra J. Lee, Maureen A. Su, Stergios J. Moschos, Maria L. Mouchess, Meng-Lei Zhu, John M. Kirkwood, Mark S. Anderson, Yafei Hou, Hsing-Hui Wang
Publikováno v:
JCI insight, vol 2, iss 18
Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients. Because checkpoint blockade acts by "removing the brakes" on effector T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32aec97d693d186815b4ee207acc096e
https://escholarship.org/uc/item/7ms747qt
https://escholarship.org/uc/item/7ms747qt
Autor:
Pearl Bakhru, Girish Hemashettar, Allison Nelson, Monia Draghi, Thomas Daly, Robert Tighe, Michael Schmidt, Wilson Guzman, Samantha Ottinger, Sara M. Haserlat, Rachel Rennard, Ugur Eskiocak, Benjamin Wolf, Jason Lajoie, Amanda Oliphant, Alan Leung, Lucy Liu
Publikováno v:
Cancer Research. 79:3239-3239
Blockade of inhibitory checkpoint pathways, such as PD-1/PD-L1 and CTLA-4, has provided significant benefit to subsets of patients and changed the cancer therapy landscape. These checkpoint inhibitors promote adaptive T cell-mediated anti-tumor immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dde4bbf75553e1b0bd6d90372982d26
https://doi.org/10.1158/1538-7445.am2019-3239
https://doi.org/10.1158/1538-7445.am2019-3239