Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pearce Gareth Edward Stephen"'
Autor:
Michael Rowley, Cristina Gardelli, Vincent Brett Cooper, Vincenzo Pucci, Frank Narjes, Claudio Giuliano, Pearce Gareth Edward Stephen, Fabrizio Fiore, Edith Monteagudo, Ralph Laufer, Simona Cianetti, Barbara Attenni
Publikováno v:
Drug Delivery. 17:214-222
The purpose of this study was to investigate the in vivo absorption enhancement of a nucleoside (phosphoramidate prodrug of 2'-methyl-cytidine) anti-viral agent of proven efficacy by means of intestinal permeation enhancers. Natural nucleosides are h
Autor:
I.J.F. Poplett, Elizabeth Balchin, Stephen A. C. Wren, John A. S. Smith, David John Malcolme-Lawes, Pearce Gareth Edward Stephen, Michael David Rowe
Publikováno v:
Analytical Chemistry. 77:3925-3930
Nuclear quadrupole resonance is a radio frequency (rf) spectroscopic technique, closely related to NMR, which can be used to detect signals from solids containing nuclei with spin quantum number1/2. It is nondestructive, highly specific and noninvasi
Autor:
Pearce Gareth Edward Stephen, Stephen A.C. Wren, Michael D. Rowe, John A. S. Smith, Jamie Barras, Elizabeth Tate, Kaspar Althoefer
Publikováno v:
Analytical Chemistry. 81:5574-5576
Pulsed (35)Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. On
Publikováno v:
The Journal of pharmacy and pharmacology. 55(9)
A Merck development compound was known to exist in several polymorphic forms, hydrates and solvates. The polymorphic forms were characterized and the most thermodynamically stable form at room temperature was identified and taken into development. Du
Autor:
Jayna Rose, Gibson Todd, Patricia Frech, Michael Wang, Paul Vincent Byway, Pratik Mehta, Yu Cheng, Pearce Gareth Edward Stephen, Shyam B. Karki, Danielle H. Euler, Gloria Y. Kwei, Christopher M. Lindemann, Cameron J. Cowden
Publikováno v:
International journal of pharmaceutics. 275(1-2)
In this paper, we describe the physicochemical and biopharmaceutical properties of 3-fluoro-2-pyrimidylmethyl 3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide, a direct thrombin inhibitor (1, Fig. 1). Three crystalline forms