KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation

Autor: Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ, UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS, Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ, UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS

Publikováno v: Cell.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::998f8007468bd6170371df0405ca8f25

Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.

Autor: Pearce LR; University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre (L.R.P., J.M.K., E.H., E.G.B., S.G., S.Sa., S.O., I.B., I.S.F.), Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ United Kingdom; Graduate Program in Cellular and Molecular Biology (R.J., C.C.-S.), Department of Molecular and Integrative Physiology (M.E.D., H.-W.S., L.S.A., J.M.C., L.R., C.C.-S.), and Division of Metabolism, Endocrinology, and Diabetes (C.C.-S.), Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-5622; Joslin Diabetes Center and Department of Medicine (S.Sh.), Harvard University, Boston, Massachusetts 02115; and Wellcome Trust Sanger Institute (I.B.), Hinxton, CB10 1SA United Kingdom., Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C

Publikováno v: Endocrinology [Endocrinology] 2014 Sep; Vol. 155 (9), pp. 3219-26. Date of Electronic Publication: 2014 Jun 27.

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

Autor: Doche ME; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-5622, USA., Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi IS

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2012 Dec; Vol. 122 (12), pp. 4732-6. Date of Electronic Publication: 2012 Nov 19.

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Autor: Pearce LR; MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, U.K. l.r.pearce@dundee.ac.uk, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR

Publikováno v: The Biochemical journal [Biochem J] 2010 Oct 15; Vol. 431 (2), pp. 245-55.

New insights into mTOR signaling: mTORC2 and beyond.

Autor: Alessi DR; MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK. d.r.alessi@dundee.ac.uk, Pearce LR, García-Martínez JM

Publikováno v: Science signaling [Sci Signal] 2009 Apr 21; Vol. 2 (67), pp. pe27. Date of Electronic Publication: 2009 Apr 21.