Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab

Autor: Macrae, FL, Peacock‐Young, B, Bowman, P, Baker, SR, Quested, S, Linton, E, Hillmen, P, Griffin, M, Munir, T, Payne, D, McKinley, C, Clarke, D, Newton, DJ, Hill, A, Ariëns, RAS

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement‐mediated intravascular hemolysis and thrombosis. The increased incidence of PNH‐driven thrombosis is still poorly understood, but unlike other

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https://eprints.whiterose.ac.uk/161714/1/ajh.25841.pdf

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Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab.

Autor: Macrae FL; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Peacock-Young B; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Bowman P; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Baker SR; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.; Department of Physics, Wake Forest University, Winston Salem, North Carolina, USA., Quested S; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Linton E; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Hillmen P; Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Griffin M; Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Munir T; Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Payne D; Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., McKinley C; Division of Haematology and Immunology, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Clarke D; Division of Haematology and Immunology, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Newton DJ; Division of Haematology and Immunology, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Hill A; Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Ariëns RAS; Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

Publikováno v: American journal of hematology [Am J Hematol] 2020 Aug; Vol. 95 (8), pp. 944-952. Date of Electronic Publication: 2020 May 11.