Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells

Autor: Teasdale, JE, Hazell, GGJ, Peachey, AMG, Sala-Newby, GB, Hindmarch, CCT, McKay, T, Bond, M, Newby, AC, White, SJ

Publikováno v: Teasdale, J E, Hazell, G G J, Peachey, A M G, Sala-Newby, G B, Hindmarch, C C T, McKay, T R, Bond, M, Newby, A C & White, S J 2017, ' Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells ', Scientific Reports, vol. 7, 39945 . https://doi.org/10.1038/srep39945

Endothelial dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants derived from cigarette smoke is known to promote coronary atherosclerosis and increase the likelihood of myocardial infarctions and strokes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fb80990e69abc9bfbcb703dcbec4d41a
https://research-information.bris.ac.uk/en/publications/a0e81246-0381-4d52-984b-8a907961bd1b