Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase.

Autor: O'Carroll SM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Peace CG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Toller-Kawahisa JE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Min Y; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Charki S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Kehoe L; Histology Lab, Children's Health Ireland at Crumlin, Dublin, Ireland., O'Sullivan MJ; Histology Lab, Children's Health Ireland at Crumlin, Dublin, Ireland.; Departments of Histopathology and Paediatrics, Trinity College Dublin, Dublin, Ireland., Zoller A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Mcgettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Day EA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Simarro M; Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, Valladolid, Spain.; Unit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain., Armstrong N; Department of Medicine, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., Annes JP; Department of Medicine, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. laoneill@tcd.ie.

Publikováno v: Nature metabolism [Nat Metab] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.

Inflammatory mitochondrial nucleic acids as drivers of pathophysiology.

Autor: Peace CG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Dublin, Ireland., Hooftman A; Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland., Ryan DG; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2023 Sep; Vol. 13 (9), pp. e1403.

Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.

Autor: Ryan TAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Rehill AM; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Johansen MD; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia., O' Brien EC; Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Toller-Kawahisa JE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Wilk MM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.; Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland., Day EA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Weiss HJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Sarvari P; Center for Infection and Genomics of the Lung, German Center for Lung Research (DZL), Faculty of Medicine, Justus Liebig University, Giessen, Germany., Vozza EG; Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Schramm F; Center for Infection and Genomics of the Lung, German Center for Lung Research (DZL), Faculty of Medicine, Justus Liebig University, Giessen, Germany., Peace CG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Zotta A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Miemczyk S; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia., Nalkurthi C; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia., Hansbro NG; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia., McManus G; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., O'Doherty L; Department of Infectious Diseases, St. James's Hospital, Dublin, Ireland.; Clinical Research Facility, St. James's Hospital, Dublin, Ireland.; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Gargan S; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Long A; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Dunne J; Department of Immunology, St James's Hospital, Dublin, Ireland., Cheallaigh CN; Department of Infectious Diseases, St. James's Hospital, Dublin, Ireland.; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Conlon N; Clinical Research Facility, St. James's Hospital, Dublin, Ireland.; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Department of Immunology, St James's Hospital, Dublin, Ireland., Carty M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Fallon PG; Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland., Mills KHG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Creagh EM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., O' Donnell JS; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Hertzog PJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Hansbro PM; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, Sydney, NSW, Australia., McLoughlin RM; Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Wygrecka M; Center for Infection and Genomics of the Lung, German Center for Lung Research (DZL), Faculty of Medicine, Justus Liebig University, Giessen, Germany., Preston RJS; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Zasłona Z; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. laoneill@tcd.ie.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 20; Vol. 14 (1), pp. 4374. Date of Electronic Publication: 2023 Jul 20.

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.

Autor: Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. ahooftma@tcd.ie., Peace CG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Ryan DG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. dr523@cam.ac.uk.; MRC Cancer Unit, University of Cambridge, Cambridge, UK. dr523@cam.ac.uk.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. dr523@cam.ac.uk., Day EA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Yang M; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; CECAD Research Centre, Faculty of Medicine, University of Cologne, Cologne, Germany., McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Yin M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Montano EN; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Huo L; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Toller-Kawahisa JE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Zecchini V; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Ryan TAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Bolado-Carrancio A; Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK., Casey AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Costa ASH; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Matterworks, Somerville, MA, USA., De Los Santos G; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ishimori M; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Wallace DJ; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Venuturupalli S; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Nikitopoulou E; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Frizzell N; School of Medicine, University of South Carolina, Columbia, SC, USA., Johansson C; National Heart and Lung Institute, Imperial College London, London, UK., Von Kriegsheim A; Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Jefferies C; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Frezza C; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; CECAD Research Centre, Faculty of Medicine, University of Cologne, Cologne, Germany., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. laoneill@tcd.ie.

Publikováno v: Nature [Nature] 2023 Mar; Vol. 615 (7952), pp. 490-498. Date of Electronic Publication: 2023 Mar 08.

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.

Autor: Runtsch MC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: runtschm@tcd.ie., Angiari S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Wadhwa R; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia., Zhang Y; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China., Zheng Y; Drug Discovery Science & Technology, AbbVie Inc., 1 North Waukegon Road, North Chicago, IL 60064, USA., Spina JS; AbbVie, Bio Research Center, 100 Research Drive, Worcester, MA 01608, USA., Ruzek MC; AbbVie, Bio Research Center, 100 Research Drive, Worcester, MA 01608, USA., Argiriadi MA; AbbVie, Bio Research Center, 100 Research Drive, Worcester, MA 01608, USA., McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Mendez RS; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Zotta A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Peace CG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Walsh A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Chirillo R; Department of Experimental and Clinical Medicine, 'Magna Græcia' University of Catanzaro, Catanzaro, Italy., Hams E; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Fallon PG; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Jayamaran R; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia., Dua K; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia., Brown AC; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Kim RY; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Horvat JC; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Hansbro PM; Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia., Wang C; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: laoneill@tcd.ie.

Publikováno v: Cell metabolism [Cell Metab] 2022 Mar 01; Vol. 34 (3), pp. 487-501.e8.