Výsledky vyhledávání - "PeBoW complex"

Estructura y función del complejo PeBoW como modelo en el desarrollo de posibles herramientas terapéuticas

Autor: Orea-Ordóñez, Lidia

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
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[ES] La biogénesis ribosomal es uno de los procesos más complejos, esenciales y costosos energéticamente de la célula eucariota. La formación de las subunidades ribosomales en levaduras comienza en el nucléolo con la transcripción del ARNr. En

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7dd6b268685312457aa4b3020efb8c
https://doi.org/10.4995/thesis/10251/182347

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Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth

Autor: Lishu Chen, Tao Zhou, Ji Qi, Lanjuan Mi, Haowen Ran, Yan Cai, Dake Xiao, Jianghong Man, Jiaqi Wu, Yuanyuan Li, Tao Li, Fangye Li, Haohao Huang, Bohan Li, Qinghui Qi, Jiong Xie, Songyang Zhang, Ailing Li, Da Li

Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology

Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor. Ribosome biogenesis is an essential cellular process to maintain cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b442534e6c382c8367682943ee1abbb
https://www.frontiersin.org/articles/10.3389/fonc.2021.751792/full

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The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin

Autor: Erin M. Romes, Robin E. Stanley, Mack Sobhany

Publikováno v: Journal of Biological Chemistry. 291:882-893

The synthesis of eukaryotic ribosomes is a complex, energetically demanding process requiring the aid of numerous non-ribosomal factors, such as the PeBoW complex. The mammalian PeBoW complex, composed of Pes1, Bop1, and WDR12, is essential for the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5e7f4813ab6645be70ddb7cb60431b
https://doi.org/10.1074/jbc.m115.693259

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Structural, biophysical and functional characterization of Nop7-Erb1-Ytm1 complex and its implications in eukaryotic ribosome biogenesis

Autor: Marcin Wegrecki

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia

[EN] Ribosome biogenesis is one of the most important and energy-consuming processes in the cell. However, the vast majority of the events and factors that are involved in the synthesis of ribosomal subunits are not well understood. Ribosome maturati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8982a26f4111e3d0e1b0fc50e965f19a
https://doi.org/10.4995/thesis/10251/55941

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WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

Autor: Jaana Rysä, Margret Leosdottir, Risto Kerkelä, Zoltan Szabo, Leena Kaikkonen, Zsolt Bagyura, Heikki Ruskoaho, Juha Näpänkangas, Pauli Ohukainen, Teemu Karvonen, Raisa Serpi, Olli Tenhunen, Björn Wahlstrand, Anne-Mari Moilanen, Pasi Tavi, Erja Mustonen, Thomas Hedner, Olle Melander

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0124907 (2015)
PLoS ONE; 10(4), no e0124907 (2015)

Aims In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI). However, the function of WDR12 in the heart is unknown. Methods and Results We characterized cardiac expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac478079c779aa8834240bc2c0026898
http://hdl.handle.net/10138/164375

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Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation

Autor: Thomas Grimm, Dirk Eick, Michaela Rohrmoser, Anita Gruber-Eber, Martin Schlee, Georg W. Bornkamm, Anastassia Malamoussi, Elisabeth Kremmer, Michael Hölzel, Thomas Harasim, Wolfgang Hiddemann

Publikováno v: The Journal of Cell Biology

Target genes of the protooncogene c-myc are implicated in cell cycle and growth control, yet the linkage of both is still unexplored. Here, we show that the products of the nucleolar target genes Pes1 and Bop1 form a stable complex with a novel membe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81842ab87058fd1423d9f0225ef8e9a0
https://doi.org/10.1083/jcb.200501141

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DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex

Autor: Michaela Rohrmoser, Axel Imhof, Kirsten Voss, Kaspar Burger, Elisabeth Kremmer, Bastian Mühl, Anita Gruber-Eber, Markus Kellner, Ignasi Forné, Dirk Eick

Publikováno v: Experimental cell research. 334(1)

PeBoW, a trimeric complex consisting of pescadillo (Pes1), block of proliferation (Bop1), and the WD repeat protein 12 (WDR12), is essential for processing and maturation of mammalian 5.8S and 28S ribosomal RNAs. Applying a mass spectrometric analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b664b4d7a296adb5095a8dad0881fec
https://pubmed.ncbi.nlm.nih.gov/25825154

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