Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Péter Ábrányi-Balogh"'
Autor:
Péter Ábrányi-Balogh, Dávid Bajusz, Zoltán Orgován, Aaron B. Keeley, László Petri, Nikolett Péczka, Tibor Viktor Szalai, Gyula Pálfy, Márton Gadanecz, Emma K. Grant, Tímea Imre, Tamás Takács, Ivan Ranđelović, Marcell Baranyi, András Marton, Gitta Schlosser, Qirat F. Ashraf, Elvin D. de Araujo, Tamás Karancsi, László Buday, József Tóvári, András Perczel, Jacob T. Bush, György M. Keserű
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Fragment screening is a popular strategy of generating viable chemical starting points especially for challenging targets. Although fragments provide a better coverage of chemical space and they have typically higher chance of binding, their
Externí odkaz:
https://doaj.org/article/0a79f05dcd144d4ba343eaa1f806db99
Autor:
Zsuzsanna Szalai, Márton Debrei, Péter Ábrányi-Balogh, Szilvia Bősze, Rita Oláhné Szabó, Konstantin Karaghiosoff, László Drahos, György Keglevich
Publikováno v:
ACS Omega, Vol 9, Iss 28, Pp 31043-31055 (2024)
Externí odkaz:
https://doaj.org/article/ff3b9d937f954a5381774f5b3bee5f08
PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells
Autor:
Susanne Prokop, Péter Ábrányi-Balogh, Benjámin Barti, Márton Vámosi, Miklós Zöldi, László Barna, Gabriella M. Urbán, András Dávid Tóth, Barna Dudok, Attila Egyed, Hui Deng, Gian Marco Leggio, László Hunyady, Mario van der Stelt, György M. Keserű, István Katona
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The authors introduce PharmacoSTORM single-molecule imaging that uses fluorescent ligands and immunolabeling for cellular and subcellular nanoscale molecular pharmacology. They demonstrate its capabilities by visualizing cariprazine binding to D3 dop
Externí odkaz:
https://doaj.org/article/7fdcba0c8de84fc9bca36e38db68d9ba
Autor:
László Petri, Péter Ábrányi-Balogh, Noémi Csorba, Aaron Keeley, József Simon, Ivan Ranđelović, József Tóvári, Gitta Schlosser, Dániel Szabó, László Drahos, György M. Keserű
Publikováno v:
Molecules, Vol 28, Iss 7, p 3042 (2023)
SuFEx chemistry is based on the unique reactivity of the sulfonyl fluoride group with a range of nucleophiles. Accordingly, sulfonyl fluorides label multiple nucleophilic amino acid residues, making these reagents popular in both chemical biology and
Externí odkaz:
https://doaj.org/article/c77c5ffab3114b2793cf463335f0bda9
Autor:
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded
Externí odkaz:
https://doaj.org/article/d499338758524d99942f9963faf75661
Autor:
Csilla Hargitai, Györgyi Koványi-Lax, Tamás Nagy, Péter Ábrányi-Balogh, András Dancsó, Gábor Tóth, Judit Halász, Angéla Pandur, Gyula Simig, Balázs Volk
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1636-1648 (2020)
Treatment of alkoxy-substituted o-(pivaloylaminomethyl)benzaldehydes under acidic conditions resulted in the formation of the regioisomeric aldehydes and/or dimer-like products. Detailed NMR studies and single-crystal X-ray measurements supported the
Externí odkaz:
https://doaj.org/article/4519f43ebccc4132b2066bfbe53f84d2
Autor:
Péter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György M. Keserű
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1484 (2022)
Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electr
Externí odkaz:
https://doaj.org/article/df22a37fca3f4388a828d755b3209126
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1523-1533 (2019)
A new multicomponent reaction has been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O-thiocarbamates and dithiocarbamates in moderate to good yields. The one-pot reaction cascade involves the f
Externí odkaz:
https://doaj.org/article/69a2cd8ebb244eabb1bd58fe1e8e595e
Publikováno v:
Molecules, Vol 27, Iss 15, p 4674 (2022)
The microwave (MW)-assisted direct esterification of certain P-acids is a green method. Quantum chemical calculations revealed that the activation enthalpy (ΔH#) for the exothermic monoalkylphosphate → dialkylphosphate transformation was on the av
Externí odkaz:
https://doaj.org/article/d11bb555c2b544ae8b93f4bcdad161b8
Autor:
Levente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry, László Petri, Péter Ábrányi-Balogh, Dorottya Csányi, György G. Ferenczy, Stanislav Gobec, Izidor Sosič, György M. Keserű
Publikováno v:
Cells, Vol 10, Iss 12, p 3431 (2021)
Constitutive- and immunoproteasomes are part of the ubiquitin–proteasome system (UPS), which is responsible for the protein homeostasis. Selective inhibition of the immunoproteasome offers opportunities for the treatment of numerous diseases, inclu
Externí odkaz:
https://doaj.org/article/ad5fe72dbb704a139bb1f472787654f3