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Synthetic routes to cationic isothiocyanato di- and tetraphenyl porphyrins and their conjugation to monoclonal antibodies for use in PDT

Autor: Peša, Nela, Smith, Karen

Several synthetic routes to cationic isothiocyanato di- and tetraphenyl porphyrins are presented. These poprhyrins were successfully conjugated to monoclonal antibodies for use in PDT. The binding properties of resulting bioconjugates are described a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::a9d7a853a7d85d838cc95c379172b6e3
https://www.bib.irb.hr/505006

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Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT

Autor: Staneloudi, Chrysovalanto, Smith, Karen A., Hudson, Robert, Peša, Nela, Savoie, Huguette, Boyle, Ross W., Greenman, John

An expression system giving high yield of scFv fragments has been established. The molar ratios at which the conjugation to scFv was carried out has been optimized. These immunoconjugates showed low levels of non-covalently associated porphyrin, mini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4fcfacd1239ff646b8088db2dfe362a3
https://www.bib.irb.hr/329888

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An efficient preparation of beta-dimethylaminovinyl sulfone and sulfoximide, and investigation of their reactivity as dipolarophiles

Autor: Peša, Nela, Welch, Chris J., Boa, Andrew N.

A simple reaction affording (E)-1-dimethylamino-2-phenylsulfonylethylene, and S-((E)-2-(N', N'-dimethylamino)ethenyl)-S-phenyl-N-(p-tolylsulfonyl) sulfoximide in high yields is described. A reversal in regioselectivity was observed when the beta-dime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::a1bfbe61cb414f3a55fe45da32282980
https://www.bib.irb.hr/329502

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Synthetic routes to 5-(4-isothiocyanatophenyl)-15-(4-pyridinumyl) porphyrins and bacteriochlorins and their bioconjugation for targeted photodynamic therapy

Autor: Peša, Nela

The synthesis of three cationic 5, 15-diphenyl porphyrins, bearing an isothiocyanate group for conjugation to proteins is described. The routes to their chlorin and bacteriochlorin analogues are investigated. The potential of these compounds as targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::fafeab7e133c5171df59baacbe288d26
https://www.bib.irb.hr/505007

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A study of reactions of sulphur containing dipolarophiles with 1, 3-dipoles

Autor: Peša, Nela

Several different methods for the synthesis of vinyl sulfoximines and sulfoxides have been investigated, and the products obtained have been investigated as dipolarophiles in 1, 3-dipolar cycloadditions with nitrile imines and nitrile oxides. Also, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::08283343bd3e80a1f907c58e6478da09
https://www.bib.irb.hr/329726

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