SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

Autor: Sofia Lachiondo-Ortega, Claudia M. Rejano-Gordillo, Jorge Simon, Fernando Lopitz-Otsoa, Teresa C. Delgado, Krystyna Mazan-Mamczarz, Naroa Goikoetxea-Usandizaga, L. Estefanía Zapata-Pavas, Ana García-del Río, Pietro Guerra, Patricia Peña-Sanfélix, Natalia Hermán-Sánchez, Ruba Al-Abdulla, Carmen Fernandez-Rodríguez, Mikel Azkargorta, Alejandro Velázquez-Cruz, Joris Guyon, César Martín, Juan Diego Zalamea, Leire Egia-Mendikute, Arantza Sanz-Parra, Marina Serrano-Maciá, Irene González-Recio, Monika Gonzalez-Lopez, Luis Alfonso Martínez-Cruz, Patrizia Pontisso, Ana M. Aransay, Rosa Barrio, James D. Sutherland, Nicola G.A. Abrescia, Félix Elortza, Amaia Lujambio, Jesus M. Banales, Raúl M. Luque, Manuel D. Gahete, Asís Palazón, Matias A. Avila, Jose J. G. Marin, Supriyo De, Thomas Daubon, Antonio Díaz-Quintana, Irene Díaz-Moreno, Myriam Gorospe, Manuel S. Rodríguez, María Luz Martínez-Chantar

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113924- (2024)

Summary: The posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, we show that HuR is

Externí odkaz: https://doaj.org/article/ac05448b67bf43d08eefd6737eb5e995

Modulatory effects of CNNM4 on Protein-L-Isoaspartyl-O-Methyltransferase repair function during Alcohol-Induced hepatic damage.

Autor: González-Recio I; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Goikoetxea-Usandizaga N; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Health Institute, Madrid, Spain., Rejano-Gordillo CM; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain.; Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Extremadura, University Institute of Biosanitary Research of Extremadura (INUBE), 06071 Badajoz, Spain.; Biofisika Institute, Consejo Superior de Investigaciones Científicas (CSIC), Departamento Bioquímica y Biología Molecular, Facultad de Ciencia y Tecnología, Universidad del País Vasco (UPV/EHU), Leioa, Spain., Conter C; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Rodríguez Agudo R; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Serrano-Maciá M; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Zapata-Pavas LE; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Peña-Sanfélix P; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Azkargorta M; Proteomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Elortza F; Proteomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Herranz JM; Hepatology Programme, CIMA, Idisna, Universidad de Navarra, Avda, Pio XII, n 55, 31008 Pamplona, Spain., Guillamon Thiery Á; Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Catalonia, Spain., Guerra-Ruiz AR; Clinical Biochemistry Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain., Jover R; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Health Institute, Madrid, Spain.; Experimental Hepatology Joint Research Unit, IIS Hospital La Fe & Dep. Biochemistry, University of Valencia, Spain., Galicia-Garcia U; Biofisika Institute, Consejo Superior de Investigaciones Científicas (CSIC), Departamento Bioquímica y Biología Molecular, Facultad de Ciencia y Tecnología, Universidad del País Vasco (UPV/EHU), Leioa, Spain., Martín C; Biofisika Institute, Consejo Superior de Investigaciones Científicas (CSIC), Departamento Bioquímica y Biología Molecular, Facultad de Ciencia y Tecnología, Universidad del País Vasco (UPV/EHU), Leioa, Spain., Schaeper U; Silence Therapeutics GmbH, Berlin, Robert Rössle Strasse 10, 13125, Berlin, Germany., Delgado TC; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Díaz-Moreno I; Institute for Chemical Research (IIQ), Scientific Research Centre 'Isla de la Cartuja' (cicCartuja), University of Seville - CSIC, Avda. Américo Vespucio 49, 41092 Seville, Spain., Díaz Quintana A; Departamento de Bioquímica Vegetal y Biologia Molecular, Facultad de Biología, Universidad de Sevilla, C. San Fernando 4, 41004 Sevilla (Spain)., Buccella D; Department of Chemistry, New York University, New York, New York 10003, United States., Nogueiras R; Molecular Metabolism Lab, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Av. Barcelona, Campus Vida, Santiago de Compostela University, 15782 Santiago de Compostela, Spain., Argemi J; Hepatology Program, Centro de Investigación Médica Aplicada (CIMA), Liver Unit, Clinica Universidad de Navarra (CUN), Instituto de Investigación de Navarra (IdisNA), University of Navarra, Pamplona, Spain.; Center for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA., Ávila MA; Hepatology Programme, CIMA, Idisna, Universidad de Navarra, Avda, Pio XII, n 55, 31008 Pamplona, Spain., Gratacós-Ginès J; Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Catalonia, Spain., Iruzubieta P; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain., Pose E; Hospital Clinic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Catalonia, Spain., Bataller R; Center for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA., Crespo J; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain., Martínez-Cruz LA; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain., Martínez-Chantar ML; Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Health Institute, Madrid, Spain.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.

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