Resveratrol and ivacaftor are additive G551D CFTR channel potentiators: Therapeutic implications for cystic fibrosis sinus disease

Autor: Cho, Do-Yeon, Zhang, Shaoyan, Lazrak, Ahmed, Grayson, Jessica W., Peña Garcia, Jaime A., Skinner, Daniel F., Lim, Dong Jin, Mackey, Calvin, Banks, Catherine, Matalon, Sadis, Woodworth, Bradford A.

INTRODUCTION: Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene result in defective Cl(−) transport and cause chronic bacterial infections in the upper and lower airways of cystic fibrosis (CF) patients. Ivacaftor is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf4b6d107345c6545698f40a4e0a15e6
https://europepmc.org/articles/PMC6318032/

Resveratrol and ivacaftor are additive G551D CFTR‐channel potentiators: therapeutic implications for cystic fibrosis sinus disease.

Autor: Cho, Do‐Yeon, Zhang, Shaoyan, Lazrak, Ahmed, Grayson, Jessica W., Peña Garcia, Jaime A., Skinner, Daniel F., Lim, Dong Jin, Mackey, Calvin, Banks, Catherine, Matalon, Sadis, Woodworth, Bradford A.

Publikováno v: International Forum of Allergy & Rhinology; Jan2019, Vol. 9 Issue 1, p100-105, 6p

l-Methionine anti-biofilm activity against Pseudomonas aeruginosa is enhanced by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor.

Autor: Cho DY; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL.; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL., Lim DJ; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Mackey C; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Weeks CG; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Peña Garcia JA; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Skinner D; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Grayson JW; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Hill HS; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Alexander DK; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Zhang S; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL., Woodworth BA; Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL.

Publikováno v: International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2018 May; Vol. 8 (5), pp. 577-583. Date of Electronic Publication: 2018 Feb 07.