Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative

Autor: Peçanha Emerson P., Fraga Carlos A. M., Barreiro Eliezer J., Braga Maria F. M., Pereira Edna F. R., Albuquerque Edson X.

Publikováno v: Journal of the Brazilian Chemical Society, Vol 12, Iss 3, Pp 408-412 (2001)

As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyc

Externí odkaz: https://doaj.org/article/96523a1a36cd4a289e92588a78a7f05a

Síntese de β-cetoésteres cíclicos: novo procedimento para ciclizações de Dieckmann empregando ALCL3 e trietilamina

Autor: Peçanha, Emerson P., Barreiro, Eliezer J., Fraga, Carlos A. M.

Publikováno v: Química Nova, Volume: 20, Issue: 4, Pages: 435-437, Published: AUG 1997

In this communication we describe a new methodology to Dieckmann cyclization of diethyl adipate (1) and diethyl pimelate (3) applying "push-pull" strategy using anhydrous aluminium trichloride and triethylamine in dichloromethane at room temperature.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______608::1522655ea9395f840030e8ad73139ff5
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421997000400016&lng=en&tlng=en

Highly diastereoselective mercury-mediated synthesis of functionalized 2-azabicyclo[3.3.0]octane derivatives

Autor: Peçanha, Emerson P.^1,2, Verli, Hugo^1,2, Rodrigues, Carlos R.¹, Barreiro, Eliezer J.^1,2, Fraga, Carlos A. M.^1,2 cmfraga@pharma.ufrj.br

Publikováno v: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Feb2002, Vol. 43 Issue 9, p1607. 5p.

Synthesis and anti-HIV activity of new C2 symmetric derivatives designed as HIV-1 protease inhibitors.

Autor: Peçanha EP; Laboratorio 641, Ilha do Fundao, Instituto de Química, Universidade do Brasil, Cidade Universitária, CT Bloco A, Rio de Janeiro, RJ 21945-970, Brazil., Figueiredo LJ, Brindeiro RM, Tanuri A, Calazans AR, Antunes OA

Publikováno v: Farmaco (Societa chimica italiana : 1989) [Farmaco] 2003 Feb; Vol. 58 (2), pp. 149-57.