The role of Ca2+ in the release of pancreatic islet hormones

Autor: Hellman B, Erik Gylfe, Bergsten P, Grapengiesser E, Pe, Lund, Berts A, Dryselius S, Tengholm A, Yj, Liu, Eberhardson M

Publikováno v: Europe PubMed Central

The role of Ca2+ in initiating exocytosis of granule-bound secretory products was evaluated with respect to pancreatic islet hormones. Apart from stimulating the transfer of the granules to the plasma membrane and their subsequent extrusion, a rise o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f05f13931351a931a8e262d7f5e3b72f
https://pubmed.ncbi.nlm.nih.gov/7805949

Leucine induces initial lowering of cytoplasmic Ca2+ in pancreatic beta-cells without concomitant inhibition of insulin release

Autor: Pe, Lund, Erik Gylfe, Hellman B

Publikováno v: Europe PubMed Central

The early effects of glucose and leucine on cytoplasmic Ca2+ and insulin release were compared in suspensions of cells prepared by dispersal of the beta-cell-rich pancreatic islets of ob/ob-mice. Adequate temporal resolution was achieved by continuou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bad17626ea72de6650e0838061f5d576
http://europepmc.org/abstract/med/2673247

Single-molecule FRET observes opposing effects of urea and TMAO on structurally similar meso- and thermophilic riboswitch RNAs.

Autor: Hou Q; Single Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.; Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medicine, The Rockefeller University, Memorial Sloan Kettering Cancer Center, NY, NY 10021, USA., Chatterjee S; Single Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Physics, Case Western Reserve University, Cleveland, Ohio 44106, USA., Lund PE; Single Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA., Suddala KC; Single Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA., Walter NG; Single Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Nov 10; Vol. 51 (20), pp. 11345-11357.

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Autor: Balboa D; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain., Barsby T; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lithovius V; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Saarimäki-Vire J; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Omar-Hmeadi M; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Dyachok O; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Montaser H; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lund PE; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Yang M; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Ibrahim H; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Näätänen A; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Chandra V; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Vihinen H; Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Jokitalo E; Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Kvist J; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Ustinov J; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Nieminen AI; Metabolomics Unit, Institute for Molecular Medicine Finland, Helsinki, Finland., Kuuluvainen E; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Hietakangas V; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Program, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Katajisto P; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Lau J; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Carlsson PO; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Barg S; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Tengholm A; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Otonkoski T; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. timo.otonkoski@helsinki.fi.; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. timo.otonkoski@helsinki.fi.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2022 Jul; Vol. 40 (7), pp. 1042-1055. Date of Electronic Publication: 2022 Mar 03.

Granulomatosis with polyangiitis and cardio vascular co-morbidity in Denmark. A registry-based study of 21 years of follow-up.

Autor: Laustrup H; Department of Rheumatology, Odense University Hospital, Denmark., Voss A; Department of Rheumatology, Odense University Hospital, Denmark., Lund PE; Master of Science: Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.

Publikováno v: Journal of translational autoimmunity [J Transl Autoimmun] 2021 Nov 19; Vol. 4, pp. 100136. Date of Electronic Publication: 2021 Nov 19 (Print Publication: 2021).