Zobrazeno 1 - 10
of 5 785
pro vyhledávání: '"Pdac"'
Autor:
Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tu
Externí odkaz:
https://doaj.org/article/a2c84c9d9241460d889b4c891a5bea32
Unveiling the microRNA landscape in pancreatic ductal adenocarcinoma patients and cancer cell models
Autor:
Grazia Fenu, Carmen Griñán-Lisón, Andrea Pisano, Aitor González-Titos, Cristiano Farace, Giovanni Fiorito, Federica Etzi, Teresa Perra, Angela Sabalic, Belén Toledo, Macarena Perán, Maria Giuliana Solinas, Alberto Porcu, Juan Antonio Marchal, Roberto Madeddu
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to late-stage diagnoses resulting from nonspecific early symptoms and the absence of early diagnostic biomarkers. MicroRNAs (miRNAs) play a crucial role in
Externí odkaz:
https://doaj.org/article/92f9560de5734c30960654cf42e7dd4c
Autor:
Aiora Cenigaonandia‐Campillo, Ana Garcia‐Bautista, Anxo Rio‐Vilariño, Arancha Cebrian, Laura delPuerto, José Antonio Pellicer, José Antonio Gabaldón, Horacio Pérez‐Sánchez, Miguel Carmena‐Bargueño, Carolina Meroño, Javier Traba, María Jesús Fernandez‐Aceñero, Natalia Baños‐Herraiz, Lorena Mozas‐Vivar, Estrella Núñez‐Delicado, Jesús Garcia‐Foncillas, Óscar Aguilera
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2212-2233 (2024)
In pancreatic ductal adenocarcinoma (PDAC), metabolic rewiring and resistance to standard therapy are closely associated. PDAC cells show enormous requirements for glucose‐derived citrate, the first rate‐limiting metabolite in the synthesis of ne
Externí odkaz:
https://doaj.org/article/15680545600940349d1f3088fd3a5d0b
Autor:
Musitaba MUTAILIFU, WANG Junjie, QIAN Yunzhen, CHEN Suyuan, SHAO Da, ZHANG Zhigang, LI Dongxue
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 9, Pp 1104-1114 (2024)
Objective·To establish a mouse model with dormant cancer and no obvious metastasis by combining the preimmune strategy with the mVenus-p27K－ cell G0 phase indicator system, the DTR-HSV/TK suicide gene system, and the Luc2-tdTomato tracer system.Me
Externí odkaz:
https://doaj.org/article/d99722cb31a74969a0af800a8e9c1fbb
Autor:
Juan Zhang, Hongxi Xu, Yulin Wu, William Chi Shing Cho, Yang Li, Peiyao Ren, Yanfang Xian, Zhixiu Lin
Publikováno v:
Acta Materia Medica, Vol 3, Iss 3, Pp 312-327 (2024)
Chemoresistance to gemcitabine (Gem) remains a substantial obstacle in the treatment of pancreatic ductal adenocarcinoma carcinoma (PDAC). Nrf2, a transcription factor responsive to oxidative stress, has been implicated as a key contributor to chemor
Externí odkaz:
https://doaj.org/article/f730db7dae1040a6882785f4c8debe74
Autor:
Han Yin, Fernanda Romero-Hernandez, Amir Ashraf Ganjouei, Jaeyun Jane Wang, Audrey Brown, Kenzo Hirose, Ajay V. Maker, Eric Nakakura, Carlos Corvera, Kimberly S. Kirkwood, Alexander Wilhelm, June S. Peng, Adnan Alseidi, Mohamed A. Adam
Publikováno v:
Current Oncology, Vol 31, Iss 9, Pp 5008-5020 (2024)
Pancreatoblastoma is perceived to be aggressive in adults; however, data are limited due to the rarity of the disease. We benchmarked clinico-pathologic characteristics, outcomes, and survival of adult patients with pancreatoblastoma to a comparable
Externí odkaz:
https://doaj.org/article/f087753634584029a5321f4400fab754
Autor:
Ding-zhong Li, Zhe-yu Yang, Asi leng, Qian Zhang, Xiao-dong Zhang, Yan-chao Bian, Rui Xiao, Jian-jun Ren
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-15 (2024)
Abstract Background AGTPBP1 is a cytosolic carboxypeptidase that cleaves poly-glutamic acids from the C terminus or side chains of α/β tubulins. Although its dysregulated expression has been linked to the development of non-small cell lung cancer,
Externí odkaz:
https://doaj.org/article/5901ba18539a4e12a853ee0cffcbc55b
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal tumor with an ill-defined pathogenesis. DExD box (DDX) family genes are widely distributed and involved in various RNA metabolism and cellular biogenesis; their dysregulat
Externí odkaz:
https://doaj.org/article/1f8a4e614dd843c7865bebd72ab98241
Autor:
Nnenna Elebo, Ebtesam A. Abdel-Shafy, Jones A. O. Omoshoro-Jones, Zanele Nsingwane, Ahmed A. A. Hussein, Martin Smith, Geoffrey Candy, Stefano Cacciatore, Pascaline Fru, Ekene Emmanuel Nweke
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer characterized by an immunosuppressive microenvironment. Patients from specific ethnicities and population groups have poorer prognoses than others. Therefore, a bette
Externí odkaz:
https://doaj.org/article/88510bf4372d4dd9a9b6c718c4a12312
Autor:
Eszter Molnár, Marcell Baranyi, Krisztina Szigeti, Luca Hegedűs, Fanni Bordás, Zsófia Gábriel, Gréta Petényi, József Tóvári, Balázs Hegedűs, József Tímár
Publikováno v:
Pathology and Oncology Research, Vol 30 (2024)
Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options. A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target. The introduction of new KRAS inhibi
Externí odkaz:
https://doaj.org/article/218556c3ae364339970c587752baa280