Zobrazeno 1 - 10 of 548 pro vyhledávání: '"Pd, Robbins"'
1
Akademický článek
Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics
Autor: R Hartman, P Patil, R Tisherman, C St. Croix, LJ Niedernhofer, PD Robbins, F Ambrosio, B Van Houten, G Sowa, N Vo
Publikováno v: European Cells & Materials, Vol 36, Pp 171-183 (2018)
Robust cellular bioenergetics is vital in the energy-demanding process of maintaining matrix homeostasis in the intervertebral disc. Age-related decline in disc cellular bioenergetics is hypothesised to contribute to the matrix homeostatic perturbati
Externí odkaz: https://doaj.org/article/adc6cc00a1a546b9bd9287de1fc808ac
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2
Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws
Autor: Jd, Whalen, El, Lechman, Ca, Carlos, Weiss K, Imre Kovesdi, Jc, Glorioso, Pd, Robbins, Ch, Evans
Publikováno v: Europe PubMed Central
Gene therapy is a promising new approach in the treatment of rheumatoid arthritis. Gene delivery to diseased joints offers the prospect of achieving high, local concentrations of a therapeutic gene product in a sustained manner, while minimizing expo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fbfbdba8e0cf82554addf6fe1b3ca388
https://pubmed.ncbi.nlm.nih.gov/10092823
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3
Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells
Autor: Couderc B, laurence ZITVOGEL, Douin-Echinard V, Djennane L, Tahara H, Favre G, Mt, Lotze, Pd, Robbins
Publikováno v: ResearcherID
Europe PubMed Central
CD70 (CD27 ligand (CD27L)), CD153 (CD30L), and CD154 (CD40L) are members of the tumor necrosis factor family of costimulatory molecules and expressed on the surface of T cells that are important for both T- and B-cell help. We examined the capacity f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f8e67c57ef50c1977db807ae08b266fa
https://pubmed.ncbi.nlm.nih.gov/9622100
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6
Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees
Autor: Er, Lechman, Jaffurs D, Sc, Ghivizzani, Gambotto A, Imre Kovesdi, Mi Z, Ch, Evans, Pd, Robbins
Publikováno v: Scopus-Elsevier
Europe PubMed Central
IL-10, a cytokine produced primarily by macrophages, B lymphocytes, and Th2 cells, has both immunostimulatory and immunosuppressive properties. A homologue of IL-10 encoded by EBV, known as viral IL-10 (vIL-10), is also able to suppress the immune re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8f76eece950d86e9801decc35f31986d
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033566812&partnerID=MN8TOARS
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7
Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector
Autor: Tahara H, laurence ZITVOGEL, Wj, Storkus, Hj, Zeh, Tg, Mckinney, Rd, Schreiber, Gubler U, Pd, Robbins, Mt, Lotze
Publikováno v: Europe PubMed Central
Our recent studies using IL-12 protein or fibroblasts genetically engineered to secrete IL-12 have demonstrated profound antitumor effects of IL-12 in murine models. The antitumor effects of local, high level IL-12 expression were examined using a re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b01143ef9e9e588d1d810bbae2529d61
http://europepmc.org/abstract/med/7759882
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8
Exosomes in the Pathogenesis, Diagnosis and Treatment of Pancreatic Diseases
Autor: Marta Garcia-Contreras, Ricordi C, Pd, Robbins, Oltra E
Publikováno v: Marta Garcia-Contreras
CellR4 Repair Replace Regen Reprogram
Exosomes (EXOs) are small vesicles (30-200 nm) of endocytic origin, which are released by many different cell types into the extracellular space. They may play a key role in facilitating cell-cell communication, under both physiological and pathologi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0690584522289967d7a4bd2334f56239
https://europepmc.org/articles/PMC8048207
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9
Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts
Autor: laurence ZITVOGEL, Tahara H, Pd, Robbins, Wj, Storkus, Clarke MR, Ma, Nalesnik, Mt, Lotze
Publikováno v: Europe PubMed Central
IL-12 is a heterodimeric cytokine produced by macrophages, mitogen stimulated- or EBV infected-B lymphocytes, keratinocytes, and probably dendritic cells, with important immunoregulatory functions in vitro and in vivo. It directly stimulates activate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::54d4f58410a7b436e3da4a8d6ddfcfd2
http://europepmc.org/abstract/med/7636204
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10
Akademický článek
The 2024 OREF Clinical Research Award: Progress Toward a Gene Therapy for Arthritis.
Autor: Evans CH; From the Departments of Physical Medicine & Rehabilitation, Orthopedic Surgery and Molecular Medicine, Mayo Clinic, Rochester, NY (Evans), the Department of Orthopedics and Rehabilitation, University of Florida College of Medicine, Gainesville, FL (Ghivizzani), and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota School of Medicine, Minneapolis, MN (Robbins)., Ghivizzani SC, Robbins PD
Publikováno v: The Journal of the American Academy of Orthopaedic Surgeons [J Am Acad Orthop Surg] 2024 Dec 01; Vol. 32 (23), pp. 1052-1060. Date of Electronic Publication: 2024 Oct 17.
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