Zobrazeno 1 - 10 of 327 pro vyhledávání: '"Pc, Heinrich"'
1
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130
Autor: Hm, Hermanns, Radtke S, Haan C, Schmitz-Van de Leur H, Tavernier J, Pc, Heinrich, Iris Behrmann
Publikováno v: Europe PubMed Central
Leukemia inhibitory factor (LIF), cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M (OSM) lead to heterodimerization of LIF receptor (LIFR) or the OSM-specific receptor (OSMR) with glycoprotein (gp) 130, the common receptor subunit for I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bc6019666efa2f2fdc7fd0c1a4aba634
https://pubmed.ncbi.nlm.nih.gov/10586060
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2
Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins
Autor: Mackiewicz A, Schooltink H, Pc, Heinrich, Stefan Rose-John
Publikováno v: Europe PubMed Central
IL-6 is a major regulator of acute phase protein synthesis in the liver. It exerts its action via a plasma membrane receptor consisting of two subunits, a ligand binding 80-kDa glycoprotein and a 130-kDa glycoprotein involved in signal transduction.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de455b35c5aab9d52c56175ab498eac3
https://pubmed.ncbi.nlm.nih.gov/1381393
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4
Development of a human interleukin-6 receptor antagonist
Autor: Jp, Brakenhoff, Fd, Hon, Véronique Fontaine, ten Boekel E, Schooltink H, Rose-John S, Pc, Heinrich, Content J, La, Aarden
Publikováno v: Europe PubMed Central
Neutralizing monoclonal antibodies specific for human interleukin-6 (IL-6) bind two distinct sites on the IL-6 protein (sites I and II). Their interference with IL-6 receptor binding suggested that site I is a receptor-binding site of IL-6, whereas s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::18ae1b86491c67e2a7ea66500dc384df
http://europepmc.org/abstract/med/8276883
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5
Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding
Autor: van Dam M, Müllberg J, Schooltink H, Stoyan T, Jp, Brakenhoff, Graeve L, Pc, Heinrich, Stefan Rose-John
Publikováno v: Europe PubMed Central
As an approach to understanding the interaction of interleukin-6 (IL-6) and its 80-kDa receptor (gp80), we have constructed chimeric human/murine IL-6-molecules, which were expressed in Escherichia coli and analyzed for biological activity and recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2c64f68de83c6fa97bcf70d2f3fe2c67
http://europepmc.org/abstract/med/8325898
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7
The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site
Autor: Müllberg J, Oberthür W, Lottspeich F, Mehl E, Dittrich E, Graeve L, Pc, Heinrich, Stefan Rose-John
Publikováno v: Europe PubMed Central
Like many proteins with a single transmembrane domain the IL-6R exists in a membrane-associated and soluble form. The soluble IL-6R is generated by limited proteolysis of the membranous receptor. This process, also called shedding, is drastically enh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcfede1cdcf1ff69be44488d3fcbe0c
http://europepmc.org/abstract/med/8176214
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8
Akademický článek
Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling.
Autor: Bode JG; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Medical Faculty, Heinrich-Heine University, Moorenstraße 5, D-40225 Düsseldorf, Germany. Johannes.Bode@med.uni-duesseldorf.de, Albrecht U, Häussinger D, Heinrich PC, Schaper F
Publikováno v: European journal of cell biology [Eur J Cell Biol] 2012 Jun-Jul; Vol. 91 (6-7), pp. 496-505. Date of Electronic Publication: 2011 Nov 16.
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9
Akademický článek
Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.
Autor: Radtke S; Department of Biochemistry and Molecular Biology, Medical School RWTH Aachen, 52074 Aachen, Germany., Wüller S, Yang XP, Lippok BE, Mütze B, Mais C, de Leur HS, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM
Publikováno v: Journal of cell science [J Cell Sci] 2010 Mar 15; Vol. 123 (Pt 6), pp. 947-59.
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10
Akademický článek
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Autor: Bender H; Department of Biochemistry, University Hospital RWTH-Aachen, Aachen, Germany., Wiesinger MY, Nordhoff C, Schoenherr C, Haan C, Ludwig S, Weiskirchen R, Kato N, Heinrich PC, Haan S
Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2009 Aug; Vol. 50 (2), pp. 585-91.
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