Hepatopulmonary Syndrome, Another Face of Dysregulated BMP9 Signaling.

Autor: Sangam S; Massachusetts General Hospital Harvard Medical School Boston, Massachusetts., Yu PB; Massachusetts General Hospital Harvard Medical School Boston, Massachusetts.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Sep 01; Vol. 210 (5), pp. 543-544.

FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report.

Autor: Tzani A; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Haemmig S; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Cheng HS; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Pérez-Cremades D; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Heuschkel MA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Jamaiyar A; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Singh SA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Aikawa M; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Yu PB; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Wang T; Department of Ophthalmology, Boston Children's Hospital, MA (T.W., Y.S.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Sun Y; Department of Ophthalmology, Boston Children's Hospital, MA (T.W., Y.S.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Feinberg MW; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.)., Plutzky J; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., M.W.F., J.P.).; Harvard Medical School, Boston, MA (A.T., S.H., H.S.C., D.P.-C., M.A.H., A.J., S.A.S., M.A., P.B.Y., T.W., Y.S., M.W.F., J.P.).

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2024 Jan; Vol. 44 (1), pp. 143-155. Date of Electronic Publication: 2023 Nov 09.

Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension.

Autor: Zhong Y; Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston., Yu PB; Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2023 Oct; Vol. 43 (10), pp. 1784-1787. Date of Electronic Publication: 2023 Sep 07.

Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis.

Autor: Meng Z; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Zhang S; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA.; Hainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research & Key Laboratory of Emergency and Trauma of Ministry of Education, Institute of Cardiovascular Research of the First Affiliated Hospital, Hainan Medical University, Haikou 571199, Hainan, China., Li W; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, Jilin, China., Wang Y; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA.; Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Wang M; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Liu X; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Liu CL; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA.; Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Liao S; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Liu T; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Yang C; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA.; Department of Geriatrics, National Key Clinical Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510000, Guangdong, China., Lindholt JS; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark.; Elite Research Centre of Individualized Treatment for Arterial Disease, University Hospital, Odense, Denmark., Rasmussen LM; Elite Research Centre of Individualized Treatment for Arterial Disease, University Hospital, Odense, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark., Obel LM; Elite Research Centre of Individualized Treatment for Arterial Disease, University Hospital, Odense, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark., Stubbe J; Cardiovascular and Renal Research unit, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark., Diederichsen AC; Elite Research Centre of Individualized Treatment for Arterial Disease, University Hospital, Odense, Denmark.; Department of Cardiology, Odense University Hospital, Odense, Denmark., Sun Y; Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Birmingham VA Medical Center, Research Department, Birmingham, AL 35294, USA., Chen Y; Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Birmingham VA Medical Center, Research Department, Birmingham, AL 35294, USA., Yu PB; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Libby P; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Shi GP; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA., Guo J; Hainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research & Key Laboratory of Emergency and Trauma of Ministry of Education, Institute of Cardiovascular Research of the First Affiliated Hospital, Hainan Medical University, Haikou 571199, Hainan, China.

Publikováno v: European heart journal [Eur Heart J] 2023 Aug 01; Vol. 44 (29), pp. 2763-2783.

Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.

Autor: Chakraborty A; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA.; These authors contributed equally., Nathan A; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA.; These authors contributed equally., Orcholski M; Department of Medicine, University of Laval, Quebec City, QC, Canada., Agarwal S; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Shamskhou EA; University of Washington, Seattle, WA, USA., Auer N; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Mitra A; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Guardado ES; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Swaminathan G; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Condon DF; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Yu J; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., McCarra M; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Juul NH; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Mallory A; University of Colorado, Boulder, CO, USA., Guzman-Hernandez RA; University of Puerto Rico Medical School, San Juan, PR, USA., Yuan K; Boston Children's Hospital, Boston, MA, USA., Rojas V; University of Nevada, Las Vegas, NV, USA., Crossno JT; Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Yung LM; Brigham and Women's Hospital, Boston, MA, USA., Yu PB; Brigham and Women's Hospital, Boston, MA, USA., Spencer T; Washington State University, Pullman, WA, USA., Winn RA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Frump A; Indiana University, Indianapolis, IN, USA., Karoor V; National Jewish Center, Denver, CO, USA., Lahm T; National Jewish Center, Denver, CO, USA., Hedlin H; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA., Fineman JR; Department of Pediatrics and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA., Lafyatis R; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Knutsen CNF; Division of Pediatric Critical Care Medicine, Stanford University, Palo Alto, CA, USA., Alvira CM; Division of Pediatric Critical Care Medicine, Stanford University, Palo Alto, CA, USA., Cornfield DN; Division of Pediatric Pulmonary and Critical Care Medicine, Stanford University, Palo Alto, CA, USA., de Jesus Perez VA; Division of Pulmonary and Critical Care, Stanford University, Palo Alto, CA, USA vdejesus@stanford.edu.

Publikováno v: The European respiratory journal [Eur Respir J] 2023 Jun 08; Vol. 61 (6). Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023).