Protective effect of the type IV phosphodiesterase inhibitor rolipram in EAU: protection is independent of IL-10-inducing activity

Autor: Xu H, Strassmann G, Cc, Chan, Lv, Rizzo, Pb, Silver, Wiggert B, Rachel Caspi

Publikováno v: Europe PubMed Central

Experimental autoimmune uveoretinitis (EAU) is a cell-mediated model of retinal autoimmunity that is negatively regulated by interleukin (IL)-10. The antidepressant drug rolipram, a type IV phosphodiesterase inhibitor, enhances IL-10 production by mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::05cc379845d5f1d366a4730cf6644d62
https://pubmed.ncbi.nlm.nih.gov/10102291

Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype

Autor: Pb, Silver, Lv, Rizzo, Cc, Chan, La, Donoso, Wiggert B, Rachel Caspi

Publikováno v: Europe PubMed Central

Mice of the H-2b, H-2k, and H-2r haplotypes develop experimental autoimmune uveoretinitis (EAU) after immunization with interphotoreceptor retinoid-binding protein (IRBP) of bovine or monkey origin. The purpose of this study was to identify putative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2045035033af1015c99bfbcf1703a887
https://pubmed.ncbi.nlm.nih.gov/7706044

Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis

Autor: Pb, Silver, Tk, Tarrant, Cc, Chan, Wiggert B, Rachel Caspi

Publikováno v: Europe PubMed Central

Nitric oxide (NO) is an important mediator of inflammatory tissue damage. The present study addresses the question whether inducible nitric oxide synthase (iNOS), and consequently the ability to upregulate NO, is required to effect the pathogenesis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9a86e364716b8918dd08f9e0cafed758
http://europepmc.org/abstract/med/10235566

Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis

Autor: Tk, Tarrant, Pb, Silver, Cc, Chan, Wiggert B, Rachel Caspi

Publikováno v: Europe PubMed Central

Experimental autoimmune uveitis (EAU) has been associated with a Th1 response. However, in IFN-gamma-deficient mice, EAU develops in the context of an effector response having Th2-like elements, and administration of IL-12 to mice immunized for EAU i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::26f4ff099a8b3c56464bba3a9c026c1c
http://europepmc.org/abstract/med/9647215

Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation.

Autor: Bing SJ; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Silver PB; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Jittayasothorn Y; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Mattapallil MJ; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Chan CC; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Horai R; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: hreiko@mail.nih.gov., Caspi RR; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: caspir@mail.nih.gov.

Publikováno v: Journal of autoimmunity [J Autoimmun] 2020 Nov; Vol. 114, pp. 102507. Date of Electronic Publication: 2020 Jun 24.