Zobrazeno 1 - 10 of 270 pro vyhledávání: '"Pb, Mccray"'
2
Development of retroviral vectors for gene transfer to airway epithelia
Autor: Wang G, Patrick Sinn, Pb, Mccray
Publikováno v: Europe PubMed Central
Scopus-Elsevier
Retroviral vectors offer several potential advantages for attaining persistent expression of a therapeutic gene in airway epithelia for diseases such as cystic fibrosis. However, several problems have limited their application. Developments in vector
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1dcf313f972d253dc4280d429081ff19
http://europepmc.org/abstract/med/11249752
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3
Akademický článek
Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells.
Autor: Kulhankova K; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Cheng AX; Feldan Therapeutics, Quebec, Qc, Canada., Traore S; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Auger M; Feldan Therapeutics, Quebec, Qc, Canada.; Department of Chemical Engineering, Laval University, Quebec, Qc, Canada., Pelletier M; Feldan Therapeutics, Quebec, Qc, Canada.; Department of Chemical Engineering, Laval University, Quebec, Qc, Canada., Hervault M; Feldan Therapeutics, Quebec, Qc, Canada., Wells KD; Division of Animal Sciences, Swine Somatic Cell Genome Editing Center, University of Missouri, Columbia, MO, USA., Green JA; Division of Animal Sciences, Swine Somatic Cell Genome Editing Center, University of Missouri, Columbia, MO, USA., Byrne A; Division of Animal Sciences, Swine Somatic Cell Genome Editing Center, University of Missouri, Columbia, MO, USA., Nelson B; Division of Animal Sciences, Swine Somatic Cell Genome Editing Center, University of Missouri, Columbia, MO, USA., Sponchiado M; Division of Animal Sciences, Swine Somatic Cell Genome Editing Center, University of Missouri, Columbia, MO, USA., Boosani C; Division of Animal Sciences, Swine Somatic Cell Genome Editing Center, University of Missouri, Columbia, MO, USA., Heffner CS; The Jackson Laboratory, Genetic Resource Science, Bar Harbor, ME, USA., Snow KJ; The Jackson Laboratory, Genetic Resource Science, Bar Harbor, ME, USA., Murray SA; The Jackson Laboratory, Genetic Resource Science, Bar Harbor, ME, USA., Villacreses RA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Rector MV; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, USA., Gansemer ND; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, USA., Stoltz DA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, USA.; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Allamargot C; Central Microscopy Research Facility (CMRF), and Office for the Vice President of Research (OVPR), University of Iowa, Iowa City, IA, USA., Couture F; TransBIOTech, Lévis, Qc, Canada., Hemez C; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Hallée S; Feldan Therapeutics, Quebec, Qc, Canada., Barbeau X; Feldan Therapeutics, Quebec, Qc, Canada., Harvey M; Feldan Therapeutics, Quebec, Qc, Canada., Lauvaux C; Feldan Therapeutics, Quebec, Qc, Canada., Gaillet B; Department of Chemical Engineering, Laval University, Quebec, Qc, Canada., Newby GA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., McCray PB Jr; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Guay D; Feldan Therapeutics, Quebec, Qc, Canada.; Department of Chemical Engineering, Laval University, Quebec, Qc, Canada.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Oct 28; Vol. 52 (19), pp. 11911-11925.
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4
Akademický článek
IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption.
Autor: Romano Ibarra GS; Department of Internal Medicine., Lei L; Department of Pediatrics., Yu W; Department of Internal Medicine., Thurman AL; Department of Internal Medicine., Gansemer ND; Department of Internal Medicine., Meyerholz DK; Department of Pathology., Pezzulo AA; Department of Internal Medicine.; Pappajohn Biomedical Institute, and., McCray PB; Department of Internal Medicine.; Department of Pediatrics.; Pappajohn Biomedical Institute, and., Thornell IM; Department of Internal Medicine.; Pappajohn Biomedical Institute, and., Stoltz DA; Department of Internal Medicine.; Pappajohn Biomedical Institute, and.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA.
Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Sep 10; Vol. 134 (21). Date of Electronic Publication: 2024 Sep 10.
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5
Akademický článek
High ionic strength vector formulations enhance gene transfer to airway epithelia.
Autor: Cooney AL; University of Iowa, Stead Family Department of Pediatrics; Iowa City, IA 52242, USA.; University of Iowa, Pappajohn Biomedical Institute; Iowa City, IA 52242, USA., Loza LM; University of Iowa, Stead Family Department of Pediatrics; Iowa City, IA 52242, USA.; University of Iowa, Pappajohn Biomedical Institute; Iowa City, IA 52242, USA., Najdawi K; University of Iowa, Stead Family Department of Pediatrics; Iowa City, IA 52242, USA.; University of Iowa, Pappajohn Biomedical Institute; Iowa City, IA 52242, USA., Brommel CM; University of Iowa, Stead Family Department of Pediatrics; Iowa City, IA 52242, USA.; University of Iowa, Pappajohn Biomedical Institute; Iowa City, IA 52242, USA., McCray PB Jr; University of Iowa, Stead Family Department of Pediatrics; Iowa City, IA 52242, USA.; University of Iowa, Pappajohn Biomedical Institute; Iowa City, IA 52242, USA.; University of Iowa, Center for Gene Therapy; Iowa City, IA 52242, USA., Sinn PL; University of Iowa, Stead Family Department of Pediatrics; Iowa City, IA 52242, USA.; University of Iowa, Pappajohn Biomedical Institute; Iowa City, IA 52242, USA.; University of Iowa, Center for Gene Therapy; Iowa City, IA 52242, USA.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Sep 09; Vol. 52 (16), pp. 9369-9383.
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6
Akademický článek
Development and Initial Characterization of Pigs with DNAI1 Mutations and Primary Ciliary Dyskinesia.
Autor: Abou Alaiwa MA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242., Hilkin BM; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Price MP; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Gansemer ND; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Rector MR; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Stroik MR; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Powers LS; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Whitworth KM; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Samuel MS; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Jain A; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Ostedgaard LS; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Ernst SE; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Philibert W; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242., Boyken LD; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Moninger TO; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Karp PH; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Hornick DB; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Sinn PL; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Fischer AJ; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Pezzulo AA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., McCray PB Jr; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Meyerholz DK; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Zabner J; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Prather RS; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Welsh MJ; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242., Stoltz DA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242.
Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 21. Date of Electronic Publication: 2024 Aug 21.
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7
Akademický článek
Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells.
Autor: Sousa AA; Merkin Institute of Transformative Technologies in Healthcare, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Hemez C; Merkin Institute of Transformative Technologies in Healthcare, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Lei L; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Traore S; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Kulhankova K; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Newby GA; Merkin Institute of Transformative Technologies in Healthcare, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Doman JL; Merkin Institute of Transformative Technologies in Healthcare, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Oye K; Merkin Institute of Transformative Technologies in Healthcare, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Pandey S; Merkin Institute of Transformative Technologies in Healthcare, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Karp PH; Department of Internal Medicine and Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, IA, USA., McCray PB Jr; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. drliu@fas.harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.
Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 Jul 10. Date of Electronic Publication: 2024 Jul 10.
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8
Akademický článek
IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo.
Autor: Ghimire S; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Xue B; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Li K; Stead Family Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA., Gannon RM; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Wohlford-Lenane CL; Stead Family Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA., Thurman AL; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Gong H; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Necker GC; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Zheng J; Department of Microbiology and Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Meyerholz DK; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Perlman S; Stead Family Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.; Department of Microbiology and Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., McCray PB Jr; Stead Family Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.; Department of Microbiology and Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa., Pezzulo AA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 04. Date of Electronic Publication: 2024 Jul 04.
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9
Akademický článek
Dynamic measurement of airway surface liquid volume with an ex vivo trachea-chip.
Autor: Scott M; Roy J. Carver Department of Biomedical Engineering, University of Iowa, USA. yuliang-xie@uiowa.edu., Lei L; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, USA., Bierstedt KC; Roy J. Carver Department of Biomedical Engineering, University of Iowa, USA. yuliang-xie@uiowa.edu., McCray PB Jr; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, USA., Xie Y; Roy J. Carver Department of Biomedical Engineering, University of Iowa, USA. yuliang-xie@uiowa.edu.
Publikováno v: Lab on a chip [Lab Chip] 2024 Jun 11; Vol. 24 (12), pp. 3093-3100. Date of Electronic Publication: 2024 Jun 11.
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10
Akademický článek
A predominately pulmonary activation of complement in a mouse model of severe COVID-19.
Autor: Szachowicz PJ; Department of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242., Wohlford-Lenane C; Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242., Heinen CJ; Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, USA., Ghimire S; Department of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242., Xue B; Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242., Boly TJ; Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242., Verma A; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, 52242., MašinoviĆ L; Department of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242., Bermick JR; Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242., Perlman S; Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, 52242., Meyerholz DK; Department of Pathology, The University of Iowa, Iowa City, IA, 52242., Pezzulo AA; Department of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242., Zhang Y; Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, USA., Smith RJH; Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, USA., McCray PB Jr; Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.; Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, 52242.
Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 03. Date of Electronic Publication: 2024 Jun 03.
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