Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

Autor: Ackerley, Cassie Grimsley, Graciaa, Daniel, Kelley, Colleen, Rouphael, Nadine, Curate-Ingram, Sharon, Korber, Bette, Wagh, Kshitij, Sane, Nandini, Grossman, Jennifer, Hasan, Sophie, Robinson, Michelle, Lucas, Jonathan, Gildea, Marianne, Babinec, Amber, Coomes, Bethany, Dumond, Julie, Beck, Justine, Chege, Wairimu, Han, Xue, Hanke, Jen, Karg, Carissa, Rinn, Laurie, Chicurel-Bayard, Miriam, Nagar, Shashikala, White, Hakeem, Cooley, W Scott, Broder, Gail, Hunt, Machel, Cummings, Vanessa, Donaty, Kristine, Randhawa, April, Fair, Ramey, Darden-Tabb, Noshima, Chaturvedi, Richa, Baden, Lindsey, Sherman, Amy, Gothing, Jon, Paz, Andres Avila, Klopfer, Julia, Powell, Megan, Piermattei, Anna, Heithoff, August, Weiner, Joshua A., Kovacikova, Gabriela, Axelrod, Katherine S., Zhang, Lu, Baral, Saman, Yates, Nicole, Chiong, Kelvin, Kuo, Irene, Jordan, Jeanne, Lintner, Madison, Langlands, Kayley, Saintilma, Bitana, Yellin, Hannah, Balachandran, Madhu, Magnus, Manya, Baumblatt, Jane, Tindale, India, Fortier, Samantha, Khodabakhshian, Aleen, Pierce, Nick, Gonzalez, Maricela, Mark, Lisa, Kuo, Melinda, Afemata, Ste'von, Edupuganti, Srilatha ^{a, *, *}, Hurt, Christopher B ^{b, *}, Stephenson, Kathryn E ^{c, *}, Huang, Yunda ^{d, e}, Paez, Carmen A ^d, Yu, Chenchen ^d, Yen, Catherine ^f, Hanscom, Brett ^d, He, Zonglin ^d, Miner, Maurine D ^d, Gamble, Theresa ^g, Heptinstall, Jack ^h, Seaton, Kelly E ^h, Domin, Elizabeth ^h, Lin, Bob C ^f, McKee, Krisha ^f, Doria-Rose, Nicole ^f, Regenold, Stephanie ^f, Spiegel, Hans ^p, Anderson, Maija ^d, McClosky, Nadia ^d, Zhang, Lily ^d, Piwowar-Manning, Estelle ⁱ, Ackerman, Margaret E ^j, Pensiero, Michael ^f, Dye, Bonnie J ^g, Landovitz, Raphael J ^k, Mayer, Kenneth ^l, Siegel, Marc ⁿ, Sobieszczyk, Magdalena ^o, Walsh, Stephen R ^m, Gama, Lucio ^f, Barouch, Dan H ^c, Montefiori, David C ^h, Tomaras, Georgia D ^h

Publikováno v: In The Lancet HIV January 2025 12(1):e13-e25