Influence of Genetic Variations on Levels of Inflammatory Markers of Healthy Subjects at Baseline and One Week after Clopidogrel Therapy; Results of a Preliminary Study

Autor: Sophie Visvikis-Siest, Pascale Gaussem, Sébastien Bertil, Jean-Sébastien Hulot, Daniel Lambert, Christine Masson, Payman Shahabi, Gérard Siest, Bernard Herbeth

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 16402-16413 (2013)

We aimed to assess the association between the most common polymorphisms of cytochrome P450 (CYP) epoxygenases on the plasma levels of inflammatory markers in a population of healthy subjects. We also sought to determine whether CYP2C19*2 polymorphis

Externí odkaz: https://doaj.org/article/7676460c879f4cd3b23c41f798cf9c6d

Obesity status modifies the association between rs7556897T>C in the intergenic region SLC19A3-CCL20 and blood pressure in French children

Autor: Maria G. Stathopoulou, George V. Dedoussis, Pia Chedid, Philippe Froguel, Sophie Visvikis-Siest, Said El Shamieh, Ndeye Coumba Ndiaye, Ali Salami, Payman Shahabi, Amélie Bonnefond, Cécile Lecoeur, Sébastien Dadé, David Meyre

Publikováno v: Clinical Chemistry and Laboratory Medicine
Clinical Chemistry and Laboratory Medicine, De Gruyter, 2020, 58 (11), pp.1819-1827. ⟨10.1515/cclm-2019-0292⟩
Clinical Chemistry and Laboratory Medicine, 2020, 58 (11), pp.1819-1827. ⟨10.1515/cclm-2019-0292⟩

Background Growing evidence reports an association between inflammatory markers, obesity and blood pressure (BP). Specifically, the intergenic single nucleotide polymorphism (SNP) rs7556897T > C (MAF = 0.34) located between SLC19A3 and the CCL20 was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a7e7ac57cb1ec5abb981e2ca54ff65
https://hal.univ-lorraine.fr/hal-03081429

An expanded pharmacogenomics warfarin dosing table with utility in generalised dosing guidance

Autor: Michael F. Christman, Sylvie Perreault, Marie-Pierre Dubé, Lisa Wawak, Joseph P. Jarvis, Rachel S. Kasper, Erynn S. Gordon, Payman Shahabi, Neda Gharani, Daniel E. Lynch, Laura B. Scheinfeldt, Tara J. Schmidlen, Norman P. Gerry, Margaret A. Keller

Publikováno v: Thrombosis and Haemostasis. 116:337-348

SummaryPharmacogenomics (PGx) guided warfarin dosing, using a comprehensive dosing algorithm, is expected to improve dose optimisation and lower the risk of adverse drug reactions. As a complementary tool, a simple genotype-dosing table, such as in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf4f3af02e0ca02ca1ea759c392d0c9
https://doi.org/10.1160/th15-12-0955

Cardiovascular pharmacogenomics; state of current knowledge and implementation in practice

Autor: Payman Shahabi, Marie-Pierre Dubé

Publikováno v: International Journal of Cardiology. 184:772-795

Pharmacogenomics (PGx) is the science that examines how an individual's genetic make-up affects the safety and efficacy of therapeutic drugs. PGx of response to cardiovascular (CV) medications is of the most successfully translated branches of PGx in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c429b89f9ef43cffcee1c8888b29f3
https://doi.org/10.1016/j.ijcard.2015.02.025

Conference Scene: Systems biology and personalized health science and translation

Autor: Gérard Siest, Thibaut Godjo, Abdel Salam Saleh, Ndeye Coumba Ndiaye, Laetitia Albertini, Payman Shahabi, Said El Shamieh, Sophie Visvikis-Siest, Maria G. Stathopoulou

Publikováno v: Pharmacogenomics. 14:1953-1964

After a 1-day advanced course on systems biology, the main themes of this 3-day colloquium were developed: from systems biology to systems medicine with special applications to cancer; pharmacogenomics in drug discovery and clinical application; and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2c4d52999e730f9fd351cdb3f466075
https://doi.org/10.2217/pgs.13.201