β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells

Autor: Payman Hojabrpour, Robert G. McCormack, Vincent Duronio, Felipe Eltit, Rouhollah Mousavizadeh, Shoukat Dedhar, Seyed Mehdi Jafarnejad, Alex Scott, Paul C. McDonald

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Mousavizadeh, R, Hojabrpour, P, Eltit, F, McDonald, P C, Dedhar, S, McCormack, R G, Duronio, V, Jafarnejad, S M & Scott, A 2020, ' β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells ', Scientific Reports, vol. 10, no. 1, pp. 12644 . https://doi.org/10.1038/s41598-020-69267-6
Scientific Reports

Tendons are specialized tissues composed primarily of load-responsive fibroblasts (tenocytes) embedded in a collagen-rich extracellular matrix. Habitual mechanical loading or targeted exercise causes tendon cells to increase the stiffness of the extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4f0211504058a8a33521d0f3c3cfa2
http://link.springer.com/article/10.1038/s41598-020-69267-6

The small molecule 2-phenylethynesulfonamide induces covalent modification of p53

Autor: Sarwat Jamil, Payman Hojabrpour, Vincent Duronio

Publikováno v: Biochemical and biophysical research communications. 482(1)

p53 is a tumor suppressor protein which is either lost or inactivated in a large majority of tumors. The small molecule 2-phenylethynesulfonamide (PES) was originally identified as the inhibitor of p53 effects on the mitochondrial death pathway. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a22e0697d7a47db2c9d6e8f7b70f462
https://pubmed.ncbi.nlm.nih.gov/27833016

An Essential Role for MCL-1 in ATR-mediated CHK1 Phosphorylation

Autor: Stefanie Cheah, Payman Hojabrpour, Shadi MojtabaviS. Mojtabavi, Vincent Duronio, Sarwat Jamil

Publikováno v: Molecular Biology of the Cell. 19:3212-3220

Here we report a novel role for myeloid cell leukemia 1 (Mcl-1), a Bcl-2 family member, in regulating phosphorylation and activation of DNA damage checkpoint kinase, Chk1. Increased expression of nuclear Mcl-1 and/or a previously reported short nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6f4e65cf86fcb3b9b21997f038920a
https://doi.org/10.1091/mbc.e07-11-1171

Identification of a Novel Phosphorylation Site, Ser-170, as a Regulator of Bad Pro-apoptotic Activity

Autor: Ruedi Aebersold, Michael P. Scheid, Vincent Duronio, Xianming Chen, Kathryn M. Schubert, Arpita Maiti, Shaynoor Dramsi, David R. Goodlett, Payman Hojabrpour

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2002, 277 (8), pp.6399-6405. ⟨10.1074/jbc.M109990200⟩

International audience; Bad is a pro-apoptotic member of the Bcl-2 family of proteins that is thought to exert a death-promoting effect by heterodimerization with Bcl-X(L), nullifying its anti-apoptotic activity. Growth factors may promote cell survi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb32b20fb401bc0c65ad4afa93e96480
https://doi.org/10.1074/jbc.m109990200

A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1

Autor: Vincent Duronio, Meera Raj, Sarwat Jamil, Payman Hojabrpour, Juergen Kast, Rafat Sobouti

Publikováno v: The Biochemical journal. 387(Pt 3)

Mcl-1 (myeloid cell leukaemia-1) is a Bcl-2 family member with short-term pro-survival functions but whose other functions, demonstrated by embryonic lethality of knockout mice, do not involve apoptosis. In the present study, we show a cell-cycle-reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9a9aa3ef4e4fea3671a514e6aaffd4
https://pubmed.ncbi.nlm.nih.gov/15554878