Zobrazeno 1 - 10 of 2 344 pro vyhledávání: '"Payan DG"'
1
Akademický článek
Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators.
Autor: Shaw SJ; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Goff DA; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Boralsky LA; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Singh R; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Sweeny DJ; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Park G; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Sun TQ; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Jenkins Y; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Markovtsov V; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Issakani SD; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Payan DG; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States., Hitoshi Y; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Dec 28; Vol. 66 (24), pp. 17086-17104. Date of Electronic Publication: 2023 Dec 11.
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2
Akademický článek
Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the Discovery of R507 as a Clinical Candidate.
Autor: Chen Y; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Li H; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Yen R; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Heckrodt TJ; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., McMurtrie D; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Singh R; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Taylor V; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Masuda ES; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Park G; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States., Payan DG; Rigel Pharmaceuticals Inc., South San Francisco, California 94080, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Oct 25; Vol. 13 (11), pp. 1805-1811. Date of Electronic Publication: 2022 Oct 25 (Print Publication: 2022).
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3
Akademický článek
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.
Autor: Shaw SJ; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States. Electronic address: sshaw@rigel.com., Goff DA; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Carroll DC; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Singh R; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Sweeny DJ; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Park G; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Jenkins Y; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Markovtsov V; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Sun TQ; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Issakani SD; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Hitoshi Y; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Payan DG; Rigel Pharmaceuticals, Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States.
Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Oct 01; Vol. 71, pp. 116951. Date of Electronic Publication: 2022 Aug 01.
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4
Akademický článek
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.
Autor: Chen Y; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States. Electronic address: ychen@rigel.com., Tso K; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Heckrodt TJ; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Li H; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Yen R; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Lin N; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Singh R; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Taylor V; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Masuda ES; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Park G; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States., Payan DG; Rigel Pharmaceuticals Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, United States.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Oct 01; Vol. 73, pp. 128900. Date of Electronic Publication: 2022 Jul 18.
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5
Akademický článek
Discovery of 5-Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors.
Autor: Chen Y; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Singh R; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Lin N; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Taylor V; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Masuda ES; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States., Payan DG; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, California 94080, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Apr 04; Vol. 13 (4), pp. 714-719. Date of Electronic Publication: 2022 Apr 04 (Print Publication: 2022).
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6
Akademický článek
From CFTR to a CF signalling network: a systems biology approach to study Cystic Fibrosis.
Autor: Najm, Matthieu1,2,3 (AUTHOR) matthieu.najm@minesparis.psl.eu, Martignetti, Loredana1,2,3 (AUTHOR), Cornet, Matthieu1,2,3,4 (AUTHOR), Kelly-Aubert, Mairead4,5 (AUTHOR), Sermet, Isabelle4,5,6 (AUTHOR), Calzone, Laurence1,2,3 (AUTHOR) laurence.calzone@curie.fr, Stoven, Véronique1,2,3 (AUTHOR) veronique.stoven@minesparis.psl.eu
Publikováno v: BMC Genomics. 9/28/2024, Vol. 25 Issue 1, p1-22. 22p.
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7
Akademický článek
Roles of post-translational modifications of UHRF1 in cancer.
Autor: Gu, Lili1,2,3 (AUTHOR), Fu, Yongming1,2,3 (AUTHOR), Li, Xiong1,2,3,4 (AUTHOR) lixiong@gdpu.edu.cn
Publikováno v: Epigenetics & Chromatin. 5/9/2024, Vol. 17 Issue 1, p1-13. 13p.
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8
Akademický článek
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.
Autor: Shaw SJ; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA. Electronic address: sshaw@rigel.com., Goff DA; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA., Lin N; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA., Singh R; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA., Li W; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA., McLaughlin J; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA., Baltgalvis KA; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA., Payan DG; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA., Kinsella TM; Rigel Pharmaceuticals, Inc., 1180, Veterans Boulevard, South San Francisco, CA 94080, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 01; Vol. 27 (11), pp. 2617-2621. Date of Electronic Publication: 2017 Mar 18.
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9
Akademický článek
Incorporation of gene ontology in identification of protein interactions from biomedical corpus: a multi-modal approach.
Autor: Jha, Kanchan1 (AUTHOR), Saha, Sriparna1 (AUTHOR), Dutta, Pratik1 (AUTHOR)
Publikováno v: Annals of Operations Research. Aug2024, Vol. 339 Issue 3, p1793-1811. 19p.
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10
Akademický článek
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