Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Payal R. Sheth"'
Autor:
Santhosh Satapati, Daniel P. Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Yingjiang Zhou, Zhao Ren, Michelle Chen, Yeon-Hee Lim, Nathan G. Hatcher, Xiujuan Wen, Payal R. Sheth, David G. McLaren, Stephen F. Previs
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 20-28 (2022)
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions. A
Externí odkaz:
https://doaj.org/article/103ba40a3e5a45859c5af8ed7bf87a21
Autor:
Paul Kirschmeier, Daniel J. Hicklin, M. Arshad Siddiqui, Payal R. Sheth, Huadong Tang, Elizabeth Smith, Bohdan Yaremko, Abdul Ponery, Lianzhu Liang, Suining Lee, Seema Tevar, Lissette Nale, Kimberly Gray, Chaoyang Dai, Ming Liu, Andrea D. Basso
Supplementary Tables 1, 2, and 3 and Supplementary Figures 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323e1342aa3b907de9717e370e74f9ef
https://doi.org/10.1158/1535-7163.22484694.v1
https://doi.org/10.1158/1535-7163.22484694.v1
Autor:
Paul Kirschmeier, Daniel J. Hicklin, M. Arshad Siddiqui, Payal R. Sheth, Huadong Tang, Elizabeth Smith, Bohdan Yaremko, Abdul Ponery, Lianzhu Liang, Suining Lee, Seema Tevar, Lissette Nale, Kimberly Gray, Chaoyang Dai, Ming Liu, Andrea D. Basso
Kinesin spindle protein (KSP) is a mitotic kinesin required for the formation of the bipolar mitotic spindle, and inhibition of this motor protein results in mitotic arrest and cell death. KSP inhibitors show preclinical antitumor activity and are cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6041f2cd41a43e8a9ab2086483f35521
https://doi.org/10.1158/1535-7163.c.6531537
https://doi.org/10.1158/1535-7163.c.6531537
Autor:
Paul A Mann, Anna Müller, Kerstin A Wolff, Thierry Fischmann, Hao Wang, Patricia Reed, Yan Hou, Wenjin Li, Christa E Müller, Jianying Xiao, Nicholas Murgolo, Xinwei Sher, Todd Mayhood, Payal R Sheth, Asra Mirza, Marc Labroli, Li Xiao, Mark McCoy, Charles J Gill, Mariana G Pinho, Tanja Schneider, Terry Roemer
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005585 (2016)
Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we demonstrate interconverts UDP-GlcNAc and UDP-ManNAc to modulate substrate levels of TarO and TarA w
Externí odkaz:
https://doaj.org/article/553e0e069b9b42ba9dcf7bc9124cd8c8
Autor:
Wendy Zhong, David G. McLaren, Daniel Metzger, Ji Zhang, Daniel P. Downes, Payal R. Sheth, Saswata Talukdar, Julie Lao, Guillermo Godinez, Santhosh Satapati, Stephen F. Previs, Bingming Chen
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:2421-2425
Spatial characterization of triglyceride metabolism is an area of significant interest which can be enabled by mass spectrometry imaging via recent advances in neutral lipid laser desorption analytical approaches. Here, we extend recent advancements
Autor:
Xiujuan Wen, Kiersten Tovar, Gregory O'Donnell, Santhosh Satapati, Chang Liu, Lucien P. Ghislain, Steven J. Stout, Steven Cifelli, Vinit Shah, Kevin P. Bateman, Payal R. Sheth, Sammy S Datwani, David G. McLaren, Mary Jo Wildey, Thomas R. Covey
Publikováno v:
Analytical chemistry. 93(15)
The primary goal of high-throughput screening (HTS) is to rapidly survey a broad collection of compounds, numbering from tens of thousands to millions of members, and identify those that modulate the activity of a therapeutic target of interest. For
Autor:
Thomas W. Rosahl, Gayathri Swaminath, Heather Zhou, Payal R. Sheth, Rugmani Padmanabhan Iyer, Nesrine El-Bizri, Jing Liu, Rachel Matt, Girija Raman, Keith Q. Tanis
Publikováno v:
Circulation. 142
Increased myocardial stiffness is a hallmark of impaired diastole in heart failure (HF). Hypo-phosphorylation of the N2B unique sequence (N2Bus) of titin (TTN), a giant myofilament protein, increases passive tension leading to diastolic dysfunction i
Autor:
Takhar Kasumov, Jennifer O'Neil, Michael J. Previs, Ying Chen, David G. McLaren, Jason E. Imbriglio, Paul Tawa, Haihong Zhou, Stephen F. Previs, Natalie A. Daurio, Payal R. Sheth, Nadia Rachdaoui
Publikováno v:
ACS chemical biology. 15(10)
The ability to target specific proteins for degradation may open a new door toward developing therapeutics. Although effort in chemistry is essential for advancing this modality, i.e., one needs to generate proteolysis targeting chimeras (bifunctiona
Autor:
Daniel P, Downes, Takhar, Kasumov, Natalie A, Daurio, Neil B, Wood, Michael J, Previs, Payal R, Sheth, David G, McLaren, Stephen F, Previs
Publikováno v:
Metabolites
Stable isotope tracers can be used to quantify the activity of metabolic pathways. Specifically, 2H-water is quite versatile, and its incorporation into various products can enable measurements of carbohydrate, lipid, protein and nucleic acid kinetic
Autor:
Adam B Weinglass, Nicholas B Hastings, Bradley S Sherborne, Jennifer M. Johnston, Andrew D Howard, Maria Webb, Steven L. Colletti, Clemens Vonrhein, Kevin J. Lumb, Srivanya Tummala, Frank K Brown, Jennifer Hadix, Hubert Josien, Stephen M. Soisson, Guo Yan, Harry R. Chobanian, John Wang, Michael W. Miller, Brande Thomas-Fowlkes, Dawn L. Hall, Jeffrey D. Hermes, Thu Ho, Barbara Pio, Payal R. Sheth, Sujata Sharma, Maria Kornienko, Samantha J Allen, Sangita B. Patel, Jerry Di Salvo, Sarah Souza, Gérard Bricogne, Christopher W Plummer, Jun Lu, Noel Byrne
Publikováno v:
Nature Structural & Molecular Biology. 24:570-577
Clinical studies indicate that partial agonists of the G-protein-coupled, free fatty acid receptor 1 GPR40 enhance glucose-dependent insulin secretion and represent a potential mechanism for the treatment of type 2 diabetes mellitus. Full allosteric